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Abstract

Background

A steady increase in HIV drug resistance (HIVDR) has been demonstrated globally in individuals initiating first-line antiretroviral therapy (ART). To support effective use of ART and prevent spread of HIVDR, monitoring is essential.

Aim

We piloted a surveillance system for transmitted HIVDR to assess the feasibility of implementation at the European level.

Method

All 31 countries in the European Union and European Economic Area were invited to retrospectively submit data on individuals newly diagnosed with HIV in 2015 who were tested for antiviral susceptibility before ART, either as case-based or as aggregate data. We used the Stanford HIV database algorithm to translate genetic sequences into levels of drug resistance.

Results

Nine countries participated, with six reporting case-based data on 1,680 individuals and four reporting aggregated data on 1,402 cases. Sequence data were available for 1,417 cases: 14.5% of individuals (n = 244) showed resistance to at least one antiretroviral drug. In case-based surveillance, the highest levels of transmitted HIVDR were observed for non-nucleoside reverse-transcriptase inhibitors (NNRTIs) with resistance detected in 8.6% (n = 145), followed by resistance to nucleoside reverse-transcriptase inhibitors (NRTI) (5.1%; n = 85) and protease inhibitors (2.0%; n = 34).

Conclusion

We conclude that standard reporting of HIVDR data was feasible in the participating countries. Legal barriers for data sharing, consensus on definitions and standardisation of interpretation algorithms should be clarified in the process of enhancing European-wide HIV surveillance with drug resistance information.

© Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
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/content/10.2807/1560-7917.ES.2019.24.19.1800390
2019-05-09
2024-12-26
/content/10.2807/1560-7917.ES.2019.24.19.1800390
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Piloting a surveillance system for HIV drug resistance in the European Union
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=Marita+JW+van+de+Laar&option1=author&noRedirect=true" class="nonDisambigAuthorLink">van de Laar Marita JW</a>, <a href="/search?value1=Arnold+Bosman&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Bosman Arnold</a>, <a href="/search?value1=Anastasia+Pharris&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Pharris Anastasia</a>, <a href="/search?value1=Emmi+Andersson&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Andersson Emmi</a>, <a href="/search?value1=Lambert+Assoumou&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Assoumou Lambert</a>, <a href="/search?value1=Eva+Ay&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Ay Eva</a>, <a href="/search?value1=Norbert+Bannert&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Bannert Norbert</a>, <a href="/search?value1=Barbara+Bartmeyer&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Bartmeyer Barbara</a>, <a href="/search?value1=Melissa+Brady&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Brady Melissa</a>, <a href="/search?value1=Marie-Laure+Chaix&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Chaix Marie-Laure</a>, <a href="/search?value1=Diane+Descamps&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Descamps Diane</a>, <a href="/search?value1=Kenny+Dauwe&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Dauwe Kenny</a>, <a href="/search?value1=Jannik+Fonager&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Fonager Jannik</a>, <a href="/search?value1=Andrea+Hauser&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Hauser Andrea</a>, <a href="/search?value1=Maja+Lunar&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Lunar Maja</a>, <a href="/search?value1=Maria+Mezei&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Mezei Maria</a>, <a href="/search?value1=Martha+Neary&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Neary Martha</a>, <a href="/search?value1=Mario+Poljak&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Poljak Mario</a>, <a href="/search?value1=Ard+van+Sighem&option1=author&noRedirect=true" class="nonDisambigAuthorLink">van Sighem Ard</a>, <a href="/search?value1=Chris+Verhofstede&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Verhofstede Chris</a>, <a href="/search?value1=Andrew+J+Amato-Gauci&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Amato-Gauci Andrew J</a>, <a href="/search?value1=Eeva+K+Broberg&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Broberg Eeva K</a></span>. Piloting a surveillance system for HIV drug resistance in the European Union. <a href="/content/ecdc">Euro Surveill.</a> 2019;24(19):pii=1800390. <a href="https://doi.org/10.2807/1560-7917.ES.2019.24.19.1800390" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2019.24.19.1800390</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 16 Jul 2018;&nbsp;&nbsp; <span class="generated">Accepted</span>: 11 Apr 2019 </span> </p>
/content/10.2807/1560-7917.ES.2019.24.19.1800390
/content/10.2807/1560-7917.ES.2019.24.19.1800390
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