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Abstract

Background

The total incidence of invasive meningococcal disease (IMD) in Europe has been declining in recent years; however, a rising incidence due to serogroup W (MenW), predominantly sequence type 11 (ST-11), clonal complex 11 (cc11), was reported in some European countries.

Aim

The aim of this study was to compile the most recent laboratory surveillance data on MenW IMD from several European countries to assess recent trends in Europe.

Methods

In this observational, retrospective study, IMD surveillance data collected from 2013–17 by national reference laboratories and surveillance units from 13 European countries were analysed using descriptive statistics.

Results

The overall incidence of IMD has been stable during the study period. Incidence of MenW IMD per 100,000 population (2013: 0.03; 2014: 0.05; 2015: 0.08; 2016: 0.11; 2017: 0.11) and the proportion of this serogroup among all invasive cases (2013: 5% (116/2,216); 2014: 9% (161/1,761); 2015: 13% (271/2,074); 2016: 17% (388/2,222); 2017: 19% (393/2,112)) continuously increased. The most affected countries were England, the Netherlands, Switzerland and Sweden. MenW was more frequent in older age groups (≥ 45 years), while the proportion in children (< 15 years) was lower than in other age groups. Of the culture-confirmed MenW IMD cases, 80% (615/767) were caused by hypervirulent cc11.

Conclusion

During the years 2013–17, an increase in MenW IMD, mainly caused by MenW cc11, was observed in the majority of European countries. Given the unpredictable nature of meningococcal spread and the epidemiological potential of cc11, European countries may consider preventive strategies adapted to their contexts.

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/content/10.2807/1560-7917.ES.2019.24.14.1800245
2019-04-04
2024-11-22
http://instance.metastore.ingenta.com/content/10.2807/1560-7917.ES.2019.24.14.1800245
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Increase of invasive meningococcal serogroup W disease in Europe, 2013 to 2017
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=Manuel+Krone&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Krone Manuel</a>, <a href="/search?value1=Steve+Gray&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Gray Steve</a>, <a href="/search?value1=Raquel+Abad&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Abad Raquel</a>, <a href="/search?value1=Anna+Skoczy%C5%84ska&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Skoczyńska Anna</a>, <a href="/search?value1=Paola+Stefanelli&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Stefanelli Paola</a>, <a href="/search?value1=Arie+van+der+Ende&option1=author&noRedirect=true" class="nonDisambigAuthorLink">van der Ende Arie</a>, <a href="/search?value1=Georgina+Tzanakaki&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Tzanakaki Georgina</a>, <a href="/search?value1=Paula+M%C3%B6lling&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Mölling Paula</a>, <a href="/search?value1=Maria+Jo%C3%A3o+Sim%C3%B5es&option1=author&noRedirect=true" class="nonDisambigAuthorLink">João Simões Maria</a>, <a href="/search?value1=Pavla+K%C5%99%C3%AD%C5%BEov%C3%A1&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Křížová Pavla</a>, <a href="/search?value1=St%C3%A9phane+Emonet&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Emonet Stéphane</a>, <a href="/search?value1=Dominique+A.+Caugant&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Caugant Dominique A.</a>, <a href="/search?value1=Maija+Toropainen&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Toropainen Maija</a>, <a href="/search?value1=Julio+Vazquez&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Vazquez Julio</a>, <a href="/search?value1=Izabela+Wa%C5%9Bko&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Waśko Izabela</a>, <a href="/search?value1=Mirjam+J.+Knol&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Knol Mirjam J.</a>, <a href="/search?value1=Susanne+Jacobsson&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Jacobsson Susanne</a>, <a href="/search?value1=C%C3%A9lia+Rodrigues+Bettencourt&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Rodrigues Bettencourt Célia</a>, <a href="/search?value1=Martin+Musilek&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Musilek Martin</a>, <a href="/search?value1=Rita+Born&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Born Rita</a>, <a href="/search?value1=Ulrich+Vogel&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Vogel Ulrich</a>, <a href="/search?value1=Ray+Borrow&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Borrow Ray</a></span>. Increase of invasive meningococcal serogroup W disease in Europe, 2013 to 2017. <a href="/content/ecdc">Euro Surveill.</a> 2019;24(14):pii=1800245. <a href="https://doi.org/10.2807/1560-7917.ES.2019.24.14.1800245" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2019.24.14.1800245</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 04 May 2018;&nbsp;&nbsp; <span class="generated">Accepted</span>: 05 Jan 2019 </span> </p>
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