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Abstract

In December 2018, a ceftazidime-avibactam (CAZ-AVI)-resistant KPC-2-producing strain was isolated in Finland. CAZ-AVI resistance was observed 34 days after CAZ-AVI treatment in a trauma patient transferred from a hospital in Greece who had been colonised with bla-producing ST39, and later developed a bloodstream infection. The CAZ-AVI-resistant strain contained a novel 15 amino acid insertion in the KPC-2 protein causing structural changes proximal to the KPC-2 active site.

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/content/10.2807/1560-7917.ES.2019.24.19.1900256
2019-05-09
2024-12-27
/content/10.2807/1560-7917.ES.2019.24.19.1900256
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Emergence of ceftazidime-avibactam-resistant Klebsiella pneumoniae during treatment, Finland, December 2018
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=Kati+R%C3%A4is%C3%A4nen&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Räisänen Kati</a>, <a href="/search?value1=Irma+Koivula&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Koivula Irma</a>, <a href="/search?value1=Heikki+Ilmavirta&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Ilmavirta Heikki</a>, <a href="/search?value1=Santeri+Puranen&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Puranen Santeri</a>, <a href="/search?value1=Teemu+Kallonen&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Kallonen Teemu</a>, <a href="/search?value1=Outi+Lyytik%C3%A4inen&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Lyytikäinen Outi</a>, <a href="/search?value1=Jari+Jalava&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Jalava Jari</a></span>. Emergence of ceftazidime-avibactam-resistant Klebsiella pneumoniae during treatment, Finland, December 2018. <a href="/content/ecdc">Euro Surveill.</a> 2019;24(19):pii=1900256. <a href="https://doi.org/10.2807/1560-7917.ES.2019.24.19.1900256" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2019.24.19.1900256</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 24 Apr 2019;&nbsp;&nbsp; <span class="generated">Accepted</span>: 07 May 2019 </span> </p>
/content/10.2807/1560-7917.ES.2019.24.19.1900256
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