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Abstract

Introduction

Carbapenemase-producing (CPE) have rarely been reported in dogs, and never in animals in Finland. However, in April 2015, two meropenem-resistant were identified from two dogs in one family. Both dogs suffered from chronic . Epidemiological and molecular investigations (pulsed-field gel electrophoresis (PFGE), multilocus sequence typing) were conducted to investigate the source of infection and transmission routes. In both dogs and one family member New Delhi metallo-beta-lactamase (NDM-5)-producing multidrug-resistant ST167 was found. Whole genome sequencing confirmed that the isolates were identical or only had one or two allelic differences. Additionally, the dogs and humans of the family carried an identical extended-spectrum beta-lactamase (ESBL) CTX-M-group 9 ST69 strain, indicating interspecies transmission. While the original source remains unclear, human-to-canine transmission is possible. No carbapenems had been administered to the dogs, but exposure to numerous other antimicrobials likely sustained the bacteria and supported its propagation in the canine host. To our knowledge, canine clinical NDM-5 in Europe, and confirmed CPE transmission between dogs and humans have not been previously reported. The screening of veterinary isolates for carbapenem resistance is highly recommended.

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/content/10.2807/1560-7917.ES.2018.23.27.1700497
2018-07-05
2024-12-22
/content/10.2807/1560-7917.ES.2018.23.27.1700497
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Sharing more than friendship – transmission of NDM-5 ST167 and CTX-M-9 ST69 Escherichia coli between dogs and humans in a family, Finland, 2015
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=Thomas+Gr%C3%B6nthal&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Grönthal Thomas</a>, <a href="/search?value1=Monica+%C3%96sterblad&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Österblad Monica</a>, <a href="/search?value1=Marjut+Eklund&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Eklund Marjut</a>, <a href="/search?value1=Jari+Jalava&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Jalava Jari</a>, <a href="/search?value1=Suvi+Nyk%C3%A4senoja&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Nykäsenoja Suvi</a>, <a href="/search?value1=Katariina+Pekkanen&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Pekkanen Katariina</a>, <a href="/search?value1=Merja+Rantala&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Rantala Merja</a></span>. Sharing more than friendship – transmission of NDM-5 ST167 and CTX-M-9 ST69 Escherichia coli between dogs and humans in a family, Finland, 2015. <a href="/content/ecdc">Euro Surveill.</a> 2018;23(27):pii=1700497. <a href="https://doi.org/10.2807/1560-7917.ES.2018.23.27.1700497" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2018.23.27.1700497</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 21 Jul 2017;&nbsp;&nbsp; <span class="generated">Accepted</span>: 03 Apr 2018 </span> </p>
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