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Abstract

The ‘Finnish new variant of ’ (FI-nvCT), escaping detection in the Aptima Combo 2 assay (AC2), is widespread across Norway. From June to August 2019, 84% (81/97) of available AC2/Aptima CT discordant samples from five laboratories were confirmed as FI-nvCT. Two additional CT variants (CT 23S rRNA C1514T and G1523A) also escaped AC2 detection. The high FI-nvCT proportion might indicate a long-term national spread and it cannot be excluded that FI-nvCT emerged in Norway.

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/content/10.2807/1560-7917.ES.2019.24.42.1900592
2019-10-17
2024-11-28
http://instance.metastore.ingenta.com/content/10.2807/1560-7917.ES.2019.24.42.1900592
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References

  1. Rantakokko-Jalava K, Hokynar K, Hieta N, Keskitalo A, Jokela P, Muotiala A, et al. Chlamydia trachomatis samples testing falsely negative in the Aptima Combo 2 test in Finland, 2019. Euro Surveill. 2019;24(22):1900298.  https://doi.org/10.2807/1560-7917.ES.2019.24.22.1900298  PMID: 31164192 
  2. Hokynar K, Rantakokko-Jalava K, Hakanen A, Havana M, Mannonen L, Jokela P, et al. The Finnish New Variant of Chlamydia trachomatis with a Single Nucleotide Polymorphism in the 23S rRNA Target Escapes Detection by the Aptima Combo 2 Test. Microorganisms. 2019;7(8):E227.  https://doi.org/10.3390/microorganisms7080227  PMID: 31370214 
  3. Unemo M, Hansen M, Hadad R, Lindroth Y, Fredlund H, Puolakkainen M, et al. Finnish new variant of Chlamydia trachomatis escaping detection in the Aptima Combo 2 assay also present in Örebro County, Sweden, May 2019. Euro Surveill. 2019;24(26):1900370.  https://doi.org/10.2807/1560-7917.ES.2019.24.26.1900370  PMID: 31266590 
  4. European Centre for Disease Prevention and Control (ECDC). Rapid risk assessment: Chlamydia trachomatis false-negative test results by Aptima Combo 2 CT/NG assay (Hologic) in the EU/EEA. Stockholm: ECDC; 2019 17.06.
  5. Unemo M, Getman D, Hadad R, Cole M, Thomson N, Puolakkainen M, et al. Letter to the editor: Chlamydia trachomatis samples testing falsely negative in the Aptima Combo 2 test in Finland, 2019. Euro Surveill. 2019;24(24):1900354.  https://doi.org/10.2807/1560-7917.ES.2019.24.24.1900354  PMID: 31213219 
  6. Hologic. Package insert Aptima Combo 2 Assay. Available from: https://www.hologic.com/sites/default/files/package-insert/502487-IFU-PI_001_01.pdf
  7. Blystad H, Caugant DA, Klovstad H, Nilsen O, Rykkvin R. Overvåkning av seksuelt overførbare infeksjoner og blodbårne hepatitter. Årsrapport 2018. Oslo: Folkehelseinstituttet; 2019.
  8. Geisler WM. Duration of untreated, uncomplicated Chlamydia trachomatis genital infection and factors associated with chlamydia resolution: a review of human studies. J Infect Dis. 2010;201(Supplement_2) Suppl 2;S104-13.  https://doi.org/10.1086/652402  PMID: 20470048 
  9. Geisler WM, Lensing SY, Press CG, Hook EW 3rd. Spontaneous resolution of genital Chlamydia trachomatis infection in women and protection from reinfection. J Infect Dis. 2013;207(12):1850-6.  https://doi.org/10.1093/infdis/jit094  PMID: 23470847 
  10. Lewis J, Price MJ, Horner PJ, White PJ. Genital Chlamydia trachomatis Infections Clear More Slowly in Men Than Women, but Are Less Likely to Become Established. J Infect Dis. 2017;216(2):237-44.  https://doi.org/10.1093/infdis/jix283  PMID: 28838150 
  11. Roberts DJ, Davis GS, Cole MJ, Naik D, Maru H, Woodford N, et al. On Behalf Of The Incident Management Team. Prevalence of new variants of Chlamydia trachomatis escaping detection by the Aptima Combo 2 assay, England, June to August 2019. Euro Surveill. 2019;24(38):1900557.  https://doi.org/10.2807/1560-7917.ES.2019.24.38.1900557  PMID: 31552817 
  12. Herrmann B, Törner A, Low N, Klint M, Nilsson A, Velicko I, et al. Emergence and spread of Chlamydia trachomatis variant, Sweden. Emerg Infect Dis. 2008;14(9):1462-5.  https://doi.org/10.3201/eid1409.080153  PMID: 18760021 
  13. Unemo M, Clarke IN. The Swedish new variant of Chlamydia trachomatis. Curr Opin Infect Dis. 2011;24(1):62-9.  https://doi.org/10.1097/QCO.0b013e32834204d5  PMID: 21157332 
The ‘Finnish new variant of Chlamydia trachomatis’ escaping detection in the Aptima Combo 2 assay is widespread across Norway, June to August 2019
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=Tone+Bjordal+Johansen&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Johansen Tone Bjordal</a>, <a href="/search?value1=Hilde+Kl%C3%B8vstad&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Kløvstad Hilde</a>, <a href="/search?value1=Rikard+Rykkvin&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Rykkvin Rikard</a>, <a href="/search?value1=Einar+Bredo+Herrfurth-Erichsen&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Herrfurth-Erichsen Einar Bredo</a>, <a href="/search?value1=Joakim+Sorthe&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Sorthe Joakim</a>, <a href="/search?value1=Gro+Nj%C3%B8lstad&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Njølstad Gro</a>, <a href="/search?value1=Marit+Helen+Ebbesen&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Ebbesen Marit Helen</a>, <a href="/search?value1=Randi+Monsen+Nygaard&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Nygaard Randi Monsen</a>, <a href="/search?value1=Ellen+Kristin+Sandmoen&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Sandmoen Ellen Kristin</a>, <a href="/search?value1=Carina+Thilesen&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Thilesen Carina</a>, <a href="/search?value1=Annette+Onken&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Onken Annette</a>, <a href="/search?value1=Inger+Liljedal&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Liljedal Inger</a>, <a href="/search?value1=Ronza+Hadad&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Hadad Ronza</a>, <a href="/search?value1=Magnus+Unemo&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Unemo Magnus</a></span>. The ‘Finnish new variant of Chlamydia trachomatis’ escaping detection in the Aptima Combo 2 assay is widespread across Norway, June to August 2019. <a href="/content/ecdc">Euro Surveill.</a> 2019;24(42):pii=1900592. <a href="https://doi.org/10.2807/1560-7917.ES.2019.24.42.1900592" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2019.24.42.1900592</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 24 Sept 2019;&nbsp;&nbsp; <span class="generated">Accepted</span>: 17 Oct 2019 </span> </p>
/content/10.2807/1560-7917.ES.2019.24.42.1900592
/content/10.2807/1560-7917.ES.2019.24.42.1900592
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