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Abstract

SARS-CoV-2 IgG screening of 1,000 antenatal serum samples in the Oxford area, United Kingdom, between 14 April and 15 June 2020, yielded a 5.3% seroprevalence, mirroring contemporaneous regional data. Among the 53 positive samples, 39 showed in vitro neutralisation activity, correlating with IgG titre (Pearson’s correlation p<0.0001). While SARS-CoV-2 seroprevalence in pregnancy cohorts could potentially inform population surveillance, clinical correlates of infection and immunity in pregnancy, and antenatal epidemiology evolution over time need further study.

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/content/10.2807/1560-7917.ES.2020.25.41.2001721
2020-10-22
2024-12-03
http://instance.metastore.ingenta.com/content/10.2807/1560-7917.ES.2020.25.41.2001721
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SARS-CoV-2 antibody prevalence, titres and neutralising activity in an antenatal cohort, United Kingdom, 14 April to 15 June 2020
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=Sheila+F+Lumley&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Lumley Sheila F</a>, <a href="/search?value1=David+W+Eyre&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Eyre David W</a>, <a href="/search?value1=Anna+L+McNaughton&option1=author&noRedirect=true" class="nonDisambigAuthorLink">McNaughton Anna L</a>, <a href="/search?value1=Alison+Howarth&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Howarth Alison</a>, <a href="/search?value1=Sarah+Hoosdally&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Hoosdally Sarah</a>, <a href="/search?value1=Stephanie+B+Hatch&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Hatch Stephanie B</a>, <a href="/search?value1=James+Kavanagh&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Kavanagh James</a>, <a href="/search?value1=Kevin+K+Chau&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Chau Kevin K</a>, <a href="/search?value1=Louise+O+Downs&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Downs Louise O</a>, <a href="/search?value1=Stuart+Cox&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Cox Stuart</a>, <a href="/search?value1=Laura+Dunn&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Dunn Laura</a>, <a href="/search?value1=Anita+Justice&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Justice Anita</a>, <a href="/search?value1=Susan+Wareing&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Wareing Susan</a>, <a href="/search?value1=Kate+Dingle&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Dingle Kate</a>, <a href="/search?value1=Justine+Rudkin&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Rudkin Justine</a>, <a href="/search?value1=Kathryn+Auckland&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Auckland Kathryn</a>, <a href="/search?value1=Alexander+Fyfe&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Fyfe Alexander</a>, <a href="/search?value1=Jai+Bolton&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Bolton Jai</a>, <a href="/search?value1=Robert+Paton&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Paton Robert</a>, <a href="/search?value1=Alexander+J+Mentzer&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Mentzer Alexander J</a>, <a href="/search?value1=Katie+Jeffery&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Jeffery Katie</a>, <a href="/search?value1=Monique+I+Andersson&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Andersson Monique I</a>, <a href="/search?value1=Tim+James&option1=author&noRedirect=true" class="nonDisambigAuthorLink">James Tim</a>, <a href="/search?value1=Tim+E+A+Peto&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Peto Tim E A</a>, <a href="/search?value1=Brian+D+Marsden&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Marsden Brian D</a>, <a href="/search?value1=Gavin+Screaton&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Screaton Gavin</a>, <a href="/search?value1=Richard+J+Cornall&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Cornall Richard J</a>, <a href="/search?value1=Paul+Klenerman&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Klenerman Paul</a>, <a href="/search?value1=Daniel+Ebner&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Ebner Daniel</a>, <a href="/search?value1=David+I+Stuart&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Stuart David I</a>, <a href="/search?value1=Derrick+W+Crook&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Crook Derrick W</a>, <a href="/search?value1=Nicole+Stoesser&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Stoesser Nicole</a>, <a href="/search?value1=Stephen+H+Kennedy&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Kennedy Stephen H</a>, <a href="/search?value1=Craig+Thompson&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Thompson Craig</a>, <a href="/search?value1=Sunetra+Gupta&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Gupta Sunetra</a>, <a href="/search?value1=Philippa+C+Matthews&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Matthews Philippa C</a></span>. SARS-CoV-2 antibody prevalence, titres and neutralising activity in an antenatal cohort, United Kingdom, 14 April to 15 June 2020. <a href="/content/ecdc">Euro Surveill.</a> 2020;25(42):pii=2001721. <a href="https://doi.org/10.2807/1560-7917.ES.2020.25.41.2001721" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2020.25.41.2001721</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 24 Sept 2020;&nbsp;&nbsp; <span class="generated">Accepted</span>: 22 Oct 2020 </span> </p>
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