1887
  1. Home
  2. Eurosurveillance
  3. Volume 25, Issue 10, 12/Mar/2020
  4. Article
Research Open Access
Like 0
Download

Abstract

Background

Crimean-Congo haemorrhagic fever virus (CCHFV) is considered an emerging or even a probable re-emerging pathogen in southern Europe. Presence of this virus had been reported previously in Spain in 2010.

Aim

We aimed to evaluate the potential circulation of CCHFV in western Spain with a serosurvey in asymptomatic adults (blood donors).

Methods

During 2017 and 2018, we conducted a CCHFV serosurvey in randomly selected asymptomatic blood donors from western Spain. Three assays using specific IgG antibodies against CCHFV were performed: the VectoCrimea ELISA test, an in-house ELISA and indirect immunofluorescence (EuroImmun) test with glycoprotein and nucleoprotein.

Results

A total of 516 blood donors participated in this cross-sectional study. The majority of the study participants were male (68.4%), and the mean age was 46.3 years. Most of the participants came from rural areas (86.8%) and 68.6% had contact with animals and 20.9% had animal husbandry practices. One in five participants (109/516, 21.1%) were engaged in at-risk professional activities such as agriculture and shepherding, slaughtering, hunting, veterinary and healthcare work (mainly nursing staff and laboratory technicians). A total of 15.3% of the participants were bitten by ticks in the days or months before the date of sampling. We detected anti-CCHFV IgG antibodies with two diagnostic assays in three of the 516 individuals and with one diagnostic assay in six of the 516 individuals.

Conclusion

Seroprevalence of CCHFV was between 0.58% and 1.16% in Castile-León, Spain. This is the first study in western Spain that showed circulation of CCHFV in healthy people.

© Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Loading

Article metrics loading...

/content/10.2807/1560-7917.ES.2020.25.10.1900507
2020-03-12
2024-12-03
http://instance.metastore.ingenta.com/content/10.2807/1560-7917.ES.2020.25.10.1900507
Loading
Loading full text...

Full text loading...

/deliver/fulltext/eurosurveillance/25/10/eurosurv-25-10-5.html?itemId=/content/10.2807/1560-7917.ES.2020.25.10.1900507&mimeType=html&fmt=ahah

References

  1. Ballinger MJ, Medeiros AS, Qin J, Taylor DJ. Unexpected differences in the population genetics of phasmavirids (Bunyavirales) from subarctic ponds. Virus Evol. 2017;3(1):vex015.  https://doi.org/10.1093/ve/vex015  PMID: 28744370 
  2. Leblebicioglu H, Eroglu C, Erciyas-Yavuz K, Hokelek M, Acici M, Yilmaz H. Role of migratory birds in spreading Crimean-Congo hemorrhagic fever, Turkey. Emerg Infect Dis. 2014;20(8):1331-4.  https://doi.org/10.3201/eid2008.131547  PMID: 25062428 
  3. Spengler JR, Bente DA. Crimean-Congo hemorrhagic fever in Spain - New arrival or silent resident? N Engl J Med. 2017;377(2):106-8.  https://doi.org/10.1056/NEJMp1707436  PMID: 28700846 
  4. Estrada-Peña A, de la Fuente J. The ecology of ticks and epidemiology of tick-borne viral diseases. Antiviral Res. 2014;108:104-28.  https://doi.org/10.1016/j.antiviral.2014.05.016  PMID: 24925264 
  5. Bente DA, Forrester NL, Watts DM, McAuley AJ, Whitehouse CA, Bray M. Crimean-Congo hemorrhagic fever: history, epidemiology, pathogenesis, clinical syndrome and genetic diversity. Antiviral Res. 2013;100(1):159-89.  https://doi.org/10.1016/j.antiviral.2013.07.006  PMID: 23906741 
  6. Aslam S, Latif MS, Daud M, Rahman ZU, Tabassum B, Riaz MS, et al. Crimean-Congo hemorrhagic fever: Risk factors and control measures for the infection abatement. Biomed Rep. 2016;4(1):15-20.  https://doi.org/10.3892/br.2015.545  PMID: 26870327 
  7. Kasi KK, Sas MA, Sauter-Louis C, Gethmann JM, Groschup MH, Conraths FJ. Risk factors for Crimean-Congo hemorrhagic fever virus infection in Livestock in Pakistan. Int J Infect Dis. 2019;79:137.  https://doi.org/10.1016/j.ijid.2018.11.335 
  8. Sidira P, Maltezou HCC, Haidich A-BA-B, Papa A. Seroepidemiological study of Crimean-Congo haemorrhagic fever in Greece, 2009-2010. Clin Microbiol Infect. 2012;18(2):E16-9.  https://doi.org/10.1111/j.1469-0691.2011.03718.x  PMID: 22192082 
  9. World Health Organization (WHO). 2017 Annual review of diseases prioritized under the Research and Development Blueprint. Meeting report. Geneva, Switzerland: Informal consultation 24-25 Jan 2017. Available from: https://www.who.int/blueprint/what/research-development/2017-Prioritization-Long-Report.pdf?ua=1
  10. World Health Organization (WHO). An R&D Blueprint for Action to Prevent Epidemics: Plan of Action. Geneva: WHO; 2016. Available from: https://www.who.int/blueprint/about/r_d_blueprint_plan_of_action.pdf
  11. World Health Organization (WHO). Blueprint for R&D preparedness and response to public health emergencies due to highly infectious pathogens. Funding & coordination models for preparedness and response. Geneva: WHO; 2016. Available from: https://www.who.int/blueprint/what/improving-coordination/workstream_5_document_on_financing.pdf
  12. Gunes T, Engin A, Poyraz O, Elaldi N, Kaya S, Dokmetas I, et al. Crimean-Congo hemorrhagic fever virus in high-risk population, Turkey. Emerg Infect Dis. 2009;15(3):461-4.  https://doi.org/10.3201/eid1503.080687  PMID: 19239765 
  13. Midilli K, Gargili A, Ergonul O, Sengöz G, Ozturk R, Bakar M, et al. Imported Crimean-Congo hemorrhagic fever cases in Istanbul. BMC Infect Dis. 2007;7(1):54.  https://doi.org/10.1186/1471-2334-7-54  PMID: 17553137 
  14. Eurosurveillance editorial team. Increase in cases of Crimean-Congo haemorrhagic fever, Turkey, 2006. Euro Surveill. 2006;11(7):E060720.2.  PMID: 16966763 
  15. Papa A, Maltezou HC, Tsiodras S, Dalla VG, Papadimitriou T, Pierroutsakos I, et al. A case of Crimean-Congo haemorrhagic fever in Greece, June 2008. Euro Surveill. 2008;13(33):18952.  https://doi.org/10.2807/ese.13.33.18952-en  PMID: 18761893 
  16. Christova I, Younan R, Taseva E, Gladnishka T, Trifonova I, Ivanova V, et al. Hemorrhagic fever with renal syndrome and Crimean-Congo hemorrhagic fever as causes of acute undifferentiated febrile illness in Bulgaria. Vector Borne Zoonotic Dis. 2013;13(3):188-92.  https://doi.org/10.1089/vbz.2011.0938  PMID: 23421884 
  17. Roth C. Outbreak of Crimean-Congo haemorrhagic fever in Kosovo – update. Euro Surveill. 2001;5(25):1731.  https://doi.org/10.2807/esw.05.25.01731-en 
  18. Papa A, Bino S, Llagami A, Brahimaj B, Papadimitriou E, Pavlidou V, et al. Crimean-Congo hemorrhagic fever in Albania, 2001. Eur J Clin Microbiol Infect Dis. 2002;21(8):603-6.  https://doi.org/10.1007/s10096-002-0770-9  PMID: 12226691 
  19. Dreshaj S, Ahmeti S, Ramadani N, Dreshaj G, Humolli I, Dedushaj I. Current situation of Crimean-Congo hemorrhagic fever in Southeastern Europe and neighboring countries: a public health risk for the European Union? Travel Med Infect Dis. 2016;14(2):81-91.  https://doi.org/10.1016/j.tmaid.2016.03.012  PMID: 27044611 
  20. Tall A, Sall AA, Faye O, Diatta B, Sylla R, Faye J, et al. [Two cases of Crimean-Congo haemorrhagic fever (CCHF) in two tourists in Senegal in 2004]. Bull Soc Pathol Exot. 2009;102(3):159-61. PMID: 19739410 
  21. Jauréguiberry S, Tattevin P, Tarantola A, Legay F, Tall A, Nabeth P, et al. Imported Crimean-Congo hemorrhagic fever. J Clin Microbiol. 2005;43(9):4905-7.  https://doi.org/10.1128/JCM.43.9.4905-4907.2005  PMID: 16145173 
  22. Barr DA, Aitken C, Bell DJ, Brown CS, Cropley I, Dawood N, et al. First confirmed case of Crimean-Congo haemorrhagic fever in the UK. Lancet. 2013;382(9902):1458.  https://doi.org/10.1016/S0140-6736(13)61718-3  PMID: 24243135 
  23. Filipe AR, Calisher CH, Lazuick J. Antibodies to Congo-Crimean haemorrhagic fever, Dhori, Thogoto and Bhanja viruses in southern Portugal. Acta Virol. 1985;29(4):324-8. PMID: 2864836 
  24. Estrada-Peña A, Palomar AM, Santibáñez P, Sánchez N, Habela MA, Portillo A, et al. Crimean-Congo hemorrhagic fever virus in ticks, Southwestern Europe, 2010. Emerg Infect Dis. 2012;18(1):179-80.  https://doi.org/10.3201/eid1801.111040  PMID: 22261502 
  25. Negredo A, de la Calle-Prieto F, Palencia-Herrejón E, Mora-Rillo M, Astray-Mochales J, Sánchez-Seco MP, et al. Autochthonous Crimean-Congo hemorrhagic fever in Spain. N Engl J Med. 2017;377(2):154-61.  https://doi.org/10.1056/NEJMoa1615162  PMID: 28700843 
  26. Cajimat MNB, Rodriguez SE, Schuster IUE, Swetnam DM, Ksiazek TG, Habela MA, et al. Genomic characterization of Crimean-Congo hemorrhagic fever virus in hyalomma tick from Spain, 2014. Vector Borne Zoonotic Dis. 2017;17(10):714-9.  https://doi.org/10.1089/vbz.2017.2190  PMID: 28836897 
  27. Sierra MJ, García San Miguel L, García M, Vila B, Suárez B, Monge S, et al. Informe de situación y evaluación del riesgo de transmisión de Fiebre Hemorrágica de Crimea-Congo (FHCC) en España. [Status report and risk assessment of transmission of Crimean-Congo haemorrhagic fever (CCHF) in Spain]. Madrid: Centro de Coordinación de Alertas y Emergencias Sanitarias, Ministerio de Sanidad, Consumo y Bienestar Social; 2019. Spanish. Available from: https://www.mscbs.gob.es/profesionales/saludPublica/ccayes/analisisituacion/doc/ER_FHCC.pdf
  28. Negredo A, Habela MÁ, Ramírez de Arellano E, Diez F, Lasala F, López P, et al. Survey of Crimean-Congo hemorrhagic fever enzootic focus, Spain, 2011-2015. Emerg Infect Dis. 2019;25(6):1177-84.  https://doi.org/10.3201/eid2506.180877  PMID: 31107219 
  29. Spengler JR, Estrada-Peña A. Host preferences support the prominent role of Hyalomma ticks in the ecology of Crimean-Congo hemorrhagic fever. PLoS Negl Trop Dis. 2018;12(2):e0006248.  https://doi.org/10.1371/journal.pntd.0006248  PMID: 29420542 
  30. Palomar AM, Portillo A, Santibáñez S, García-Álvarez L, Muñoz-Sanz A, Márquez FJ, et al. Molecular (ticks) and serological (humans) study of Crimean-Congo hemorrhagic fever virus in the Iberian Peninsula, 2013-2015. Enferm Infecc Microbiol Clin. 2017;35(6):344-7.  https://doi.org/10.1016/j.eimc.2017.01.009  PMID: 28291670 
  31. National Statistics Institute (INE). España en cifras 2019. Población. [Spain in numbers. Population]. Madrid: INE; 2019. Spanish. Available from: https://www.ine.es/prodyser/espa_cifras/2019/10/#zoom=z
  32. Dowall SD, Richards KS, Graham VA, Chamberlain J, Hewson R. Development of an indirect ELISA method for the parallel measurement of IgG and IgM antibodies against Crimean-Congo haemorrhagic fever (CCHF) virus using recombinant nucleoprotein as antigen. J Virol Methods. 2012;179(2):335-41.  https://doi.org/10.1016/j.jviromet.2011.11.020  PMID: 22155577 
  33. Tezer H, Polat M. Diagnosis of Crimean-Congo hemorrhagic fever. Expert Rev Anti Infect Ther. 2015;13(5):555-66.  https://doi.org/10.1586/14787210.2015.1021782  PMID: 25746112 
  34. Burt FJ. Laboratory diagnosis of Crimean-Congo hemorrhagic fever virus infections. Future Virol. 2011;6(7):831-41.  https://doi.org/10.2217/fvl.11.47 
  35. Németh V, Oldal M, Egyed L, Gyuranecz M, Erdélyi K, Kvell K, et al. Serologic evidence of Crimean-Congo hemorrhagic fever virus infection in Hungary. Vector Borne Zoonotic Dis. 2013;13(4):270-2.  https://doi.org/10.1089/vbz.2012.1011  PMID: 23421895 
  36. Papa A, Dalla V, Papadimitriou E, Kartalis GNN, Antoniadis A. Emergence of Crimean-Congo haemorrhagic fever in Greece. Clin Microbiol Infect. 2010;16(7):843-7.  https://doi.org/10.1111/j.1469-0691.2009.02996.x  PMID: 19845692 
  37. Vanhomwegen J, Alves MJ, Zupanc TA, Bino S, Chinikar S, Karlberg H, et al. Diagnostic assays for Crimean-Congo hemorrhagic fever. Emerg Infect Dis. 2012;18(12):1958-65.  https://doi.org/10.3201/eid1812.120710  PMID: 23171700 
  38. de Ory F, Guisasola M-E, Balfagón P, Sanz JC. Comparison of commercial methods of immunoblot, ELISA, and chemiluminescent immunoassay for detecting type-specific herpes simplex viruses-1 and -2 IgG. J Clin Lab Anal. 2018;32(1):e22203.  https://doi.org/10.1002/jcla.22203  PMID: 28332725 
  39. Stramer SL, Hollinger FB, Katz LM, Kleinman S, Metzel PS, Gregory KR, et al. Emerging infectious disease agents and their potential threat to transfusion safety. Transfusion. 2009;49(Suppl 2):1S-29S.  https://doi.org/10.1111/j.1537-2995.2009.02279.x  PMID: 19686562 
  40. European Centre for Disease Control and Prevention ECDC). Rapid risk assessment: Crimean–Congo haemorrhagic fever in Spain. Stockholm: ECDC; 2016. Available from: https://www.ecdc.europa.eu/en/publications-data/rapid-risk-assessment-crimean-congo-haemorrhagic-fever-spain-9-september-2016
  41. Mertens M, Schmidt K, Ozkul A, Groschup MH. The impact of Crimean-Congo hemorrhagic fever virus on public health. Antiviral Res. 2013;98(2):248-60.  https://doi.org/10.1016/j.antiviral.2013.02.007  PMID: 23458713 
  42. López-Vélez R, Molina Moreno R. [Climate change in spain and risk of infectious and parasitic diseases transmitted by arthropods and rodents]. Rev Esp Salud Publica. 2005;79(2):177-90.  PMID: 15913053 
  43. Brady OJ, Gething PW, Bhatt S, Messina JP, Brownstein JS, Hoen AG, et al. Refining the global spatial limits of dengue virus transmission by evidence-based consensus. PLoS Negl Trop Dis. 2012;6(8):e1760.  https://doi.org/10.1371/journal.pntd.0001760  PMID: 22880140 
  44. Yactayo S, Staples JE, Millot V, Cibrelus L, Ramon-Pardo P. Epidemiology of chikungunya in the Americas. J Infect Dis. 2016;214(suppl 5):S441-5.  https://doi.org/10.1093/infdis/jiw390  PMID: 27920170 
  45. de La Rocque S, Balenghien T, Halos L, Dietze K, Claes F, Ferrari G, et al. A review of trends in the distribution of vector-borne diseases: is international trade contributing to their spread? Rev Sci Tech. 2011;30(1):119-30.  https://doi.org/10.20506/rst.30.1.2018  PMID: 21809758 
  46. Kilpatrick AM, Randolph SE. Drivers, dynamics, and control of emerging vector-borne zoonotic diseases. Lancet. 2012;380(9857):1946-55.  https://doi.org/10.1016/S0140-6736(12)61151-9  PMID: 23200503 
Crimean-Congo haemorrhagic fever (CCHF) virus-specific antibody detection in blood donors, Castile-León, Spain, summer 2017 and 2018
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=L%C3%ADa+Monsalve+Arteaga&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Monsalve Arteaga Lía</a>, <a href="/search?value1=Juan+Luis+Mu%C3%B1oz+Bellido&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Muñoz Bellido Juan Luis</a>, <a href="/search?value1=Mar%C3%ADa+Carmen+Vieira+Lista&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Vieira Lista María Carmen</a>, <a href="/search?value1=Mar%C3%ADa+Bel%C3%A9n++Vicente+Santiago&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Vicente Santiago María Belén </a>, <a href="/search?value1=Pedro+Fern%C3%A1ndez+Soto&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Fernández Soto Pedro</a>, <a href="/search?value1=Isabel+Bas&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Bas Isabel</a>, <a href="/search?value1=Nuria+Leralta&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Leralta Nuria</a>, <a href="/search?value1=Fernando+de+Ory+Manch%C3%B3n&option1=author&noRedirect=true" class="nonDisambigAuthorLink">de Ory Manchón Fernando</a>, <a href="/search?value1=Ana+Isabel+Negredo&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Negredo Ana Isabel</a>, <a href="/search?value1=Mar%C3%ADa+Paz+S%C3%A1nchez+Seco&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Sánchez Seco María Paz</a>, <a href="/search?value1=Montserrat+Alonso+Sard%C3%B3n&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Alonso Sardón Montserrat</a>, <a href="/search?value1=Sonia+P%C3%A9rez+Gonz%C3%A1lez&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Pérez González Sonia</a>, <a href="/search?value1=Ana+Jim%C3%A9nez+del+Bianco&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Jiménez del Bianco Ana</a>, <a href="/search?value1=Lydia+Blanco+Peris&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Blanco Peris Lydia</a>, <a href="/search?value1=Rufino+Alamo-Sanz&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Alamo-Sanz Rufino</a>, <a href="/search?value1=Roger+Hewson&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Hewson Roger</a>, <a href="/search?value1=Moncef+Belhassen-Garc%C3%ADa&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Belhassen-García Moncef</a>, <a href="/search?value1=Antonio+Muro&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Muro Antonio</a></span>. Crimean-Congo haemorrhagic fever (CCHF) virus-specific antibody detection in blood donors, Castile-León, Spain, summer 2017 and 2018. <a href="/content/ecdc">Euro Surveill.</a> 2020;25(10):pii=1900507. <a href="https://doi.org/10.2807/1560-7917.ES.2020.25.10.1900507" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2020.25.10.1900507</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 05 Aug 2019;&nbsp;&nbsp; <span class="generated">Accepted</span>: 07 Dec 2019 </span> </p>
/content/10.2807/1560-7917.ES.2020.25.10.1900507
/content/10.2807/1560-7917.ES.2020.25.10.1900507
Loading

Data & Media loading...

Submit comment
Close
Comment moderation successfully completed
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error