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Abstract

Introduction: Since 2015, increased migration from Asia and Africa to Europe has raised public health concerns about potential importation of extended-spectrum β-lactamase-producing Enterobacteriaceae (ESBL-PE), specifically those producing carbapenemases (C-PE), into European hospitals.

Aims: To inform infection control practices about ESBL-PE prevalence in asylum seekers and to investigate whether C-PE prevalence exceeds that in the German population.

Methods: Cross-sectional study from April 2016–March 2017. Routinely collected stool samples from asylum seekers were tested for antibiotic resistant Enterobacteriaceae. Country/region of origin and demographic characteristics were explored as risk factors for faecal colonisation.

Results: Of 1,544 individuals, 294 tested positive for ESBL-PE colonisation (19.0%; 95% confidence intervals (CI): 17.0–21.0). Asylum seekers originating from Afghanistan/Pakistan/Iran had a prevalence of 29.3% (95% CI: 25.6–33.2), from Syria 20.4% (95% CI: 16.1–25.2) and from Eritrea/Somalia 11.9% (95% CI: 8.7–15.7). CTX-M-15 (79%) and CTX-M-27 (10%) were the most common ESBL determinants. Highest ESBL-PE prevalences were observed in boys under 10 years and women aged 20–39 years (interaction: p = 0.03). No individuals tested positive for C-PE. Faecal C-PE colonisation prevalence in asylum seekers was not statistically significantly different from prevalence reported in German communities.

Conclusion: In absence of other risk factors, being a newly arrived asylum seeker from a region with increased faecal ESBL-PE colonisation prevalence is not an indicator for C-PE colonisation and thus not a reason for pre-emptive screening and isolation upon hospital admission.

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2019-02-21
2024-11-21
http://instance.metastore.ingenta.com/content/10.2807/1560-7917.ES.2019.24.8.1800030
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No evidence of carbapenemase-producing Enterobacteriaceae in stool samples of 1,544 asylum seekers arriving in Rhineland-Palatinate, Germany, April 2016 to March, 2017
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=Lutz+Ehlkes&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Ehlkes Lutz</a>, <a href="/search?value1=Yvonne+Pfeifer&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Pfeifer Yvonne</a>, <a href="/search?value1=Guido+Werner&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Werner Guido</a>, <a href="/search?value1=Ralf+Ignatius&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Ignatius Ralf</a>, <a href="/search?value1=Manfred+Vogt&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Vogt Manfred</a>, <a href="/search?value1=Tim+Eckmanns&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Eckmanns Tim</a>, <a href="/search?value1=Philipp+Zanger&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Zanger Philipp</a>, <a href="/search?value1=Jan+Walter&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Walter Jan</a></span>. No evidence of carbapenemase-producing Enterobacteriaceae in stool samples of 1,544 asylum seekers arriving in Rhineland-Palatinate, Germany, April 2016 to March, 2017. <a href="/content/ecdc">Euro Surveill.</a> 2019;24(8):pii=1800030. <a href="https://doi.org/10.2807/1560-7917.ES.2019.24.8.1800030" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2019.24.8.1800030</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 19 Jan 2018;&nbsp;&nbsp; <span class="generated">Accepted</span>: 30 Aug 2018 </span> </p>
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