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Abstract

We describe a multidrug-resistant infection with ceftriaxone resistance and azithromycin intermediate resistance in a heterosexual man in Denmark, 2017. Whole genome sequencing of the strain GK124 identified MSLT ST1903, NG-MAST ST1614 and all relevant resistance determinants including similar penA resistance mutations previously described in ceftriaxone-resistant gonococcal strains. Although treatment with ceftriaxone 0.5 g plus azithromycin 2 g was successful, increased awareness of spread of gonococcal strains threatening the recommended dual therapy is crucial.

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/content/10.2807/1560-7917.ES.2017.22.42.17-00659
2017-10-19
2024-11-27
http://instance.metastore.ingenta.com/content/10.2807/1560-7917.ES.2017.22.42.17-00659
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Multidrug-resistant Neisseria gonorrhoeae infection with ceftriaxone resistance and intermediate resistance to azithromycin, Denmark, 2017
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=David+Terkelsen&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Terkelsen David</a>, <a href="/search?value1=Jacob+Tolstrup&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Tolstrup Jacob</a>, <a href="/search?value1=Camilla+Hundahl+Johnsen&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Johnsen Camilla Hundahl</a>, <a href="/search?value1=Ole+Lund&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Lund Ole</a>, <a href="/search?value1=Helle+Kiellberg+Larsen&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Larsen Helle Kiellberg</a>, <a href="/search?value1=Peder+Worning&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Worning Peder</a>, <a href="/search?value1=Magnus+Unemo&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Unemo Magnus</a>, <a href="/search?value1=Henrik+Westh&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Westh Henrik</a></span>. Multidrug-resistant Neisseria gonorrhoeae infection with ceftriaxone resistance and intermediate resistance to azithromycin, Denmark, 2017. <a href="/content/ecdc">Euro Surveill.</a> 2017;22(42):pii=17-00659. <a href="https://doi.org/10.2807/1560-7917.ES.2017.22.42.17-00659" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2017.22.42.17-00659</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 21 Sept 2017;&nbsp;&nbsp; <span class="generated">Accepted</span>: 18 Oct 2017 </span> </p>
/content/10.2807/1560-7917.ES.2017.22.42.17-00659
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