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Abstract

Since February 2019, over 160 (CT) cases testing negative or equivocal by Aptima Combo 2 (AC2) but positive by Aptima CT test run with Panther instruments occurred in Finland. The AC2 test targets chlamydial 23S rRNA while the CT test targets 16S rRNA. Sequencing of 10 strains revealed a nucleotide substitution in 23S rRNA. The significance of this for the failure of the AC2 test to detect the variant is not yet known.

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An addendum has been published for this content:
Addendum for Euro Surveill. 2019;24(22)
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/content/10.2807/1560-7917.ES.2019.24.22.1900298
2019-05-30
2024-12-26
/content/10.2807/1560-7917.ES.2019.24.22.1900298
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Chlamydia trachomatis samples testing falsely negative in the Aptima Combo 2 test in Finland, 2019
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=Kaisu+Rantakokko-Jalava&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Rantakokko-Jalava Kaisu</a>, <a href="/search?value1=Kati+Hokynar&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Hokynar Kati</a>, <a href="/search?value1=Niina+Hieta&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Hieta Niina</a>, <a href="/search?value1=Anniina+Keskitalo&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Keskitalo Anniina</a>, <a href="/search?value1=Pia+Jokela&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Jokela Pia</a>, <a href="/search?value1=Anna+Muotiala&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Muotiala Anna</a>, <a href="/search?value1=T.+Sakari+Jokiranta&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Jokiranta T. Sakari</a>, <a href="/search?value1=Rutta+Kuusela&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Kuusela Rutta</a>, <a href="/search?value1=Hannu+Sarkkinen&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Sarkkinen Hannu</a>, <a href="/search?value1=Janne+Aittoniemi&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Aittoniemi Janne</a>, <a href="/search?value1=Tytti+Vuorinen&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Vuorinen Tytti</a>, <a href="/search?value1=Antti+J+Hakanen&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Hakanen Antti J</a>, <a href="/search?value1=Mirja+Puolakkainen&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Puolakkainen Mirja</a></span>. Chlamydia trachomatis samples testing falsely negative in the Aptima Combo 2 test in Finland, 2019. <a href="/content/ecdc">Euro Surveill.</a> 2019;24(22):pii=1900298. <a href="https://doi.org/10.2807/1560-7917.ES.2019.24.22.1900298" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2019.24.22.1900298</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 14 May 2019;&nbsp;&nbsp; <span class="generated">Accepted</span>: 30 May 2019 </span> </p>
/content/10.2807/1560-7917.ES.2019.24.22.1900298
/content/10.2807/1560-7917.ES.2019.24.22.1900298
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