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Abstract

Background

COVID-19, caused by SARS-CoV-2, first appeared in China and subsequently developed into an ongoing epidemic. Understanding epidemiological factors characterising the transmission dynamics of this disease is of fundamental importance.

Aims

This study aimed to describe key epidemiological parameters of COVID-19 in Hong Kong.

Methods

We extracted data of confirmed COVID-19 cases and their close contacts from the publicly available information released by the Hong Kong Centre for Health Protection. We used doubly interval censored likelihood to estimate containment delay and serial interval, by fitting gamma, lognormal and Weibull distributions to respective empirical values using Bayesian framework with right truncation. A generalised linear regression model was employed to identify factors associated with containment delay. Secondary attack rate was also estimated.

Results

The empirical containment delay was 6.39 days; whereas after adjusting for right truncation with the best-fit Weibull distribution, it was 10.4 days (95% CrI: 7.15 to 19.81). Containment delay increased significantly over time. Local source of infection and number of doctor consultations before isolation were associated with longer containment delay. The empirical serial interval was 4.58–6.06 days; whereas the best-fit lognormal distribution to 26 certain-and-probable infector–infectee paired data gave an estimate of 4.77 days (95% CrI: 3.47 to 6.90) with right-truncation. The secondary attack rate among close contacts was 11.7%.

Conclusion

With a considerable containment delay and short serial interval, contact-tracing effectiveness may not be optimised to halt the transmission with rapid generations replacement. Our study highlights the transmission risk of social interaction and pivotal role of physical distancing in suppressing the epidemic.

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This work is licensed under a Creative Commons Attribution 4.0 International License.
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/content/10.2807/1560-7917.ES.2020.25.16.2000155
2020-04-23
2024-11-21
http://instance.metastore.ingenta.com/content/10.2807/1560-7917.ES.2020.25.16.2000155
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Epidemiological characteristics of the first 53 laboratory-confirmed cases of COVID-19 epidemic in Hong Kong, 13 February 2020
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=Kin+On+Kwok&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Kwok Kin On</a>, <a href="/search?value1=Valerie+Wing+Yu+Wong&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Wong Valerie Wing Yu</a>, <a href="/search?value1=Wan+In+Wei&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Wei Wan In</a>, <a href="/search?value1=Samuel+Yeung+Shan+Wong&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Wong Samuel Yeung Shan</a>, <a href="/search?value1=Julian+Wei-Tze+Tang&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Tang Julian Wei-Tze</a></span>. Epidemiological characteristics of the first 53 laboratory-confirmed cases of COVID-19 epidemic in Hong Kong, 13 February 2020. <a href="/content/ecdc">Euro Surveill.</a> 2020;25(16):pii=2000155. <a href="https://doi.org/10.2807/1560-7917.ES.2020.25.16.2000155" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2020.25.16.2000155</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 18 Feb 2020;&nbsp;&nbsp; <span class="generated">Accepted</span>: 14 Apr 2020 </span> </p>
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