1887
Rapid communication Open Access
Like 0

Abstract

We describe clonal shifts in isolates from clinical samples obtained from patients in Denmark from 2015 to the first quarter (Q1) of 2019. During Q1 2019, the vancomycin-variable enterococci (VVE) ST1421-CT1134 became the most dominant clone and has spread to all five regions in Denmark. Among 174 isolates with or vanA/ genes in Q1 2019, 44% belonged to this type.

Loading

Article metrics loading...

/content/10.2807/1560-7917.ES.2019.24.34.1900503
2019-08-22
2024-12-22
/content/10.2807/1560-7917.ES.2019.24.34.1900503
Loading
Loading full text...

Full text loading...

/deliver/fulltext/eurosurveillance/24/34/eurosurv-24-34-1.html?itemId=/content/10.2807/1560-7917.ES.2019.24.34.1900503&mimeType=html&fmt=ahah

References

  1. Sivertsen A, Pedersen T, Larssen KW, Bergh K, Rønning TG, Radtke A, et al. A Silenced vanA Gene Cluster on a Transferable Plasmid Caused an Outbreak of Vancomycin-Variable Enterococci. Antimicrob Agents Chemother. 2016;60(7):4119-27.  https://doi.org/10.1128/AAC.00286-16  PMID: 27139479 
  2. Kohler P, Eshaghi A, Kim HC, Plevneshi A, Green K, Willey BM, et al. , Toronto Invasive Bacterial Diseases Network (TIBDN). Prevalence of vancomycin-variable Enterococcus faecium (VVE) among vanA-positive sterile site isolates and patient factors associated with VVE bacteremia. PLoS One. 2018;13(3):e0193926.  https://doi.org/10.1371/journal.pone.0193926  PMID: 29566004 
  3. Szakacs TA, Kalan L, McConnell MJ, Eshaghi A, Shahinas D, McGeer A, et al. Outbreak of vancomycin-susceptible Enterococcus faecium containing the wild-type vanA gene. J Clin Microbiol. 2014;52(5):1682-6.  https://doi.org/10.1128/JCM.03563-13  PMID: 24523464 
  4. Coburn B, Low DE, Patel SN, Poutanen SM, Shahinas D, Eshaghi A, et al. Vancomycin-variable Enterococcus faecium: in vivo emergence of vancomycin resistance in a vancomycin-susceptible isolate. J Clin Microbiol. 2014;52(5):1766-7.  https://doi.org/10.1128/JCM.03579-13  PMID: 24523476 
  5. Hansen TA, Pedersen MS, Nielsen LG, Ma CMG, Søes LM, Worning P, et al. Emergence of a vancomycin-variable Enterococcus faecium ST1421 strain containing a deletion in vanX. J Antimicrob Chemother. 2018;73(11):2936-40.  https://doi.org/10.1093/jac/dky308  PMID: 30113682 
  6. Hammerum AM, Baig S, Kamel Y, Roer L, Pinholt M, Gumpert H, et al. Emergence of vanA Enterococcus faecium in Denmark, 2005-15. J Antimicrob Chemother. 2017;72(8):2184-90.  https://doi.org/10.1093/jac/dkx138  PMID: 28541565 
  7. The Danish Integrated Antimicrobial Resistance Monitoring and Research Programme (DANMAP). DANMAP 2017 - Use of antimicrobial agents and occurrence of antimicrobial resistance in bacteria from food animals, food and humans in Denmark. Copenhagen: DANMAP; 2017. Available from: https://www.danmap.org/-/media/arkiv/projekt-sites/danmap/danmap-reports/danmap-2017/danmap2017.pdf?la=en.
  8. de Been M, Pinholt M, Top J, Bletz S, Mellmann A, van Schaik W, et al. Core Genome Multilocus Sequence Typing Scheme for High- Resolution Typing of Enterococcus faecium. J Clin Microbiol. 2015;53(12):3788-97.  https://doi.org/10.1128/JCM.01946-15  PMID: 26400782 
  9. Pinholt M, Bayliss SC, Gumpert H, Worning P, Jensen VVS, Pedersen M, et al. WGS of 1058 Enterococcus faecium from Copenhagen, Denmark, reveals rapid clonal expansion of vancomycin-resistant clone ST80 combined with widespread dissemination of a vanA-containing plasmid and acquisition of a heterogeneous accessory genome. J Antimicrob Chemother. 2019;74(7):1776-85.  https://doi.org/10.1093/jac/dkz118  PMID: 30929020 
  10. van Hal SJ, Beukers AG, Timms VJ, Ellem JA, Taylor P, Maley MW, et al. Relentless spread and adaptation of non-typeable vanA vancomycin-resistant Enterococcus faecium: a genome-wide investigation. J Antimicrob Chemother. 2018;73(6):1487-91.  https://doi.org/10.1093/jac/dky074  PMID: 29566173 
/content/10.2807/1560-7917.ES.2019.24.34.1900503
Loading

Data & Media loading...

Submit comment
Close
Comment moderation successfully completed
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error