1887
  1. Home
  2. Eurosurveillance
  3. Volume 25, Issue 42, 22/Oct/2020
  4. Article
Rapid communication Open Access
Like 0
Download

Abstract

SARS-CoV-2 IgG screening of 1,000 antenatal serum samples in the Oxford area, United Kingdom, between 14 April and 15 June 2020, yielded a 5.3% seroprevalence, mirroring contemporaneous regional data. Among the 53 positive samples, 39 showed in vitro neutralisation activity, correlating with IgG titre (Pearson’s correlation p<0.0001). While SARS-CoV-2 seroprevalence in pregnancy cohorts could potentially inform population surveillance, clinical correlates of infection and immunity in pregnancy, and antenatal epidemiology evolution over time need further study.

© Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Loading

Article metrics loading...

/content/10.2807/1560-7917.ES.2020.25.41.2001721
2020-10-22
2024-12-26
/content/10.2807/1560-7917.ES.2020.25.41.2001721
Loading
Loading full text...

Full text loading...

/deliver/fulltext/eurosurveillance/25/42/eurosurv-25-42-4.html?itemId=/content/10.2807/1560-7917.ES.2020.25.41.2001721&mimeType=html&fmt=ahah

References

  1. Statistical bulletin: Coronavirus (COVID-19) Infection Survey pilot: England, 25 June 2020. Office for National Statistics, in partnership with IQVIA, Oxford University and UK Biocentre. Available from: https://www.ons.gov.uk/peoplepopulationandcommunity/healthandsocialcare/conditionsanddiseases/bulletins/coronaviruscovid19infectionsurveypilot/latest
  2. Emmenegger M, De Cecco E, Lamparter D, Jacquat RPB, Ebner D, Schneider MM, et al. Early plateau of SARS-CoV-2 seroprevalence identified by tripartite immunoassay in a large population. medRxiv. 2020; 2020.05.31.20118554.
  3. National SARS-CoV-2 Serology Assay Evaluation Group. Performance characteristics of five immunoassays for SARS-CoV-2: a head-to-head benchmark comparison. Lancet Infect Dis. 2020;S1473-3099(20)30634-4. PMID: 32979318 
  4. Thompson C, Grayson N, Paton R, Lourenço J, Penman B, Lee LN, et al. Neutralising antibodies to SARS coronavirus 2 in Scottish blood donors - a pilot study of the value of serology to determine population exposure. Infectious Diseases (except HIV/AIDS). medRxiv; 2020. doi: https://doi.org/10.1101/2020.04.13.20060467 
  5. Nie J, Li Q, Wu J, Zhao C, Hao H, Liu H, et al. Establishment and validation of a pseudovirus neutralization assay for SARS-CoV-2. Emerg Microbes Infect. 2020;9(1):680-6.  https://doi.org/10.1080/22221751.2020.1743767  PMID: 32207377 
  6. Suthar MS, Zimmerman MG, Kauffman RC, Mantus G, Linderman SL, Hudson WH, et al. Rapid Generation of Neutralizing Antibody Responses in COVID-19 Patients. Cell Rep Med. 2020;1(3):100040.  https://doi.org/10.1016/j.xcrm.2020.100040  PMID: 32835303 
  7. Peterhoff D, Glück V, Vogel M, Schuster P, Schütz A, Neubert P, et al. A highly specific and sensitive serological assay detects SARS-CoV-2 antibody levels in COVID-19 patients that correlate with neutralization. Infection. 2020.  https://doi.org/10.1007/s15010-020-01503-7  PMID: 32827125 
  8. Sood N, Simon P, Ebner P, Eichner D, Reynolds J, Bendavid E, et al. Seroprevalence of SARS-CoV-2-Specific Antibodies Among Adults in Los Angeles County, California, on April 10-11, 2020. JAMA. 2020;323(23):2425-7.  https://doi.org/10.1001/jama.2020.8279  PMID: 32421144 
  9. Percivalle E, Cambiè G, Cassaniti I, Nepita EV, Maserati R, Ferrari A, et al. Prevalence of SARS-CoV-2 specific neutralising antibodies in blood donors from the Lodi Red Zone in Lombardy, Italy, as at 06 April 2020. Euro Surveill. 2020;25(24):2001031.  https://doi.org/10.2807/1560-7917.ES.2020.25.24.2001031  PMID: 32583766 
  10. Eyre DW, Lumley SF, O’Donnell D, Campbell M, Sims E, Lawson E, et al. , Oxford University Hospitals Staff Testing Group. Differential occupational risks to healthcare workers from SARS-CoV-2 observed during a prospective observational study. eLife. 2020;9:e60675.  https://doi.org/10.7554/eLife.60675  PMID: 32820721 
  11. Deeks JJ, Dinnes J, Takwoingi Y, Davenport C, Spijker R, Taylor-Phillips S, et al. , Cochrane COVID-19 Diagnostic Test Accuracy Group. Antibody tests for identification of current and past infection with SARS-CoV-2. Cochrane Database Syst Rev. 2020;6:CD013652. PMID: 32584464 
  12. Buekens P, Alger J, Bréart G, Cafferata ML, Harville E, Tomasso G. A call for action for COVID-19 surveillance and research during pregnancy. Lancet Glob Health. 2020;8(7):e877-8.  https://doi.org/10.1016/S2214-109X(20)30206-0  PMID: 32333854 
  13. Corbett GA, Milne SJ, Hehir MP, Lindow SW, O’connell MP. Health anxiety and behavioural changes of pregnant women during the COVID-19 pandemic. Eur J Obstet Gynecol Reprod Biol. 2020;249:96-7.  https://doi.org/10.1016/j.ejogrb.2020.04.022  PMID: 32317197 
  14. Mattern J, Vauloup-Fellous C, Zakaria H, Benachi A, Carrara J, Letourneau A, et al. Post lockdown COVID-19 seroprevalence and circulation at the time of delivery, France. Infectious Diseases (except HIV/AIDS). medRxiv; 2020. doi: https://doi.org/10.1101/2020.07.14.20153304 
  15. Cosma S, Borella F, Carosso A, Sciarrone A, Cusato J, Corcione S, et al. The "scar" of a pandemic: Cumulative incidence of COVID-19 during the first trimester of pregnancy. J Med Virol. 2020;jmv.26267.  https://doi.org/10.1002/jmv.26267  PMID: 32633869 
  16. Crovetto F, Crispi F, Llurba E, Figueras F, Gómez-Roig MD, Gratacós E. Seroprevalence and presentation of SARS-CoV-2 in pregnancy. Lancet. 2020;396(10250):530-1.  https://doi.org/10.1016/S0140-6736(20)31714-1  PMID: 32771084 
  17. Galang RR, Chang K, Strid P, Snead MC, Woodworth KR, House LD, et al. Severe Coronavirus Infections in Pregnancy: A Systematic Review. Obstet Gynecol. 2020;136(2):262-72.  https://doi.org/10.1097/AOG.0000000000004011  PMID: 32544146 
  18. Cohen J, Vignaux O, Jacquemard F. Covid-19 in pregnant women: General data from a French National Survey. Eur J Obstet Gynecol Reprod Biol. 2020;251:267-8.  https://doi.org/10.1016/j.ejogrb.2020.06.002  PMID: 32540156 
  19. Maleki Dana P, Kolahdooz F, Sadoughi F, Moazzami B, Chaichian S, Asemi Z. COVID-19 and pregnancy: a review of current knowledge. Infez Med. 2020;28(suppl 1):46-51. PMID: 32532938 
  20. Maraschini A, Corsi E, Salvatore MA, Donati S. Coronavirus and birth in Italy: results of a national population-based cohort study. Obstetrics and Gynecology. medRxiv; 2020. doi: https://doi.org/10.1101/2020.06.11.20128652 
  21. INTERCOVID • INTERGROWTH-21st. [Accessed 1 Jul 2020]. Available from: https://intergrowth21.tghn.org/intercovid/
  22. Coronavirus (COVID-19) in the UK. [Accessed 16 Sep 2020]. Available from: https://coronavirus.data.gov.uk/cases
  23. World Health Organization (WHO). WHO Coronavirus Disease (COVID-19) Dashboard. Geneva: WHO. [Accessed 16 Sep 2020]. Available from: https://covid19.who.int/
SARS-CoV-2 antibody prevalence, titres and neutralising activity in an antenatal cohort, United Kingdom, 14 April to 15 June 2020
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=Sheila+F+Lumley&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Lumley Sheila F</a>, <a href="/search?value1=David+W+Eyre&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Eyre David W</a>, <a href="/search?value1=Anna+L+McNaughton&option1=author&noRedirect=true" class="nonDisambigAuthorLink">McNaughton Anna L</a>, <a href="/search?value1=Alison+Howarth&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Howarth Alison</a>, <a href="/search?value1=Sarah+Hoosdally&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Hoosdally Sarah</a>, <a href="/search?value1=Stephanie+B+Hatch&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Hatch Stephanie B</a>, <a href="/search?value1=James+Kavanagh&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Kavanagh James</a>, <a href="/search?value1=Kevin+K+Chau&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Chau Kevin K</a>, <a href="/search?value1=Louise+O+Downs&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Downs Louise O</a>, <a href="/search?value1=Stuart+Cox&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Cox Stuart</a>, <a href="/search?value1=Laura+Dunn&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Dunn Laura</a>, <a href="/search?value1=Anita+Justice&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Justice Anita</a>, <a href="/search?value1=Susan+Wareing&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Wareing Susan</a>, <a href="/search?value1=Kate+Dingle&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Dingle Kate</a>, <a href="/search?value1=Justine+Rudkin&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Rudkin Justine</a>, <a href="/search?value1=Kathryn+Auckland&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Auckland Kathryn</a>, <a href="/search?value1=Alexander+Fyfe&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Fyfe Alexander</a>, <a href="/search?value1=Jai+Bolton&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Bolton Jai</a>, <a href="/search?value1=Robert+Paton&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Paton Robert</a>, <a href="/search?value1=Alexander+J+Mentzer&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Mentzer Alexander J</a>, <a href="/search?value1=Katie+Jeffery&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Jeffery Katie</a>, <a href="/search?value1=Monique+I+Andersson&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Andersson Monique I</a>, <a href="/search?value1=Tim+James&option1=author&noRedirect=true" class="nonDisambigAuthorLink">James Tim</a>, <a href="/search?value1=Tim+E+A+Peto&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Peto Tim E A</a>, <a href="/search?value1=Brian+D+Marsden&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Marsden Brian D</a>, <a href="/search?value1=Gavin+Screaton&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Screaton Gavin</a>, <a href="/search?value1=Richard+J+Cornall&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Cornall Richard J</a>, <a href="/search?value1=Paul+Klenerman&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Klenerman Paul</a>, <a href="/search?value1=Daniel+Ebner&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Ebner Daniel</a>, <a href="/search?value1=David+I+Stuart&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Stuart David I</a>, <a href="/search?value1=Derrick+W+Crook&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Crook Derrick W</a>, <a href="/search?value1=Nicole+Stoesser&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Stoesser Nicole</a>, <a href="/search?value1=Stephen+H+Kennedy&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Kennedy Stephen H</a>, <a href="/search?value1=Craig+Thompson&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Thompson Craig</a>, <a href="/search?value1=Sunetra+Gupta&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Gupta Sunetra</a>, <a href="/search?value1=Philippa+C+Matthews&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Matthews Philippa C</a></span>. SARS-CoV-2 antibody prevalence, titres and neutralising activity in an antenatal cohort, United Kingdom, 14 April to 15 June 2020. <a href="/content/ecdc">Euro Surveill.</a> 2020;25(42):pii=2001721. <a href="https://doi.org/10.2807/1560-7917.ES.2020.25.41.2001721" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2020.25.41.2001721</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 24 Sept 2020;&nbsp;&nbsp; <span class="generated">Accepted</span>: 22 Oct 2020 </span> </p>
/content/10.2807/1560-7917.ES.2020.25.41.2001721
/content/10.2807/1560-7917.ES.2020.25.41.2001721
Loading

Data & Media loading...

Supplementary data

Submit comment
Close
Comment moderation successfully completed
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error