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Abstract

Introduction

Emergence of resistance determinants of and has undermined the antimicrobial effectiveness of the last line drugs carbapenems and colistin.

Aim

This work aimed to assess the prevalence of and in strains collected from food in Shenzhen, China, during the period 2015 to 2017.

Methods

Multidrug-resistant strains were isolated from food samples. Plasmids encoding or genes were characterised and compared with plasmids found in clinical isolates.

Results

Among 1,166 non-repeated cephalosporin-resistant strains isolated from 2,147 food samples, 390 and 42, respectively, were resistant to colistin and meropenem, with five strains being resistant to both agents. The rate of resistance to colistin increased significantly (p < 0.01) from 26% in 2015 to 46% in 2017, and that of meropenem resistance also increased sharply from 0.3% in 2015 to 17% in 2017 (p < 0.01). All meropenem-resistant strains carried a plasmid-borne gene. Among the colistin-resistant strains, three types of -bearing plasmids were determined. Plasmid sequencing indicated that these and -bearing plasmids were structurally similar to those commonly recovered from clinical isolates. Interestingly, both -bearing and -bearing plasmids were transferrable to strain J53 under selection by meropenem, yet only -bearing plasmids were transferrable under colistin selection.

Conclusion

These findings might suggest that mobile elements harbouring and have been acquired by animal strains and transmitted to our food products, highlighting a need to prevent a spike in the rate of drug resistant food-borne infections.

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This work is licensed under a Creative Commons Attribution 4.0 International License.
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A corrected article has been published for this content:
Erratum for Euro Surveill. 2019;24(13)
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2019-03-28
2024-12-24
/content/10.2807/1560-7917.ES.2019.24.13.1800113
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Increased prevalence of Escherichia coli strains from food carrying blaNDM and mcr-1-bearing plasmids that structurally resemble those of clinical strains, China, 2015 to 2017
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=Xiaobo+Liu&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Liu Xiaobo</a>, <a href="/search?value1=Shu+Geng&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Geng Shu</a>, <a href="/search?value1=Edward+Wai-Chi+Chan&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Chan Edward Wai-Chi</a>, <a href="/search?value1=Sheng+Chen&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Chen Sheng</a></span>. Increased prevalence of Escherichia coli strains from food carrying blaNDM and mcr-1-bearing plasmids that structurally resemble those of clinical strains, China, 2015 to 2017. <a href="/content/ecdc">Euro Surveill.</a> 2019;24(13):pii=1800113. <a href="https://doi.org/10.2807/1560-7917.ES.2019.24.13.1800113" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2019.24.13.1800113</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 12 Mar 2018;&nbsp;&nbsp; <span class="generated">Accepted</span>: 07 Jul 2018 </span> </p>
/content/10.2807/1560-7917.ES.2019.24.13.1800113
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