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Abstract

Background

Progress towards HIV, hepatitis B virus (HBV) and hepatitis C virus (HCV) elimination requires local prevalence estimates and linkage to care (LTC) of undiagnosed or disengaged cases.

Aim

We aimed to estimate seroprevalence, factors associated with positive blood-borne virus (BBV) serology and numbers needed to screen (NNS) to detect a new BBV diagnosis and achieve full LTC from emergency department (ED) BBV testing.

Methods

During a 9-month programme in an ED in east London, England, testing was offered to adult attendees having a full blood count (FBC). We estimated factors associated with positive BBV serology using logistic regression and NNS as the inverse of seroprevalence. Estimates were weighted to the age, sex and ethnicity of the FBC population.

Results

Of 6,211 FBC patients tested, 217 (3.5%) were positive for at least one BBV. Weighted BBV seroprevalence was 4.2% (95% confidence interval (CI): 3.6–4.9). Adjusted odds ratios (aOR) of positive BBV serology were elevated among patients that were: male (aOR: 2.7; 95% CI: 1.9–3.9), 40–59 years old (aOR: 1.9; 95% CI: 1.4–2.7), of Black British/Black other ethnicity (aOR: 1.8; 95% CI: 1.2–2.8) or had no fixed address (aOR: 2.9; 95% CI: 1.5–5.5). NNS to detect a new BBV diagnosis was 154 (95% CI: 103–233) and 135 (95% CI: 93–200) to achieve LTC.

Conclusions

The low NNS suggests routine BBV screening in EDs may be worthwhile. Those considering similar programmes should use our findings to inform their assessments of anticipated public health benefits.

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This work is licensed under a Creative Commons Attribution 4.0 International License.
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/content/10.2807/1560-7917.ES.2019.24.27.1800377
2019-07-04
2024-11-24
http://instance.metastore.ingenta.com/content/10.2807/1560-7917.ES.2019.24.27.1800377
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Seroprevalence and demographic factors associated with hepatitis B, hepatitis C and HIV infection from a hospital emergency department testing programme, London, United Kingdom, 2015 to 2016
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=Nick+Bundle&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Bundle Nick</a>, <a href="/search?value1=Sooria+Balasegaram&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Balasegaram Sooria</a>, <a href="/search?value1=Sarah+Parry&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Parry Sarah</a>, <a href="/search?value1=Sadna+Ullah&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Ullah Sadna</a>, <a href="/search?value1=Ross+J+Harris&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Harris Ross J</a>, <a href="/search?value1=Karim+Ahmad&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Ahmad Karim</a>, <a href="/search?value1=Graham+R+Foster&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Foster Graham R</a>, <a href="/search?value1=Cheuk+YW+Tong&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Tong Cheuk YW</a>, <a href="/search?value1=Chloe+Orkin&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Orkin Chloe</a></span>. Seroprevalence and demographic factors associated with hepatitis B, hepatitis C and HIV infection from a hospital emergency department testing programme, London, United Kingdom, 2015 to 2016. <a href="/content/ecdc">Euro Surveill.</a> 2019;24(27):pii=1800377. <a href="https://doi.org/10.2807/1560-7917.ES.2019.24.27.1800377" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2019.24.27.1800377</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 07 Jul 2018;&nbsp;&nbsp; <span class="generated">Accepted</span>: 15 May 2019 </span> </p>
/content/10.2807/1560-7917.ES.2019.24.27.1800377
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