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Abstract

Serological reactivity was analysed in plasma from 436 individuals with a history of disease compatible with COVID-19, including 256 who had been laboratory-confirmed with SARS-CoV-2 infection. Over 99% of laboratory-confirmed cases developed a measurable antibody response (254/256) and 88% harboured neutralising antibodies (226/256). Antibody levels declined over 3 months following diagnosis, emphasising the importance of the timing of convalescent plasma collections. Binding antibody measurements can inform selection of convalescent plasma donors with high neutralising antibody levels.

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/content/10.2807/1560-7917.ES.2020.25.28.2001260
2020-07-16
2024-11-23
http://instance.metastore.ingenta.com/content/10.2807/1560-7917.ES.2020.25.28.2001260
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Convalescent plasma treatment for SARS-CoV-2 infection: analysis of the first 436 donors in England, 22 April to 12 May 2020
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=Heli+Harvala&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Harvala Heli</a>, <a href="/search?value1=Jennifer+Mehew&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Mehew Jennifer</a>, <a href="/search?value1=Matthew+L+Robb&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Robb Matthew L</a>, <a href="/search?value1=Samreen+Ijaz&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Ijaz Samreen</a>, <a href="/search?value1=Steven+Dicks&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Dicks Steven</a>, <a href="/search?value1=Monika+Patel&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Patel Monika</a>, <a href="/search?value1=Nicholas+Watkins&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Watkins Nicholas</a>, <a href="/search?value1=Peter+Simmonds&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Simmonds Peter</a>, <a href="/search?value1=Tim+Brooks&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Brooks Tim</a>, <a href="/search?value1=Rachel+Johnson&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Johnson Rachel</a>, <a href="/search?value1=Robin+Gopal&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Gopal Robin</a>, <a href="/search?value1=David+J+Roberts&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Roberts David J</a>, <a href="/search?value1=Maria+Zambon&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Zambon Maria</a>, <a href="/search?value1=the+NHS+Blood+and+Transplant+Convalescent+Plasma+Testing+Group&option1=author&noRedirect=true" class="nonDisambigAuthorLink">the NHS Blood and Transplant Convalescent Plasma Testing Group</a></span>. Convalescent plasma treatment for SARS-CoV-2 infection: analysis of the first 436 donors in England, 22 April to 12 May 2020. <a href="/content/ecdc">Euro Surveill.</a> 2020;25(28):pii=2001260. <a href="https://doi.org/10.2807/1560-7917.ES.2020.25.28.2001260" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2020.25.28.2001260</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 22 Jun 2020;&nbsp;&nbsp; <span class="generated">Accepted</span>: 16 Jul 2020 </span> </p>
/content/10.2807/1560-7917.ES.2020.25.28.2001260
/content/10.2807/1560-7917.ES.2020.25.28.2001260
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