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Abstract

OXA-48-like beta-lactamase producing bacteria are now endemic in several European and Mediterranean countries. Among this carbapenemase family, the OXA-48 and OXA-181 variants predominate, whereas other variants such as OXA-204 are rarely reported. Here, we report the molecular epidemiology of a collection of OXA-204-positive enterobacterial isolates (n = 29) recovered in France between October 2012 and May 2014. This study describes the first outbreak of OXA-204-producing in Europe, involving 12 isolates of an ST90 clone and nine isolates of an ST147 clone. All isolates co-produced the cephalosporinase CMY-4, and 60% of them co-produced the extended-spectrum beta-lactamase CTX-M-15. The gene was located on a 150-kb IncA/C plasmid, isolated from various enterobacterial species in the same patient, indicating a high conjugative ability of this genetic vehicle.

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2017-12-07
2024-12-23
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Analysis of OXA-204 carbapenemase-producing Enterobacteriaceae reveals possible endoscopy-associated transmission, France, 2012 to 2014
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=Ana%C3%AFs+Potron&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Potron Anaïs</a>, <a href="/search?value1=Sandrine+Bernabeu&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Bernabeu Sandrine</a>, <a href="/search?value1=Ga%C3%ABlle+Cuzon&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Cuzon Gaëlle</a>, <a href="/search?value1=Val%C3%A9rie+Ponti%C3%A8s&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Pontiès Valérie</a>, <a href="/search?value1=Herv%C3%A9+Blanchard&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Blanchard Hervé</a>, <a href="/search?value1=Elise+Seringe&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Seringe Elise</a>, <a href="/search?value1=Thierry+Naas&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Naas Thierry</a>, <a href="/search?value1=Patrice+Nordmann&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Nordmann Patrice</a>, <a href="/search?value1=Laurent+Dortet&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Dortet Laurent</a></span>. Analysis of OXA-204 carbapenemase-producing Enterobacteriaceae reveals possible endoscopy-associated transmission, France, 2012 to 2014. <a href="/content/ecdc">Euro Surveill.</a> 2017;22(49):pii=17-00048. <a href="https://doi.org/10.2807/1560-7917.ES.2017.22.49.17-00048" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2017.22.49.17-00048</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 16 Jan 2017;&nbsp;&nbsp; <span class="generated">Accepted</span>: 23 May 2017 </span> </p>
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