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Abstract

Background

Vancomycin-resistant enterococci (VRE), mostly , are multidrug-resistant microorganisms that can cause nosocomial infections. VRE has increased throughout many European countries, but data from Switzerland are scarce.

Aim

The aim of this work was to characterise the epidemiology of enterococcal bacteraemias in Switzerland with a focus on VRE.

Methods

In this observational study, we retrospectively investigated bacteraemias from 81 healthcare institutions from January 2013 to December 2018 using data from the Swiss Centre for Antibiotic Resistance. Only the first blood isolate with or from an individual patient was considered. We analysed the annual incidences of enterococcal bacteraemias and determined the proportion of VRE over time. We also assessed epidemiological factors potentially associated with VRE bacteraemia.

Results

We identified 5,369 enterococcal bacteraemias, of which 3,196 (59.5%) were due to and 2,173 (40.5%) to . The incidence of enterococcal bacteraemias increased by 3.2% per year (95% confidential interval (CI): 1.6–4.8%), predominantly due to a substantial increase in bacteraemic episodes. Vancomycin resistance affected 30 (1.4%) and one bacteraemic episodes. Among all bacteraemias, the proportion of vancomycin-resistant isolates increased steadily from 2013 to 2018 (2% per year; 95% CI: 1.5–2.9%). No independent epidemiological factor for higher prevalence of vancomycin-resistant bacteraemias was identified.

Conclusions

Vancomycin-resistant bacteraemias remain infrequent in Switzerland. However, an important increase was observed between 2013 and 2018, highlighting the need for implementing active surveillance and targeted prevention strategies in the country.

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This work is licensed under a Creative Commons Attribution 4.0 International License.
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2020-09-03
2024-11-21
http://instance.metastore.ingenta.com/content/10.2807/1560-7917.ES.2020.25.35.1900575
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Increasing proportion of vancomycin resistance among enterococcal bacteraemias in Switzerland: a 6-year nation-wide surveillance, 2013 to 2018
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=Vanja+Piezzi&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Piezzi Vanja</a>, <a href="/search?value1=Michael+Gasser&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Gasser Michael</a>, <a href="/search?value1=Andrew+Atkinson&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Atkinson Andrew</a>, <a href="/search?value1=Andreas+Kronenberg&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Kronenberg Andreas</a>, <a href="/search?value1=Danielle+Vuichard-Gysin&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Vuichard-Gysin Danielle</a>, <a href="/search?value1=Stephan+Harbarth&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Harbarth Stephan</a>, <a href="/search?value1=Jonas+Marschall&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Marschall Jonas</a>, <a href="/search?value1=Niccol%C3%B2+Buetti&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Buetti Niccolò</a>, <a href="/search?value1=on+behalf+of+the+Swiss+Centre+for+Antibiotic+Resistance+%28ANRESIS%29&option1=author&noRedirect=true" class="nonDisambigAuthorLink">on behalf of the Swiss Centre for Antibiotic Resistance (ANRESIS)</a>, <a href="/search?value1=on+behalf+of+the+National+Centre+for+Infection+Control+%28Swissnoso%29&option1=author&noRedirect=true" class="nonDisambigAuthorLink">on behalf of the National Centre for Infection Control (Swissnoso)</a></span>. Increasing proportion of vancomycin resistance among enterococcal bacteraemias in Switzerland: a 6-year nation-wide surveillance, 2013 to 2018. <a href="/content/ecdc">Euro Surveill.</a> 2020;25(35):pii=1900575. <a href="https://doi.org/10.2807/1560-7917.ES.2020.25.35.1900575" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2020.25.35.1900575</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 16 Sept 2019;&nbsp;&nbsp; <span class="generated">Accepted</span>: 16 Feb 2020 </span> </p>
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