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Abstract

Invasive meningococcal disease surveillance in Europe combines isolate characterisation and epidemiological data to support public health intervention. A representative European Meningococcal Strain Collection (EMSC) of IMD isolates was obtained, and whole genome sequenced to characterise 799 EMSC isolates from the epidemiological year July 2011–June 2012. To establish a genome library (GL), the isolate information was deposited in the pubMLST.org/neisseria database. Genomes were curated and annotated at 2,429 meningococcal loci, including those defining clonal complex, capsule, antigens, and antimicrobial resistance. Most genomes contained genes encoding B (n = 525; 65.7%) or C (n = 163; 20.4%) capsules; isolates were genetically highly diverse, with >20 genomic lineages, five of which comprising 60.7% (n = 485) of isolates. There were >350 antigenic fine-types: 307 were present once, the most frequent (P1.7-2,4:F5-1) comprised 8% (n = 64) of isolates. Each genome was characterised for Bexsero Antigen Sequence Typing (BAST): 25.5% (n = 204) of isolates contained alleles encoding the fHbp and/or the PorA VR1 vaccine component, but most genomes (n = 513; 64.2%) did not contain the NadA component. EMSC-GL will support an integrated surveillance of disease-associated genotypes in Europe, enabling the monitoring of hyperinvasive lineages, outbreak identification, and supporting vaccine programme implementation.

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/content/10.2807/1560-7917.ES.2018.23.20.17-00474
2018-05-17
2024-12-30
/content/10.2807/1560-7917.ES.2018.23.20.17-00474
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Establishment of the European meningococcal strain collection genome library (EMSC-GL) for the 2011 to 2012 epidemiological year
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=Holly+B+Bratcher&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Bratcher Holly B</a>, <a href="/search?value1=Carina+Brehony&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Brehony Carina</a>, <a href="/search?value1=Sigrid+Heuberger&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Heuberger Sigrid</a>, <a href="/search?value1=Despo+Pieridou-Bagatzouni&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Pieridou-Bagatzouni Despo</a>, <a href="/search?value1=Pavla+K%C5%99%C3%AD%C5%BEov%C3%A1&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Křížová Pavla</a>, <a href="/search?value1=Steen+Hoffmann&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Hoffmann Steen</a>, <a href="/search?value1=Maija+Toropainen&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Toropainen Maija</a>, <a href="/search?value1=Muhamed-Kheir+Taha&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Taha Muhamed-Kheir</a>, <a href="/search?value1=Heike+Claus&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Claus Heike</a>, <a href="/search?value1=Georgina+Tzanakaki&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Tzanakaki Georgina</a>, <a href="/search?value1=T%C3%ADmea+Erd%C3%B4si&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Erdôsi Tímea</a>, <a href="/search?value1=Jelena+Galajeva&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Galajeva Jelena</a>, <a href="/search?value1=Arie+van+der+Ende&option1=author&noRedirect=true" class="nonDisambigAuthorLink">van der Ende Arie</a>, <a href="/search?value1=Anna+Skoczy%C5%84ska&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Skoczyńska Anna</a>, <a href="/search?value1=Marina+Pana&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Pana Marina</a>, <a href="/search?value1=Alena+Vacul%C3%ADkov%C3%A1&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Vaculíková Alena</a>, <a href="/search?value1=Metka+Paragi&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Paragi Metka</a>, <a href="/search?value1=Martin+CJ+Maiden&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Maiden Martin CJ</a>, <a href="/search?value1=Dominique+A+Caugant&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Caugant Dominique A</a></span>. Establishment of the European meningococcal strain collection genome library (EMSC-GL) for the 2011 to 2012 epidemiological year. <a href="/content/ecdc">Euro Surveill.</a> 2018;23(20):pii=17-00474. <a href="https://doi.org/10.2807/1560-7917.ES.2018.23.20.17-00474" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2018.23.20.17-00474</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 14 Jul 2017;&nbsp;&nbsp; <span class="generated">Accepted</span>: 27 Oct 2017 </span> </p>
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