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Multidisciplinary, evidence-based consensus guidelines for human papillomavirus (HPV) vaccination in high-risk populations, Spain, 2016
- Xavier Martínez-Gómez1 , Adrian Curran2 , Magda Campins1 , Laia Alemany3 , José Ángel Rodrigo-Pendás1 , Natalia Borruel4 , Xavier Castellsagué3 , Cristina Díaz-de-Heredia5 , Fernando A Moraga-Llop6 , Marta del Pino7,8 , Aureli Torné7,8
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View Affiliations Hide AffiliationsAffiliations: 1 Servei de Medicina Preventiva i Epidemiologia, Hospital Universitari Vall d’Hebron – Universitat Autònoma de Barcelona, Barcelona, España 2 Servei de Malalties Infeccioses, Hospital Universitari Vall d’Hebron – Universitat Autònoma de Barcelona, Barcelona, España 3 Programa de Recerca en Epidemiologia del Càncer, Institut Català d’Oncologia – IDIBELL CIBER Epidemiología y Salud Pública, Barcelona, España 4 Unitat d'Atenció Crohn-Colitis, Servei d’Aparell Digestiu; Hospital Universitari Vall d’Hebron – Universitat Autònoma de Barcelona, Barcelona, España 5 Servei d’Oncologia i Hematologia Pediàtrica, Hospital Universitari Vall d’Hebron - Universitat Autònoma de Barcelona, Barcelona, España 6 Asociación Española de Vacunología, Barcelona, España 7 Unidad de Ginecología Oncológica, Instituto Clínico de Ginecología y Obstetricia y Neonatología (ICGON), Hospital Clínic de Barcelona, Barcelona, España 8 Instituto de Investigaciones Biomédicas August Pi i Sunyer (IDIBAPS), Facultad de Medicina, Universidad de Barcelona, Barcelona, EspañaMagda Campinsmcampins vhebron.net
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Citation style for this article: Martínez-Gómez Xavier, Curran Adrian, Campins Magda, Alemany Laia, Rodrigo-Pendás José Ángel, Borruel Natalia, Castellsagué Xavier, Díaz-de-Heredia Cristina, Moraga-Llop Fernando A, del Pino Marta, Torné Aureli. Multidisciplinary, evidence-based consensus guidelines for human papillomavirus (HPV) vaccination in high-risk populations, Spain, 2016. Euro Surveill. 2019;24(7):pii=1700857. https://doi.org/10.2807/1560-7917.ES.2019.24.7.1700857 Received: 22 Dec 2017; Accepted: 15 Oct 2018
Abstract
Introduction: Although human papillomavirus (HPV) routine vaccination programmes have been implemented around the world and recommendations have been expanded to include other high-risk individuals, current recommendations often differ between countries in Europe, as well as worldwide.
Aim: To find and summarise the best available evidence of HPV vaccination in high-risk patients aiding clinicians and public health workers in the day-to-day vaccine decisions relating to HPV in Spain.
Methods: We conducted a systematic review of the immunogenicity, safety and efficacy/effectiveness of HPV vaccination in high-risk populations between January 2006 and June 2016. HPV vaccination recommendations were established with levels of evidence according to the Grading of Recommendations Assessment, Development and Evaluation (GRADE) system.
Results: A strong recommendation about HPV vaccination was made in the following groups: HIV infected patients aged 9–26 years; men who have sex with men aged 9–26 years; women with precancerous cervical lesions; patients with congenital bone marrow failure syndrome; women who have received a solid organ transplant or hematopoietic stem cell transplantation aged 9–26 years; and patients diagnosed with recurrent respiratory papillomatosis.
Conclusions: Data concerning non-routine HPV vaccination in populations with a high risk of HPV infection and associated lesions were scarce. We have developed a document to evaluate and establish evidence-based guidelines on HPV vaccination in high-risk populations in Spain, based on best available scientific evidence.
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