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Abstract

In February and March 2016, four cases of serogroup B invasive meningococcal disease (IMD) occurred over 3 weeks in a small area north of Lyon in the Auvergne-Rhône-Alpes region, France. There were no deaths but two cases had sequelae. This community outbreak was caused by a rare meningococcal strain of the clonal complex ST-32, covered by the 4CMenB/Bexsero vaccine. The incidence rate for serogroup B IMD in this area was 22.5 per 100,000 inhabitants, which is above the epidemic threshold (10/100,000). The number of cases observed was significantly higher than expected in the age group of 0–24 year-olds (standardised incidence ratio: 96). These results suggested the potential emergence of this invasive strain in this sub-population. In accordance with French recommendations, it was decided to vaccinate the population aged between 2 months and 24 years, living, working or studying in the epidemic area. The vaccination campaign took place from April to September 2016. Vaccination coverage was estimated at 47% for one dose and 40% for two doses. The lowest coverage estimations were observed for the age groups younger than 3 and 15–19 years. Enhanced epidemiological and microbiological surveillance reported a fifth case in June 2016, outside the epidemic area.

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/content/10.2807/1560-7917.ES.2018.23.28.1700590
2018-07-12
2024-12-26
/content/10.2807/1560-7917.ES.2018.23.28.1700590
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Community outbreak of serogroup B invasive meningococcal disease in Beaujolais, France, February to June 2016: from alert to targeted vaccination
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=Alexandra+Thabuis&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Thabuis Alexandra</a>, <a href="/search?value1=Karim+Tararbit&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Tararbit Karim</a>, <a href="/search?value1=Muhamed-Kheir+Taha&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Taha Muhamed-Kheir</a>, <a href="/search?value1=Dominique+Dejour-Salamanca&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Dejour-Salamanca Dominique</a>, <a href="/search?value1=Vincent+Ronin&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Ronin Vincent</a>, <a href="/search?value1=Isabelle+Parent+du+Chatelet&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Parent du Chatelet Isabelle</a>, <a href="/search?value1=Guillaume+Spaccaferri&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Spaccaferri Guillaume</a></span>. Community outbreak of serogroup B invasive meningococcal disease in Beaujolais, France, February to June 2016: from alert to targeted vaccination. <a href="/content/ecdc">Euro Surveill.</a> 2018;23(28):pii=1700590. <a href="https://doi.org/10.2807/1560-7917.ES.2018.23.28.1700590" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2018.23.28.1700590</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 24 Aug 2017;&nbsp;&nbsp; <span class="generated">Accepted</span>: 19 Jan 2018 </span> </p>
/content/10.2807/1560-7917.ES.2018.23.28.1700590
/content/10.2807/1560-7917.ES.2018.23.28.1700590
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