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Abstract

The 2015/16 influenza season was the third season of the introduction of an intra-nasally administered live attenuated influenza vaccine (LAIV) for children in England. All children aged 2‒6 years were offered LAIV, and in addition, a series of geographically discrete areas piloted vaccinating school-age children 7‒11 years old. Influenza A(H1N1)pdm09 was the dominant circulating strain during 2015/16 followed by influenza B. We measured influenza vaccine uptake and the overall and indirect effect of vaccinating children of primary school -age, by comparing cumulative disease incidence in targeted and non-targeted age groups in vaccine pilot and non-pilot areas in England. Uptake of 57.9% (range: 43.6–72.0) was achieved in the five pilot areas for children aged 5‒11 years. In pilot areas, cumulative emergency department respiratory attendances, influenza-confirmed hospitalisations and intensive care unit admissions were consistently lower, albeit mostly non-significantly, in targeted and non-targeted age groups compared with non-pilot areas. Effect sizes were less for adults and more severe endpoints. Vaccination of healthy primary school-age children with LAIV at moderately high levels continues to be associated with population-level reductions in influenza-related respiratory illness. Further work to evaluate the population-level impact of the programme is required.

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/content/10.2807/1560-7917.ES.2018.23.25.1700496
2018-06-21
2024-11-21
http://instance.metastore.ingenta.com/content/10.2807/1560-7917.ES.2018.23.25.1700496
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Uptake and impact of vaccinating primary school-age children against influenza: experiences of a live attenuated influenza vaccine programme, England, 2015/16
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=Richard+G+Pebody&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Pebody Richard G</a>, <a href="/search?value1=Mary+A+Sinnathamby&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Sinnathamby Mary A</a>, <a href="/search?value1=Fiona+Warburton&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Warburton Fiona</a>, <a href="/search?value1=Nick+Andrews&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Andrews Nick</a>, <a href="/search?value1=Nicola+L+Boddington&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Boddington Nicola L</a>, <a href="/search?value1=Hongxin+Zhao&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Zhao Hongxin</a>, <a href="/search?value1=Ivelina+Yonova&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Yonova Ivelina</a>, <a href="/search?value1=Joanna+Ellis&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Ellis Joanna</a>, <a href="/search?value1=Elise+Tessier&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Tessier Elise</a>, <a href="/search?value1=Matthew+Donati&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Donati Matthew</a>, <a href="/search?value1=Alex+J+Elliot&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Elliot Alex J</a>, <a href="/search?value1=Helen+E+Hughes&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Hughes Helen E</a>, <a href="/search?value1=Sameera+Pathirannehelage&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Pathirannehelage Sameera</a>, <a href="/search?value1=Rachel+Byford&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Byford Rachel</a>, <a href="/search?value1=Gillian+E+Smith&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Smith Gillian E</a>, <a href="/search?value1=Simon+de+Lusignan&option1=author&noRedirect=true" class="nonDisambigAuthorLink">de Lusignan Simon</a>, <a href="/search?value1=Maria+Zambon&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Zambon Maria</a></span>. Uptake and impact of vaccinating primary school-age children against influenza: experiences of a live attenuated influenza vaccine programme, England, 2015/16. <a href="/content/ecdc">Euro Surveill.</a> 2018;23(25):pii=1700496. <a href="https://doi.org/10.2807/1560-7917.ES.2018.23.25.1700496" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2018.23.25.1700496</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 21 Jul 2017;&nbsp;&nbsp; <span class="generated">Accepted</span>: 21 Dec 2017 </span> </p>
/content/10.2807/1560-7917.ES.2018.23.25.1700496
/content/10.2807/1560-7917.ES.2018.23.25.1700496
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