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Abstract

Background

antibiotic resistance surveillance is important to maintain adequate treatment. We analysed 2007–15 data from the Gonococcal Resistance to Antimicrobials Surveillance (GRAS), which currently includes 19 of 25 sexually transmitted infection (STI) centres in the Netherlands. : From each patient with a gonorrhoea culture, the minimum inhibitory concentration (MIC) for several antibiotics was determined. Time trends were assessed by geometric means and linear regression of logarithmic MIC. Determinants for decreased susceptibility to ceftriaxone (MIC > 0.032 mg/L) and resistance to cefotaxime (MIC > 0.125 mg/L) and azithromycin (MIC > 0.5 mg/L) were assessed using stratified logistic regression. : 11,768 isolates were analysed. No ceftriaxone resistance was found. In 2015, 27 of 1,425 isolates (1.9%) were resistant to cefotaxime and 176 of 1,623 (10.9%) to azithromycin. Ceftriaxone susceptibility showed no trend (p = 0.96) during the study period, but cefotaxime MIC decreased (p < 0.0001) and azithromycin MIC increased (p < 0.0001) significantly. Concerning ceftriaxone, isolates of men who have sex with men (MSM) from 2013 (p = 0.0005) and 2014 (p = 0.0004) were significantly associated with decreased susceptibility. Significant determinants for cefotaxime resistance were having ≥ 6 partners for women (p = 0.0006). For azithromycin,

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2018-09-06
2024-11-26
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Trends and determinants of antimicrobial susceptibility of Neisseria gonorrhoeae in the Netherlands, 2007 to 2015
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=Sanne+HI+Hofstraat&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Hofstraat Sanne HI</a>, <a href="/search?value1=Hannelore+M+G%C3%B6tz&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Götz Hannelore M</a>, <a href="/search?value1=Alje+P+van+Dam&option1=author&noRedirect=true" class="nonDisambigAuthorLink">van Dam Alje P</a>, <a href="/search?value1=Marianne+AB+van+der+Sande&option1=author&noRedirect=true" class="nonDisambigAuthorLink">van der Sande Marianne AB</a>, <a href="/search?value1=Birgit+HB+van+Benthem&option1=author&noRedirect=true" class="nonDisambigAuthorLink">van Benthem Birgit HB</a></span>. Trends and determinants of antimicrobial susceptibility of Neisseria gonorrhoeae in the Netherlands, 2007 to 2015. <a href="/content/ecdc">Euro Surveill.</a> 2018;23(36):pii=1700565. <a href="https://doi.org/10.2807/1560-7917.ES.2018.23.36.1700565" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2018.23.36.1700565</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 11 Aug 2017;&nbsp;&nbsp; <span class="generated">Accepted</span>: 01 Aug 2018 </span> </p>
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    • Characteristics of gonorrhoea patients from Dutch STI centres participating in GRAS, 2007–2015

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