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Abstract

Background

Respiratory syncytial virus (RSV) is a common cause of severe respiratory illness in young children (< 5 years old) and older adults (≥ 65 years old) leading the World Health Organization (WHO) to recommend the implementation of a dedicated surveillance in countries.

Aim

We tested the capacity of the severe acute respiratory infection (SARI) hospital network to contribute to RSV surveillance in Belgium.

Methods

During the 2018/19 influenza season, we started the SARI surveillance for influenza in Belgium in week 40, earlier than in the past, to follow RSV activity, which usually precedes influenza virus circulation. While the WHO SARI case definition for influenza normally used by the SARI hospital network was employed, flexibility over the fever criterion was allowed, so patients without fever but meeting the other case definition criteria could be included in the surveillance.

Results

Between weeks 40 2018 and 2 2019, we received 508 samples from SARI patients. We found an overall RSV detection rate of 62.4% (317/508), with rates varying depending on the age group: 77.6% in children aged < 5 years (253/326) and 34.4% in adults aged ≥ 65 years (44/128). Over 90% of the RSV-positive samples also positive for another tested respiratory virus (80/85) were from children aged < 5 years. Differences were also noted between age groups for symptoms, comorbidities and complications.

Conclusion

With only marginal modifications in the case definition and the period of surveillance, the Belgian SARI network would be able to substantially contribute to RSV surveillance and burden evaluation in children and older adults, the two groups of particular interest for WHO.

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This work is licensed under a Creative Commons Attribution 4.0 International License.
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2020-10-01
2024-12-23
/content/10.2807/1560-7917.ES.2020.25.39.1900627
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References

  1. Stein RT, Bont LJ, Zar H, Polack FP, Park C, Claxton A, et al. Respiratory syncytial virus hospitalization and mortality: Systematic review and meta-analysis. Pediatr Pulmonol. 2017;52(4):556-69.  https://doi.org/10.1002/ppul.23570  PMID: 27740723 
  2. Shi T, McAllister DA, O’Brien KL, Simoes EAF, Madhi SA, Gessner BD, et al. , RSV Global Epidemiology Network. Global, regional, and national disease burden estimates of acute lower respiratory infections due to respiratory syncytial virus in young children in 2015: a systematic review and modelling study. Lancet. 2017;390(10098):946-58.  https://doi.org/10.1016/S0140-6736(17)30938-8  PMID: 28689664 
  3. Ackerson B, Tseng HF, Sy LS, Solano Z, Slezak J, Luo Y, et al. Severe Morbidity and Mortality Associated With Respiratory Syncytial Virus Versus Influenza Infection in Hospitalized Older Adults. Clin Infect Dis. 2019;69(2):197-203.  https://doi.org/10.1093/cid/ciy991  PMID: 30452608 
  4. Falsey AR, Hennessey PA, Formica MA, Cox C, Walsh EE. Respiratory syncytial virus infection in elderly and high-risk adults. N Engl J Med. 2005;352(17):1749-59.  https://doi.org/10.1056/NEJMoa043951  PMID: 15858184 
  5. Shi T, Denouel A, Tietjen AK, Campbell I, Moran E, Li X, et al. , RESCEU Investigators. Global Disease Burden Estimates of Respiratory Syncytial Virus-Associated Acute Respiratory Infection in Older Adults in 2015: A Systematic Review and Meta-Analysis. J Infect Dis. 2019;352(17):jiz059.  https://doi.org/10.1093/infdis/jiz059  PMID: 30880339 
  6. European Medicines Agency. Synagis. Amsterdam: EMA. [Accessed Sep 2019]. Available from: https://www.ema.europa.eu/en/medicines/human/EPAR/synagis#authorisation-details-section
  7. ClinicalTrials.gov. Respiratory Syncytial Virus. [Accessed Sep 2019]. Available from: https://clinicaltrials.gov/ct2/results?cond=Respiratory+Syncytial+Virus+%28RSV%29&term=&cntry=&state=&city=&dist=&Search=Search
  8. EU Clinical Trials Register. Clinical trials for Respiratory Syncytial Virus (RSV). [Accessed Sep 2019]. Available from: https://www.clinicaltrialsregister.eu/ctr-search/search?query=Respiratory+Syncytial+Virus+(RSV)
  9. Mejias A, Rodriguez-Fernandez R, Peeples ME, Ramilo O. Respiratory Syncytial Virus Vaccines: Are We Making Progress? Pediatr Infect Dis J. 2019;38(10):e266-9.  https://doi.org/10.1097/INF.0000000000002404  PMID: 31335571 
  10. World Health Organization (WHO). WHO strategy to pilot global respiratory syncytial virus surveillance based on the Global Influenza Surveillance and Response System (‎GISRS)‎. Geneva: WHO; 2017. Available from: https://apps.who.int/iris/handle/10665/25985
  11. Sciensano. Respiratory Syncytial Virus. 2019. Available from: https://epidemio.wiv-isp.be/ID/diseases/Pages/RSV.aspx
  12. Obando-Pacheco P, Justicia-Grande AJ, Rivero-Calle I, Rodríguez-Tenreiro C, Sly P, Ramilo O, et al. Respiratory Syncytial Virus Seasonality: A Global Overview. J Infect Dis. 2018;217(9):1356-64.  https://doi.org/10.1093/infdis/jiy056  PMID: 29390105 
  13. Broberg EK, Waris M, Johansen K, Snacken R, Penttinen P, Network EIS, European Influenza Surveillance Network. Seasonality and geographical spread of respiratory syncytial virus epidemics in 15 European countries, 2010 to 2016. Euro Surveill. 2018;23(5):17-00284.  https://doi.org/10.2807/1560-7917.ES.2018.23.5.17-00284  PMID: 29409569 
  14. Broor S, Campbell H, Hirve S, Hague S, Jackson S, Moen A, et al. Leveraging the Global Influenza Surveillance and Response System for global respiratory syncytial virus surveillance-opportunities and challenges. Influenza Other Respi Viruses. 2019;10.1111/irv.12672.  https://doi.org/10.1111/irv.12672  PMID: 31444997 
  15. World Health Organization (WHO). WHO meeting of mid-term review of the RSV surveillance pilot based on the global influenza surveillance and response system, PAHO, Washington DC, USA, 18 – 20 December 2017. Geneva: WHO; 2019. Available from: https://apps.who.int/iris/handle/10665/311960
  16. Ma X, Conrad T, Alchikh M, Reiche J, Schweiger B, Rath B. Can we distinguish respiratory viral infections based on clinical features? A prospective pediatric cohort compared to systematic literature review. Rev Med Virol. 2018;28(5):e1997.  https://doi.org/10.1002/rmv.1997  PMID: 30043515 
  17. Vos LM, Teirlinck AC, Lozano JE, Vega T, Donker GA, Hoepelman AI, et al. Use of the moving epidemic method (MEM) to assess national surveillance data for respiratory syncytial virus (RSV) in the Netherlands, 2005 to 2017. Euro Surveill. 2019;24(20):1800469.  https://doi.org/10.2807/1560-7917.ES.2019.24.20.1800469  PMID: 31115311 
  18. Hirsh S, Hindiyeh M, Kolet L, Regev L, Sherbany H, Yaary K, et al. Epidemiological changes of respiratory syncytial virus (RSV) infections in Israel. PLoS One. 2014;9(3):e90515.  https://doi.org/10.1371/journal.pone.0090515  PMID: 24594694 
  19. Sáez-López E, Pechirra P, Costa I, Cristóvão P, Conde P, Machado A, et al. Performance of surveillance case definitions for respiratory syncytial virus infections through the sentinel influenza surveillance system, Portugal, 2010 to 2018. Euro Surveill. 2019;24(45):1900140.  https://doi.org/10.2807/1560-7917.ES.2019.24.45.1900140  PMID: 31718741 
  20. Rha B, Dahl RM, Moyes J, Binder AM, Tempia S, Walaza S, et al. Performance of Surveillance Case Definitions in Detecting Respiratory Syncytial Virus Infection Among Young Children Hospitalized With Severe Respiratory Illness-South Africa, 2009-2014. J Pediatric Infect Dis Soc. 2019;8(4):325-33.  https://doi.org/10.1093/jpids/piy055  PMID: 29931284 
  21. Kneyber MCJ, Brandenburg AH, de Groot R, Joosten KFM, Rothbarth PH, Ott A, et al. Risk factors for respiratory syncytial virus associated apnoea. Eur J Pediatr. 1998;157(4):331-5.  https://doi.org/10.1007/s004310050822  PMID: 9578972 
  22. Geoghegan S, Erviti A, Caballero MT, Vallone F, Zanone SM, Losada JV, et al. Mortality due to respiratory syncytial virus burden and risk factors. Am J Respir Crit Care Med. 2017;195(1):96-103.  https://doi.org/10.1164/rccm.201603-0658OC  PMID: 27331632 
  23. Jeannoël M, Lina G, Rasigade JP, Lina B, Morfin F, Casalegno JS. Microorganisms associated with respiratory syncytial virus pneumonia in the adult population. Eur J Clin Microbiol Infect Dis. 2019;38(1):157-60.  https://doi.org/10.1007/s10096-018-3407-3  PMID: 30353485 
  24. Bordi L, Nicastri E, Scorzolini L, Di Caro A, Capobianchi MR, Castilletti C, et al. , On Behalf Of Inmi Covid-Study Group And Collaborating Centers. Differential diagnosis of illness in patients under investigation for the novel coronavirus (SARS-CoV-2), Italy, February 2020. Euro Surveill. 2020;25(8):2000170.  https://doi.org/10.2807/1560-7917.ES.2020.25.8.2000170  PMID: 32127123 
  25. Uddin SMI, Englund JA, Kuypers JY, Chu HY, Steinhoff MC, Khatry SK, et al. Burden and risk factors for coronavirus infections in infants in rural Nepal. Clin Infect Dis. 2018;67(10):1507-14.  https://doi.org/10.1093/cid/ciy317  PMID: 29668900 
  26. Hahn A, Wang W, Jaggi P, Dvorchik I, Ramilo O, Koranyi K, et al. Human metapneumovirus infections are associated with severe morbidity in hospitalized children of all ages. Epidemiol Infect. 2013;141(10):2213-23.  https://doi.org/10.1017/S0950268812002920  PMID: 23290557 
  27. Li Y, Reeves RM, Wang X, Bassat Q, Brooks WA, Cohen C, et al. , RSV Global Epidemiology Network, RESCEU investigators. Global patterns in monthly activity of influenza virus, respiratory syncytial virus, parainfluenza virus, and metapneumovirus: a systematic analysis. Lancet Glob Health. 2019;7(8):e1031-45.  https://doi.org/10.1016/S2214-109X(19)30264-5  PMID: 31303294 
Capturing respiratory syncytial virus season in Belgium using the influenza severe acute respiratory infection surveillance network, season 2018/19
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=Lorenzo+Subissi&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Subissi Lorenzo</a>, <a href="/search?value1=Nathalie+Bossuyt&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Bossuyt Nathalie</a>, <a href="/search?value1=Marijke+Reynders&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Reynders Marijke</a>, <a href="/search?value1=Mich%C3%A8le+G%C3%A9rard&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Gérard Michèle</a>, <a href="/search?value1=Nicolas+Dauby&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Dauby Nicolas</a>, <a href="/search?value1=Marc+Bourgeois&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Bourgeois Marc</a>, <a href="/search?value1=B%C3%A9n%C3%A9dicte+Delaere&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Delaere Bénédicte</a>, <a href="/search?value1=Sophie+Quoilin&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Quoilin Sophie</a>, <a href="/search?value1=Steven+Van+Gucht&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Van Gucht Steven</a>, <a href="/search?value1=Isabelle+Thomas&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Thomas Isabelle</a>, <a href="/search?value1=Cyril+Barbezange&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Barbezange Cyril</a></span>. Capturing respiratory syncytial virus season in Belgium using the influenza severe acute respiratory infection surveillance network, season 2018/19. <a href="/content/ecdc">Euro Surveill.</a> 2020;25(39):pii=1900627. <a href="https://doi.org/10.2807/1560-7917.ES.2020.25.39.1900627" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2020.25.39.1900627</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 16 Oct 2019;&nbsp;&nbsp; <span class="generated">Accepted</span>: 12 Aug 2020 </span> </p>
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