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Abstract

Background

is a leading cause of healthcare-associated diarrhoea in middle and high-income countries. Up to 2018, there has been no systematic, annual surveillance for infections (CDI) in France.

Aims

To provide an updated overview of the epidemiology of CDI in France between 2010 and 2017 based on five different data sources.

Methods

This is a descriptive study of retrospective surveillance and alerts data. Incidence of CDI cases was estimated through the CDI incidence survey (2016) and data from the French National Uniform Hospital Discharge Database (PMSI; 2010–16). Testing frequency for CDI was estimated through the CDI incidence survey and point prevalence studies on healthcare-associated infections (HAI; 2012 and 2017). The national early warning response system for HAI (HAI-EWRS, 2012–17) and National Reference Laboratory data (2012–17) were used to follow the number of severe CDI cases and/or outbreaks.

Results

In 2016, CDI incidence in acute care was 3.6 cases per 10,000 patient days (PD). There was a statistically significant increase in CDI incidence between 2010 and 2016 (+ 14% annually) and testing frequency was 47.4 per 10,000 PD. The number of CDI HAI-EWRS notifications decreased between 2015 and 2017 with only a few large outbreaks reported.

Conclusion

The CDI incidence estimate increased from 2010, but remained below the European average of 7 per 10,000 PD in 2014; there were fewer severe cases or clusters reported in France. The consistency between PMSI and laboratory-based estimated CDI incidence could allow for more routine monitoring of CDI incidence.

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2019-08-29
2024-11-23
http://instance.metastore.ingenta.com/content/10.2807/1560-7917.ES.2019.24.35.1800638
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Epidemiology of Clostridioides difficile infections, France, 2010 to 2017
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=M%C3%A9lanie+Colomb-Cotinat&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Colomb-Cotinat Mélanie</a>, <a href="/search?value1=Laetitia+Assouvie&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Assouvie Laetitia</a>, <a href="/search?value1=Julien+Durand&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Durand Julien</a>, <a href="/search?value1=C%C3%B4me+Daniau&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Daniau Côme</a>, <a href="/search?value1=Lucie+Leon&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Leon Lucie</a>, <a href="/search?value1=Sylvie+Maugat&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Maugat Sylvie</a>, <a href="/search?value1=Sophan+Soing-Altrach&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Soing-Altrach Sophan</a>, <a href="/search?value1=C%C3%A9cile+Gateau&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Gateau Cécile</a>, <a href="/search?value1=Jeanne+Couturier&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Couturier Jeanne</a>, <a href="/search?value1=Isabelle+Arnaud&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Arnaud Isabelle</a>, <a href="/search?value1=Pascal+Astagneau&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Astagneau Pascal</a>, <a href="/search?value1=Anne+Berger-Carbonne&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Berger-Carbonne Anne</a>, <a href="/search?value1=Fr%C3%A9d%C3%A9ric+Barbut&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Barbut Frédéric</a></span>. Epidemiology of Clostridioides difficile infections, France, 2010 to 2017. <a href="/content/ecdc">Euro Surveill.</a> 2019;24(35):pii=1800638. <a href="https://doi.org/10.2807/1560-7917.ES.2019.24.35.1800638" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2019.24.35.1800638</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 26 Nov 2018;&nbsp;&nbsp; <span class="generated">Accepted</span>: 06 Jun 2019 </span> </p>
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