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Abstract

Background

Vaccine hesitancy (VH) is prominent in France. This study aimed to estimate the prevalence and socio-demographic correlates of VH in sub-groups of the French population and to investigate the association of VH with both vaccine uptake and perceived risk–benefit balance (RBB) for four vaccines. : During the 2016 Health Barometer – a national cross-sectional telephone survey in a representative sample of the French population – parents of 1–15 year-old children, parents of 11–15 year-old girls and elderly people aged 65–75 years were asked about VH (using three questions adapted from the World Health Organization definition), vaccine uptake and perceived RBB for measles and hepatitis B (children’s parents), human papillomavirus (girls’ parents) and seasonal influenza (elderly people) vaccines. : A total of 3,938 parents including 959 girls' parents – and 2,418 elderly people were interviewed. VH prevalence estimates were 46% (95% confidence interval (CI): 44–48) among parents, 48% (95%CI: 45–51) among girls’ parents and 35% (95% CI: 33–36) among elderly people, with higher estimates associated with high education level, children’s age (10–15 years), and, for the elderly, poor perception of health status. VH was associated with uncertainty about and/or an unfavourable perception of vaccines’ RBB for the four vaccines and with lower self-reported vaccine uptake, except for human papillomavirus vaccine in girls. Results were confirmed by multivariable analysis. : Further research is needed to study the association between VH and vaccine uptake for other vaccines, and to design and validate measurement tools to monitor VH over time.

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/content/10.2807/1560-7917.ES.2018.23.17.17-00816
2018-04-26
2024-03-29
http://instance.metastore.ingenta.com/content/10.2807/1560-7917.ES.2018.23.17.17-00816
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References

  1. Larson HJ, de Figueiredo A, Xiahong Z, Schulz WS, Verger P, Johnston IG, et al. The state of vaccine confidence 2016: global insights through a 67-country survey. EBioMedicine. 2016;12:295-301.  https://doi.org/10.1016/j.ebiom.2016.08.042  PMID: 27658738 
  2. World Health Organization (WHO), SAGE Working Group on Vaccine Hesitancy. Report of the SAGE working group on vaccine hesitancy. Geneva: WHO; 01 Oct 2014. [Accessed 17 Feb 2017]. Available from: www.who.int/immunization/sage/meetings/2014/october/1_Report_WORKING_GROUP_vaccine_hesitancy_final.pdf
  3. MacDonald NESAGE Working Group on Vaccine Hesitancy. Vaccine hesitancy: Definition, scope and determinants. Vaccine. 2015;33(34):4161-4.  https://doi.org/10.1016/j.vaccine.2015.04.036  PMID: 25896383 
  4. Peretti-Watel P, Larson HJ, Ward JK, Schulz WS, Verger P. Vaccine hesitancy: clarifying a theoretical framework for an ambiguous notion. PLoS Curr. 2015;7:ecurrents.outbreaks.6844c80ff9f5b273f34c91f71b7fc289. PMID: 25789201 
  5. Peretti-Watel P, Verger P, Raude J, Constant A, Gautier A, Jestin C, et al. Dramatic change in public attitudes towards vaccination during the 2009 influenza A(H1N1) pandemic in France. Euro Surveill. 2013;18(44):20623.  https://doi.org/10.2807/1560-7917.ES2013.18.44.20623  PMID: 24176658 
  6. Opel DJ, Taylor JA, Mangione-Smith R, Solomon C, Zhao C, Catz S, et al. Validity and reliability of a survey to identify vaccine-hesitant parents. Vaccine. 2011;29(38):6598-605.  https://doi.org/10.1016/j.vaccine.2011.06.115  PMID: 21763384 
  7. Gilkey MB, Reiter PL, Magnus BE, McRee AL, Dempsey AF, Brewer NT. Validation of the vaccination confidence scale: a brief measure to identify parents at risk for refusing adolescent vaccines. Acad Pediatr. 2016;16(1):42-9.  https://doi.org/10.1016/j.acap.2015.06.007  PMID: 26300368 
  8. Richard JB, Andler R, Gautier A, Guignard R, Leon C, Beck F. Effects of using an Overlapping Dual-Frame Design on Estimates of Health Behaviors: A French General Population Telephone Survey. J Surv Stat Methodol. 2017;5(2):254-74. https://doi.org/10.1093/jssam/smw028
  9. French Health Ministry. Immunization schedule and vaccine recommendations 2016 (in French). Paris: French Health Ministry; 2016. Available from: http://social-sante.gouv.fr/IMG/pdf/calendrier_vaccinal_2016.pdf
  10. Sante Publique France. (SPF; French Public Health). Couverture vaccinale. [Vaccine coverage]; 2016. French. Available from: http://invs.santepubliquefrance.fr/Dossiers-thematiques/Maladies-infectieuses/Maladies-a-prevention-vaccinale/Couverture-vaccinale/Donnees
  11. Gust DA, Darling N, Kennedy A, Schwartz B. Parents with doubts about vaccines: which vaccines and reasons why. Pediatrics. 2008;122(4):718-25.  https://doi.org/10.1542/peds.2007-0538  PMID: 18829793 
  12. National Institute of Statistics and Economic Studies. Definitions and methods. Definitions. Consumption unit. [Accessed 28 Sep 2015]. Available from: www.insee.fr/en/methodes/default.asp?page=definitions/unite-consommation.htm.
  13. Rogerson P. Statistical Methods for Geography. London: SAGE Publications Ltd; 2001.
  14. Fagerland MW, Hosmer DW. A Generalized Hosmer Lemeshow Goodness-of-Fit Test for Multinomial Logistic Regression Models. Stata J. 2012;12(3):447-53.
  15. Smith PJ, Humiston SG, Marcuse EK, Zhao Z, Dorell CG, Howes C, et al. Parental delay or refusal of vaccine doses, childhood vaccination coverage at 24 months of age, and the Health Belief Model. Public Health Rep. 2011;126Suppl 2;135-46.  https://doi.org/10.1177/00333549111260S215  PMID: 21812176 
  16. Gilkey MB, Calo WA, Marciniak MW, Brewer NT. Parents who refuse or delay HPV vaccine: Differences in vaccination behavior, beliefs, and clinical communication preferences. Hum Vaccin Immunother. 2017;13(3):680-6.  https://doi.org/10.1080/21645515.2016.1247134  PMID: 27763818 
  17. Bocquier A, Ward J, Raude J, Peretti-Watel P, Verger P. Socioeconomic differences in childhood vaccination in developed countries: a systematic review of quantitative studies. Expert Rev Vaccines. 2017;16(11):1107-18.  https://doi.org/10.1080/14760584.2017.1381020  PMID: 28914112 
  18. Gilkey MB, McRee A-L, Brewer NT. Forgone vaccination during childhood and adolescence: findings of a statewide survey of parents. Prev Med. 2013;56(3-4):202-6.  https://doi.org/10.1016/j.ypmed.2012.12.019  PMID: 23295175 
  19. Velan B, Kaplan G, Ziv A, Boyko V, Lerner-Geva L. Major motives in non-acceptance of A/H1N1 flu vaccination: the weight of rational assessment. Vaccine. 2011;29(6):1173-9.  https://doi.org/10.1016/j.vaccine.2010.12.006  PMID: 21167862 
  20. Verger P, Bocquier A, Vergélys C, Ward J, Peretti-Watel P. Flu vaccination among patients with diabetes: motives, perceptions, trust, and risk culture - A qualitative survey. BMC Public Health. 2018. Forthcoming.
  21. Roberts JR, Thompson D, Rogacki B, Hale JJ, Jacobson RM, Opel DJ, et al. Vaccine hesitancy among parents of adolescents and its association with vaccine uptake. Vaccine. 2015;33(14):1748-55.  https://doi.org/10.1016/j.vaccine.2015.01.068  PMID: 25659278 
  22. Darden PM, Thompson DM, Roberts JR, Hale JJ, Pope C, Naifeh M, et al. Reasons for not vaccinating adolescents: National Immunization Survey of Teens, 2008-2010. Pediatrics. 2013;131(4):645-51.  https://doi.org/10.1542/peds.2012-2384  PMID: 23509163 
  23. Bratic JS, Seyferth ER, Bocchini JA Jr. Update on barriers to human papillomavirus vaccination and effective strategies to promote vaccine acceptance. Curr Opin Pediatr. 2016;28(3):407-12.  https://doi.org/10.1097/MOP.0000000000000353  PMID: 27093354 
  24. Uhart M, Adam M, Dahlab A, Bresse X. Loss of chance associated with sub-optimal HPV vaccination coverage rate in France. Papillomavirus Res. 2017;3:73-9.  https://doi.org/10.1016/j.pvr.2017.02.004  PMID: 28720460 
  25. Ward JK, Colgrove J, Verger P. France’s risky vaccine mandates. Science. 2017;358(6362):458-9. PMID: 29074762 
  26. Agrinier N, Le Maréchal M, Fressard L, Verger P, Pulcini C. Discrepancies between general practitioners’ vaccination recommendations for their patients and practices for their children. Clin Microbiol Infect. 2017;23(5):311-7.  https://doi.org/10.1016/j.cmi.2016.08.019  PMID: 27599689 
  27. Collange F, Fressard L, Pulcini C, Sebbah R, Peretti-Watel P, Verger P. General practitioners’ attitudes and behaviors toward HPV vaccination: A French national survey. Vaccine. 2016;34(6):762-8.  https://doi.org/10.1016/j.vaccine.2015.12.054  PMID: 26752063 
  28. Jarrett C, Wilson R, O’Leary M, Eckersberger E, Larson HJSAGE Working Group on Vaccine Hesitancy. Strategies for addressing vaccine hesitancy - A systematic review. Vaccine. 2015;33(34):4180-90.  https://doi.org/10.1016/j.vaccine.2015.04.040  PMID: 25896377 
  29. Bouhnik AD, Bendiane MK, Cortaredona S, Sagaon Teyssier L, Rey D, Berenger C, et al. members of VICAN Group. The labour market, psychosocial outcomes and health conditions in cancer survivors: protocol for a nationwide longitudinal survey 2 and 5 years after cancer diagnosis (the VICAN survey). BMJ Open. 2015;5(3):e005971.  https://doi.org/10.1136/bmjopen-2014-005971  PMID: 25805526 
  30. Mac Donald R, Baken L, Nelson A, Nichol KL. Validation of self-report of influenza and pneumococcal vaccination status in elderly outpatients. Am J Prev Med. 1999;16(3):173-7.  https://doi.org/10.1016/S0749-3797(98)00159-7  PMID: 10198654 
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