-
Cross-border spread of blaNDM-1- and blaOXA-48-positive Klebsiella pneumoniae: a European collaborative analysis of whole genome sequencing and epidemiological data, 2014 to 2019
- Catherine Ludden1 , Felix Lötsch1 , Erik Alm1 , Narender Kumar2 , Karin Johansson1 , Barbara Albiger1 , Te-Din Huang3 , Olivier Denis3 , Anette M Hammerum4 , Henrik Hasman4 , Jari Jalava5 , Kati Räisänen5 , Laurent Dortet6 , Agnès B Jousset6 , Sören Gatermann7 , Sebastian Haller8 , Martin Cormican9 , Wendy Brennan9 , Maria Del Grosso10 , Monica Monaco10 , Leo Schouls11 , Ørjan Samuelsen12,13 , Mateja Pirš14 , Tjaša Cerar14 , Jésus Oteo-Iglesias15 , Maria Pérez-Vázquez15 , Karin Sjöström16 , Petra Edquist16 , Katie L Hopkins17 , Marc J Struelens1 , Daniel Palm1 , Dominique L Monnet1 , Anke Kohlenberg1
-
View Affiliations Hide AffiliationsAffiliations: 1 European Centre for Disease Prevention and Control, Stockholm, Sweden 2 Department of Medicine, University of Cambridge, Cambridge, United Kingdom 3 Belgian National Reference Center for Antibiotic-resistant Gram-negative bacilli, CHU UCL Namur, UCLouvain, Yvoir, Belgium 4 Department of Bacteria, Parasites and Fungi, Statens Serum Institut, Copenhagen, Denmark 5 Department of Health Security, Finnish Institute for Health and Welfare, Helsinki, Finland 6 French National Reference Center for Antimicrobial Resistance, INSERM UMR 1184, Paris-Saclay University, Bicêtre hospital, Assistance Publique des Hôpitaux de Paris, Paris, France 7 National Reference Centre for multidrug-resistant Gram-negative bacteria, Ruhr University Bochum, Bochum, Germany 8 Robert Koch Institute, Department for Infectious Disease Epidemiology, Berlin, Germany 9 National University of Ireland, Galway, Ireland 10 Department of Infectious Diseases, Istituto Superiore di Sanità, Rome, Italy 11 Infectious Diseases Research, Diagnostics and Laboratory Surveillance, National Institute for Public Health and the Environment, Bilthoven, the Netherlands 12 Norwegian National Advisory Unit on Detection of Antimicrobial Resistance, University Hospital of North Norway, Tromsø, Norway 13 Department of Pharmacy, Faculty of Health Sciences, UiT The Arctic University of Norway, Tromsø, Norway 14 Institute of Microbiology and Immunology, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia 15 Laboratorio de Referencia e Investigación en Resistencia a Antibióticos e Infecciones Relacionadas con la Asistencia Sanitaria, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Madrid, Spain 16 Public Health Agency of Sweden, Stockholm, Sweden 17 Healthcare Associated Infections and Antimicrobial Resistance Division, National Infection Service, Public Health England, London, United KingdomAnke Kohlenberganke.kohlenberg ecdc.europa.eu
-
View Citation Hide Citation
Citation style for this article: Ludden Catherine, Lötsch Felix, Alm Erik, Kumar Narender, Johansson Karin, Albiger Barbara, Huang Te-Din, Denis Olivier, Hammerum Anette M, Hasman Henrik, Jalava Jari, Räisänen Kati, Dortet Laurent, Jousset Agnès B, Gatermann Sören, Haller Sebastian, Cormican Martin, Brennan Wendy, Del Grosso Maria, Monaco Monica, Schouls Leo, Samuelsen Ørjan, Pirš Mateja, Cerar Tjaša, Oteo-Iglesias Jésus, Pérez-Vázquez Maria, Sjöström Karin, Edquist Petra, Hopkins Katie L, Struelens Marc J, Palm Daniel, Monnet Dominique L, Kohlenberg Anke. Cross-border spread of blaNDM-1- and blaOXA-48-positive Klebsiella pneumoniae: a European collaborative analysis of whole genome sequencing and epidemiological data, 2014 to 2019. Euro Surveill. 2020;25(20):pii=2000627. https://doi.org/10.2807/1560-7917.ES.2020.25.20.2000627 Received: 15 Apr 2020; Accepted: 19 May 2020
Abstract
Analysis of sequencing data for 143 blaNDM-1- and blaOXA-48-positive Klebsiella pneumoniae isolates from 13 European national collections and the public domain resulted in the identification of 15 previously undetected multi-country transmission clusters. For 10 clusters, cases had prior travel/hospitalisation history in countries outside of the European Union including Egypt, Iran, Morocco, Russia, Serbia, Tunisia and Turkey. These findings highlight the benefit of European whole genome sequencing-based surveillance and data sharing for control of antimicrobial resistance.
Article metrics loading...
Full text loading...
References
-
European Centre for Disease Prevention and Control (ECDC). Rapid risk assessment: Outbreak of carbapenemase-producing (NDM-1 and OXA-48) and colistin-resistant Klebsiella pneumoniae ST307, north-east Germany, 2019. Stockholm: ECDC; 2019. Available from: https://www.ecdc.europa.eu/sites/default/files/documents/Klebsiella-pneumoniae-resistance-Germany-risk-assessment.pdf
-
Haller S, Kramer R, Becker K, Bohnert JA, Eckmanns T, Hans JB, et al. Extensively drug-resistant Klebsiella pneumoniae ST307 outbreak, north-eastern Germany, June to October 2019. Euro Surveill. 2019;24(50):1900734. https://doi.org/10.2807/1560-7917.ES.2019.24.50.1900734 PMID: 31847948
-
Kumar N, Raven KE, Blane B, Leek D, Brown NM, Bragin E, et al. Evaluation of a fully automated bioinformatics tool to predict antibiotic resistance from MRSA genomes. J Antimicrob Chemother. 2020;75(5):1117-22. https://doi.org/10.1093/jac/dkz570 PMID: 32025709
-
Interactive tree of life (iTOL) v3: an online tool for the display and annotation of phylogenetic and other trees. Heidelberg: EMBL. [Accessed: 7 May 2020]. Available from: https://itol.embl.de/
-
Zankari E, Hasman H, Cosentino S, Vestergaard M, Rasmussen S, Lund O, et al. Identification of acquired antimicrobial resistance genes. J Antimicrob Chemother. 2012;67(11):2640-4. https://doi.org/10.1093/jac/dks261 PMID: 22782487
-
Kleborate v0·3·0. San Francisco: GitHub. [Accessed: 16 Dec 2019]. Available from: https://github.com/katholt/Kleborate
-
European Nucleotide Archive. Study: PRJEB35890. European study on Klebsiella pneumoniae carrying both NDM-1 and OXA-48. Hinxton: The European Bioinformatics Institute (EMBL-EBI); 2020. Available from: www.ebi.ac.uk/ena/data/view/PRJEB35890
-
European Centre for Disease Prevention and Control (ECDC). Rapid risk assessment: Regional outbreak of New Delhi metallo-betalactamase-producing carbapenem-resistant Enterobacteriaceae, Italy, 2018-2019. Stockholm ECDC; 2019. Available from: https://ecdc.europa.eu/sites/portal/files/documents/04-Jun-2019-RRA-Carbapenems%2C%20Enterobacteriaceae-Italy.pdf
-
European Centre for Disease Prevention and Control (ECDC). Rapid risk assessment: Outbreak of carbapenemase-producing Enterobacterales in Lithuania, 2019. Stockholm: ECDC; 2019. Available from: https://www.ecdc.europa.eu/sites/default/files/documents/AMR-rapid-risk-assessment-outbreak%20-of-carbapenemase-producing-Enterobacterales-Lithuania.pdf
-
Shamina OV, Kryzhanovskaya OA, Lazareva AV, Alyabieva NM, Polikarpova SV, Karaseva OV, et al. Emergence of the ST307 clone carrying a novel insertion element MITEKpn1 in the mgrB gene among carbapenem-resistant Klebsiella pneumoniae from Moscow, Russia. Int J Antimicrob Agents. 2020;55(2):105850. https://doi.org/10.1016/j.ijantimicag.2019.11.007 PMID: 31770629
-
Barguigua A, El Otmani F, Lakbakbi El Yaagoubi F, Talmi M, Zerouali K, Timinouni M. First report of a Klebsiella pneumoniae strain coproducing NDM-1, VIM-1 and OXA-48 carbapenemases isolated in Morocco. APMIS. 2013;121(7):675-7. https://doi.org/10.1111/apm.12034 PMID: 23278254
-
Ben Nasr A, Decré D, Compain F, Genel N, Barguellil F, Arlet G. Emergence of NDM-1 in association with OXA-48 in Klebsiella pneumoniae from Tunisia. Antimicrob Agents Chemother. 2013;57(8):4089-90. https://doi.org/10.1128/AAC.00536-13 PMID: 23752514
-
Solgi H, Giske CG, Badmasti F, Aghamohammad S, Havaei SA, Sabeti S, et al. Emergence of carbapenem resistant Escherichia coli isolates producing blaNDM and blaOXA-48-like carried on IncA/C and IncL/M plasmids at two Iranian university hospitals. Infect Genet Evol. 2017;55:318-23. https://doi.org/10.1016/j.meegid.2017.10.003 PMID: 28987805
-
Khalifa HO, Soliman AM, Ahmed AM, Shimamoto T, Hara T, Ikeda M, et al. High carbapenem resistance in clinical gram-negative pathogens isolated in Egypt. Microb Drug Resist. 2017;23(7):838-44. https://doi.org/10.1089/mdr.2015.0339 PMID: 28191865
-
Cizmeci Z, Aktas E, Otlu B, Acikgoz O, Ordekci S. Molecular characterization of carbapenem- resistant Enterobacteriaceae yields increasing rates of NDM-1 carbapenemases and colistin resistance in an OXA-48- endemic area. J Chemother. 2017;29(6):344-50. https://doi.org/10.1080/1120009X.2017.1323149 PMID: 28486840
-
Revez J, Espinosa L, Albiger B, Leitmeyer KC, Struelens MJECDC National Microbiology Focal Points and Experts Group. Survey on the use of whole-genome sequencing for infectious diseases surveillance: rapid expansion of European national capacities, 2015-2016. Front Public Health. 2017;5:347. https://doi.org/10.3389/fpubh.2017.00347 PMID: 29326921
-
European Centre for Disease Prevention and Control (ECDC). Monitoring the use of whole-genome sequencing in infectious disease surveillance in Europe 2015–2017. Stockholm: ECDC; 2018. Available from: https://www.ecdc.europa.eu/sites/portal/files/documents/whole-genome-sequencing-infectious-disease-surveillance-Europe-2015-2017.pdf
Data & Media loading...