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Abstract

Introduction

Influenza vaccine is recommended for the entire population in Israel. We assessed influenza vaccine effectiveness (VE) for the 2014/15 and 2015/16 seasons in Israel, for the first time. Combined nose and throat swab specimens were collected from patients with influenza-like illness (ILI) presenting to sentinel primary care clinics and tested for influenza virus by RT-PCR. VE of the trivalent inactivated vaccine (TIV) was assessed using test-negative case–control design. During the 2014/15 season 1,142 samples were collected; 327 (28.6%) were positive for influenza, 83.8% A(H3N2), 5.8% A(H1N1)pdm09, 9.2% B and 1.2% A un-subtyped. Adjusted VE against all influenza viruses for this influenza season was −4.8% (95% confidence interval (CI): −54.8 to 29.0) and against influenza A(H3N2), it was −15.8% (95% CI: −72.8 to 22.4). For the 2015/16 season, 1,919 samples were collected; 853 (44.4%) were positive for influenza, 43.5% A(H1N1)pdm09, 57% B, 0.7% A(H3N2) and 11 samples positive for both A(H1N1)pdm09 and B. Adjusted VE against all influenza viruses for this influenza season was 8.8% (95% CI: −25.1 to 33.5), against influenza A(H1N1)pdm09, it was 32.3% (95% CI: (−4.3 to 56.1) and against influenza B, it was −2.2% (95% CI: (−47.0 to 29.0). Using samples from patients with ILI visiting sentinel clinics in Israel, we demonstrated the feasibility of influenza VE estimation in Israel.

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/content/10.2807/1560-7917.ES.2018.23.7.17-00026
2018-02-15
2024-12-22
/content/10.2807/1560-7917.ES.2018.23.7.17-00026
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Effectiveness of influenza vaccine in preventing medically-attended influenza virus infection in primary care, Israel, influenza seasons 2014/15 and 2015/16
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=Hamutal+Yaron-Yakoby&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Yaron-Yakoby Hamutal</a>, <a href="/search?value1=Hanna+Sefty&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Sefty Hanna</a>, <a href="/search?value1=Rakefet+Pando&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Pando Rakefet</a>, <a href="/search?value1=Rita+Dichtiar&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Dichtiar Rita</a>, <a href="/search?value1=Mark+A+Katz&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Katz Mark A</a>, <a href="/search?value1=Yaniv+Stein&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Stein Yaniv</a>, <a href="/search?value1=Michal+Mandelboim&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Mandelboim Michal</a>, <a href="/search?value1=Ella+Mendelson&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Mendelson Ella</a>, <a href="/search?value1=Tamy+Shohat&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Shohat Tamy</a>, <a href="/search?value1=Aharona+Glatman-Freedman&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Glatman-Freedman Aharona</a>, <a href="/search?value1=the+Israeli+Influenza+Surveillance+Network+%28IISN%29&option1=author&noRedirect=true" class="nonDisambigAuthorLink">the Israeli Influenza Surveillance Network (IISN)</a></span>. Effectiveness of influenza vaccine in preventing medically-attended influenza virus infection in primary care, Israel, influenza seasons 2014/15 and 2015/16. <a href="/content/ecdc">Euro Surveill.</a> 2018;23(7):pii=17-00026. <a href="https://doi.org/10.2807/1560-7917.ES.2018.23.7.17-00026" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2018.23.7.17-00026</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 09 Jan 2017;&nbsp;&nbsp; <span class="generated">Accepted</span>: 18 Jul 2017 </span> </p>
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