1887
  1. Home
  2. Eurosurveillance
  3. Volume 24, Issue 4, 24/Jan/2019
  4. Article
Rapid communication Open Access
Like 0
Download

Abstract

Using a test-negative design, the Canadian Sentinel Practitioner Surveillance Network assessed interim 2018/19 vaccine effectiveness (VE) against predominant influenza A(H1N1)pdm09 viruses. Adjusted VE was 72% (95% confidence interval: 60 to 81) against medically attended, laboratory-confirmed influenza A(H1N1)pdm09 illness. This substantial vaccine protection was observed in all age groups, notably young children who appeared to be disproportionately affected. Sequence analysis identified heterogeneity in emerging clade 6B.1 viruses but no dominant drift variant.

© Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Loading

Article metrics loading...

/content/10.2807/1560-7917.ES.2019.24.4.1900055
2019-01-24
2024-11-22
http://instance.metastore.ingenta.com/content/10.2807/1560-7917.ES.2019.24.4.1900055
Loading
Loading full text...

Full text loading...

/deliver/fulltext/eurosurveillance/24/4/eurosurv-24-4-2.html?itemId=/content/10.2807/1560-7917.ES.2019.24.4.1900055&mimeType=html&fmt=ahah

References

  1. Public Health Agency of Canada (PHAC). Influenza weekly reports 2018-19 season Ottawa: PHAC. [Accessed: 16 Jan 2019]. Available from: https://www.canada.ca/en/public-health/services/diseases/flu-influenza/influenza-surveillance/weekly-reports-2018-2019-season.html
  2. Skowronski DM, Chambers C, De Serres G, Dickinson JA, Winter AL, Hickman R, et al. Early season co-circulation of influenza A(H3N2) and B(Yamagata): interim estimates of 2017/18 vaccine effectiveness, Canada, January 2018. Euro Surveill. 2018;23(5):18-00035.  https://doi.org/10.2807/1560-7917.ES.2018.23.5.18-00035  PMID: 29409570 
  3. Skowronski D, Chambers C, Sabaiduc S, De Serres G, Dickinson J, Winter A, et al. Interim estimates of 2013/14 vaccine effectiveness against influenza A(H1N1)pdm09 from Canada s sentinel surveillance network, January 2014. Euro Surveill. 2014;19(5):20690.  https://doi.org/10.2807/1560-7917.ES2014.19.5.20690  PMID: 24524234 
  4. Chambers C, Skowronski DM, Sabaiduc S, Winter AL, Dickinson JA, De Serres G, et al. Interim estimates of 2015/16 vaccine effectiveness against influenza A(H1N1)pdm09, Canada, February 2016. Euro Surveill. 2016;21(11):30168.  https://doi.org/10.2807/1560-7917.ES.2016.21.11.30168  PMID: 27020673 
  5. World Health Organization (WHO). WHO recommendations on the composition of influenza virus vaccines Geneva: WHO. [Accessed: 16 Jan 2019]. Available from: https://www.who.int/influenza/vaccines/virus/recommendations/en/
  6. Australian Government. 2018 Influenza Season in Australia: A summary from the National Influenza Surveillance Committee. Information Brief (updated on 16 November 2018). Canberra: Department of Health, Australian Government; 2018. Available from: http://www.health.gov.au/internet/main/publishing.nsf/Content/cda-surveil-ozflu-flucurr.htm/$File/2018-Season-Summary.pdf
  7. European Centre for Disease Prevention and Control (ECDC). Influenza virus characterisation. Summary Europe, November 2018. Stockholm: ECDC; 2018. Available from: https://ecdc.europa.eu/sites/portal/files/documents/ECDCFlu-characterisation-rep-Nov-2018.pdf
  8. Nextstrain. Real-time tracking of influenza A/H1N1pdm evolution 2018. [Accessed: 16 Jan 2019]. Available from: https://nextstrain.org/flu/seasonal/h1n1pdm/ha/3y
  9. Brownlee GG, Fodor E. The predicted antigenicity of the haemagglutinin of the 1918 Spanish influenza pandemic suggests an avian origin. Philos Trans R Soc Lond B Biol Sci. 2001;356(1416):1871-6.  https://doi.org/10.1098/rstb.2001.1001  PMID: 11779386 
  10. Skowronski DM, Chambers C, Sabaiduc S, De Serres G, Winter AL, Dickinson JA, et al. Integrated sentinel surveillance linking genetic, antigenic, and epidemiologic monitoring of influenza vaccine-virus relatedness and effectiveness during the 2013-2014 influenza season. J Infect Dis. 2015;212(5):726-39.  https://doi.org/10.1093/infdis/jiv177  PMID: 25784728 
  11. Lee AJ, Das SR, Wang W, Fitzgerald T, Pickett BE, Aevermann BD, et al. Diversifying selection analysis predicts antigenic evolution of 2009 pandemic H1N1 influenza A virus in humans. J Virol. 2015;89(10):5427-40.  https://doi.org/10.1128/JVI.03636-14  PMID: 25741011 
  12. Belongia EA, Simpson MD, King JP, Sundaram ME, Kelley NS, Osterholm MT, et al. Variable influenza vaccine effectiveness by subtype: a systematic review and meta-analysis of test-negative design studies. Lancet Infect Dis. 2016;16(8):942-51.  https://doi.org/10.1016/S1473-3099(16)00129-8  PMID: 27061888 
  13. Skowronski DM, Chambers C, Sabaiduc S, De Serres G, Winter AL, Dickinson JA, et al. Beyond antigenic match: possible agent-host and immuno-epidemiological influences on influenza vaccine effectiveness during the 2015-2016 season in Canada. J Infect Dis. 2017;216(12):1487-500.  https://doi.org/10.1093/infdis/jix526  PMID: 29029166 
  14. Centers for Disease Control and Prevention (CDC). FluView: Weekly U.S. influenza surveillance report. Atlanta: CDC. [Accessed: 16 Jan 2019]. Available from: https://www.cdc.gov/flu/weekly/
  15. European Centre for Disease Prevention and Control (ECDC). Flu News Europe: Joint ECDC-WHO/Europe weekly influenza update. [Accessed: 16 Jan 2019]. Stockholm: ECDC. Available from: http://flunewseurope.org/
  16. Strengell M, Ikonen N, Ziegler T, Julkunen I. Minor changes in the hemagglutinin of influenza A(H1N1)2009 virus alter its antigenic properties. PLoS One. 2011;6(10):e25848.  https://doi.org/10.1371/journal.pone.0025848  PMID: 22022458 
  17. Li C, Hatta M, Burke DF, Ping J, Zhang Y, Ozawa M, et al. Selection of antigenically advanced variants of seasonal influenza viruses. Nat Microbiol. 2016;1(6):16058.  https://doi.org/10.1038/nmicrobiol.2016.58  PMID: 27572841 
  18. Guarnaccia T, Carolan LA, Maurer-Stroh S, Lee RTC, Job E, Reading PC, et al. Antigenic drift of the pandemic 2009 A(H1N1) influenza virus in A ferret model. PLoS Pathog. 2013;9(5):e1003354.  https://doi.org/10.1371/journal.ppat.1003354  PMID: 23671418 
  19. Statistics Canada. Population estimates on July 1st, by age and sex. Table 17-10-0005-01. Ottawa: Statistics Canada. [Accessed: 16 Jan 2019]. Available from: https://www150.statcan.gc.ca/t1/tbl1/en/tv.action?pid=1710000501
Interim estimates of 2018/19 vaccine effectiveness against influenza A(H1N1)pdm09, Canada, January 2019
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=Danuta+M+Skowronski&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Skowronski Danuta M</a>, <a href="/search?value1=Siobhan+Leir&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Leir Siobhan</a>, <a href="/search?value1=Suzana+Sabaiduc&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Sabaiduc Suzana</a>, <a href="/search?value1=Michelle+Murti&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Murti Michelle</a>, <a href="/search?value1=James+A+Dickinson&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Dickinson James A</a>, <a href="/search?value1=Romy+Olsha&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Olsha Romy</a>, <a href="/search?value1=Jonathan+B+Gubbay&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Gubbay Jonathan B</a>, <a href="/search?value1=Matthew+A+Croxen&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Croxen Matthew A</a>, <a href="/search?value1=Hugues+Charest&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Charest Hugues</a>, <a href="/search?value1=Tracy+Chan&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Chan Tracy</a>, <a href="/search?value1=Nathalie+Bastien&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Bastien Nathalie</a>, <a href="/search?value1=Yan+Li&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Li Yan</a>, <a href="/search?value1=Mel+Krajden&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Krajden Mel</a>, <a href="/search?value1=Gaston+De+Serres&option1=author&noRedirect=true" class="nonDisambigAuthorLink">De Serres Gaston</a></span>. Interim estimates of 2018/19 vaccine effectiveness against influenza A(H1N1)pdm09, Canada, January 2019. <a href="/content/ecdc">Euro Surveill.</a> 2019;24(4):pii=1900055. <a href="https://doi.org/10.2807/1560-7917.ES.2019.24.4.1900055" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2019.24.4.1900055</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 18 Jan 2019;&nbsp;&nbsp; <span class="generated">Accepted</span>: 24 Jan 2019 </span> </p>
/content/10.2807/1560-7917.ES.2019.24.4.1900055
/content/10.2807/1560-7917.ES.2019.24.4.1900055
Loading

Data & Media loading...

Submit comment
Close
Comment moderation successfully completed
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error