1887
Rapid communication Open Access
Like 0

Abstract

We identified the first two cases of the Finnish new variant of (F-nvCT) beyond Finland in two clinical urogenital specimens in Örebro County, Sweden. These Aptima Combo 2 assay-negative specimens were Aptima (CT) assay positive and had the characteristic C1515T mutation in the 23S rRNA gene. From 22 March to 31 May 2019, 1.3% (2/158) of the CT-positive cases in Örebro County were missed because of the F-nvCT. International awareness, investigations and actions are essential.

Loading

Article metrics loading...

/content/10.2807/1560-7917.ES.2019.24.26.1900370
2019-06-27
2024-11-05
http://instance.metastore.ingenta.com/content/10.2807/1560-7917.ES.2019.24.26.1900370
Loading
Loading full text...

Full text loading...

/deliver/fulltext/eurosurveillance/24/26/eurosurv-24-26-3.html?itemId=/content/10.2807/1560-7917.ES.2019.24.26.1900370&mimeType=html&fmt=ahah

References

  1. Rantakokko-Jalava K, Hokynar K, Hieta N, Keskitalo A, Jokela P, Muotiala A, et al. Chlamydia trachomatis samples testing falsely negative in the Aptima Combo 2 test in Finland, 2019. Euro Surveill. 2019;24(22):1900298.  https://doi.org/10.2807/1560-7917.ES.2019.24.22.1900298  PMID: 31164192 
  2. Unemo M, Getman D, Hadad R, Cole M, Thomson N, Puolakkainen M, et al. Letter to the editor: Chlamydia trachomatis samples testing falsely negative in the Aptima Combo 2 test in Finland, 2019. Euro Surveill. 2019;24(24):1900354.  https://doi.org/10.2807/1560-7917.ES.2019.24.24.1900354  PMID: 31213219 
  3. Lanjouw E, Ouburg S, de Vries HJ, Stary A, Radcliffe K, Unemo M. 2015 European guideline on the management of Chlamydia trachomatis infections. Int J STD AIDS. 2016;27(5):333-48.  https://doi.org/10.1177/0956462415618837  PMID: 26608577 
  4. Hologic Inc. Urgent Field Safety Notice (FSN) Aptima Combo 2 Assay (for European Distribution). Brussels: Hologic Inc.; June 2019. Available from: https://mhra.filecamp.com/public/file/3ql3-occ8agbc
  5. Hadfield J, Harris SR, Seth-Smith HMB, Parmar S, Andersson P, Giffard PM, et al. Comprehensive global genome dynamics of Chlamydia trachomatis show ancient diversification followed by contemporary mixing and recent lineage expansion. Genome Res. 2017;27(7):1220-9.  https://doi.org/10.1101/gr.212647.116  PMID: 28588068 
  6. Ripa T, Nilsson P. A variant of Chlamydia trachomatis with deletion in cryptic plasmid: implications for use of PCR diagnostic tests. Euro Surveill. 2006;11(11):E061109.2. PMID: 17213548 
  7. Unemo M, Seth-Smith HM, Cutcliffe LT, Skilton RJ, Barlow D, Goulding D, et al. The Swedish new variant of Chlamydia trachomatis: genome sequence, morphology, cell tropism and phenotypic characterization. Microbiology. 2010;156(Pt 5):1394-404.  https://doi.org/10.1099/mic.0.036830-0  PMID: 20093289 
  8. Herrmann B, Törner A, Low N, Klint M, Nilsson A, Velicko I, et al. Emergence and spread of Chlamydia trachomatis variant, Sweden. Emerg Infect Dis. 2008;14(9):1462-5.  https://doi.org/10.3201/eid1409.080153  PMID: 18760021 
  9. Unemo M, Clarke IN. The Swedish new variant of Chlamydia trachomatis. Curr Opin Infect Dis. 2011;24(1):62-9.  https://doi.org/10.1097/QCO.0b013e32834204d5  PMID: 21157332 
  10. Ison CA, Golparian D, Saunders P, Chisholm S, Unemo M. Evolution of Neisseria gonorrhoeae is a continuing challenge for molecular detection of gonorrhoea: false negative gonococcal porA mutants are spreading internationally. Sex Transm Infect. 2013;89(3):197-201.  https://doi.org/10.1136/sextrans-2012-050829  PMID: 23241969 
  11. Luijt D, Di Lorenzo C, van Loon AM, Unemo M. Most but not all laboratories can detect the recently emerged Neisseria gonorrhoeae porA mutants - results from the QCMD 2013 N. gonorrhoeae external quality assessment programme. Euro Surveill. 2014;19(8):20711.  https://doi.org/10.2807/1560-7917.ES2014.19.8.20711  PMID: 24602276 
/content/10.2807/1560-7917.ES.2019.24.26.1900370
Loading

Data & Media loading...

Submit comment
Close
Comment moderation successfully completed
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error