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Abstract

We describe a gonorrhoea case with combined high-level azithromycin resistance and ceftriaxone resistance. In February 2018, a heterosexual male was diagnosed with gonorrhoea in the United Kingdom following sexual intercourse with a locally resident female in Thailand and failed treatment with ceftriaxone plus doxycycline and subsequently spectinomycin. Resistance arose from two mechanisms combining for the first time in a genetic background similar to a commonly circulating strain. Urgent action is essential to prevent further spread.

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/content/10.2807/1560-7917.ES.2018.23.27.1800323
2018-07-05
2024-11-21
http://instance.metastore.ingenta.com/content/10.2807/1560-7917.ES.2018.23.27.1800323
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Gonorrhoea treatment failure caused by a Neisseria gonorrhoeae strain with combined ceftriaxone and high-level azithromycin resistance, England, February 2018
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=David+W+Eyre&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Eyre David W</a>, <a href="/search?value1=Nicholas+D+Sanderson&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Sanderson Nicholas D</a>, <a href="/search?value1=Emily+Lord&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Lord Emily</a>, <a href="/search?value1=Natasha+Regisford-Reimmer&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Regisford-Reimmer Natasha</a>, <a href="/search?value1=Kevin+Chau&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Chau Kevin</a>, <a href="/search?value1=Leanne+Barker&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Barker Leanne</a>, <a href="/search?value1=Markus+Morgan&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Morgan Markus</a>, <a href="/search?value1=Robert+Newnham&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Newnham Robert</a>, <a href="/search?value1=Daniel+Golparian&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Golparian Daniel</a>, <a href="/search?value1=Magnus+Unemo&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Unemo Magnus</a>, <a href="/search?value1=Derrick+W+Crook&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Crook Derrick W</a>, <a href="/search?value1=Tim+EA+Peto&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Peto Tim EA</a>, <a href="/search?value1=Gwenda+Hughes&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Hughes Gwenda</a>, <a href="/search?value1=Michelle+J+Cole&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Cole Michelle J</a>, <a href="/search?value1=Helen+Fifer&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Fifer Helen</a>, <a href="/search?value1=Anne+Edwards&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Edwards Anne</a>, <a href="/search?value1=Monique+I+Andersson&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Andersson Monique I</a></span>. Gonorrhoea treatment failure caused by a Neisseria gonorrhoeae strain with combined ceftriaxone and high-level azithromycin resistance, England, February 2018. <a href="/content/ecdc">Euro Surveill.</a> 2018;23(27):pii=1800323. <a href="https://doi.org/10.2807/1560-7917.ES.2018.23.27.1800323" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2018.23.27.1800323</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 18 Jun 2018;&nbsp;&nbsp; <span class="generated">Accepted</span>: 04 Jul 2018 </span> </p>
/content/10.2807/1560-7917.ES.2018.23.27.1800323
/content/10.2807/1560-7917.ES.2018.23.27.1800323
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    • Gonorrhoea treatment failure caused by a Neisseria gonorrhoeae strain with combined ceftriaxone and high-level azithromycin resistance, England, February 2018: Supplement

    • Date:
      July 5, 2018 12:00 AM

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