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Abstract

In Europe, enterovirus A71 (EV-A71) has primarily been associated with sporadic cases of neurological disease. The recent emergence of new genotypes and larger outbreaks with severely ill patients demonstrates a potential for the spread of new, highly pathogenic EV-A71 strains. Detection and characterisation of these new emerging EV variants is challenging as standard EV assays may not be adequate, necessitating the use of whole genome analysis.

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/content/10.2807/1560-7917.ES.2017.22.26.30565
2017-06-29
2024-11-06
http://instance.metastore.ingenta.com/content/10.2807/1560-7917.ES.2017.22.26.30565
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References

  1. Badran SA, Midgley S, Andersen P, Böttiger B. Clinical and virological features of enterovirus 71 infections in Denmark, 2005 to 2008. Scand J Infect Dis. 2011;43(8):642-8.  https://doi.org/10.3109/00365548.2011.577094  PMID: 21526904 
  2. Fischer TK, Nielsen AY, Sydenham TV, Andersen PH, Andersen B, Midgley SE. Emergence of enterovirus 71 C4a in Denmark, 2009 to 2013. Euro Surveill. 2014;19(38):20911.  https://doi.org/10.2807/1560-7917.ES2014.19.38.20911  PMID: 25306878 
  3. Zhang Y, Tan X, Cui A, Mao N, Xu S, Zhu Z, et al. Complete genome analysis of the C4 subgenotype strains of enterovirus 71: predominant recombination C4 viruses persistently circulating in China for 14 years. PLoS One. 2013;8(2):e56341.  https://doi.org/10.1371/journal.pone.0056341  PMID: 23441179 
  4. Liu Y, Fu C, Wu S, Chen X, Shi Y, Zhou B, et al. A novel finding for enterovirus virulence from the capsid protein VP1 of EV71 circulating in mainland China. Virus Genes. 2014;48(2):260-72.  https://doi.org/10.1007/s11262-014-1035-2  PMID: 24442718 
  5. Böttcher S, Obermeier PE, Neubauer K, Diedrich S, Laboratory Network for Enterovirus Diagnostics. Recombinant Enterovirus A71 Subgenogroup C1 Strains, Germany, 2015. Emerg Infect Dis. 2016;22(10):1843-6.  https://doi.org/10.3201/eid2210.160357  PMID: 27439117 
  6. Karrasch M, Fischer E, Scholten M, Sauerbrei A, Henke A, Renz DM, et al. A severe pediatric infection with a novel enterovirus A71 strain, Thuringia, Germany. J Clin Virol. 2016;84:90-5.  https://doi.org/10.1016/j.jcv.2016.09.007  PMID: 27771495 
  7. Condell O, Midgley S, Christiansen CB, Chen M, Chen Nielsen X, Ellermann-Eriksen S, et al. Evaluation of the enterovirus laboratory surveillance system in Denmark, 2010 to 2013. Euro Surveill. 2016;21(18):30218.  https://doi.org/10.2807/1560-7917.ES.2016.21.18.30218  PMID: 27173593 
  8. Nasri D, Bouslama L, Omar S, Saoudin H, Bourlet T, Aouni M, et al. Typing of human enterovirus by partial sequencing of VP2. J Clin Microbiol. 2007;45(8):2370-9.  https://doi.org/10.1128/JCM.00093-07  PMID: 17537940 
  9. Nix WA, Oberste MS, Pallansch MA. Sensitive, seminested PCR amplification of VP1 sequences for direct identification of all enterovirus serotypes from original clinical specimens. J Clin Microbiol. 2006;44(8):2698-704.  https://doi.org/10.1128/JCM.00542-06  PMID: 16891480 
  10. Fonager J, Stegger M, Rasmussen LD, Poulsen MW, Rønn J, Andersen PS, et al. A universal primer-independent next-generation sequencing approach for investigations of norovirus outbreaks and novel variants. Sci Rep. 2017;7(1):813.  https://doi.org/10.1038/s41598-017-00926-x  PMID: 28400558 
  11. Simmonds P. SSE: a nucleotide and amino acid sequence analysis platform. BMC Res Notes. 2012;5(1):50.  https://doi.org/10.1186/1756-0500-5-50  PMID: 22264264 
  12. Tamura K, Stecher G, Peterson D, Filipski A, Kumar S. MEGA6: Molecular Evolutionary Genetics Analysis version 6.0. Mol Biol Evol. 2013;30(12):2725-9.  https://doi.org/10.1093/molbev/mst197  PMID: 24132122 
  13. Lole KS, Bollinger RC, Paranjape RS, Gadkari D, Kulkarni SS, Novak NG, et al. Full-length human immunodeficiency virus type 1 genomes from subtype C-infected seroconverters in India, with evidence of intersubtype recombination. J Virol. 1999;73(1):152-60. PMID: 9847317 
  14. Antona D, Kossorotoff M, Schuffenecker I, Mirand A, Leruez-Ville M, Bassi C, et al. Severe paediatric conditions linked with EV-A71 and EV-D68, France, May to October 2016. Euro Surveill. 2016;21(46):30402.  https://doi.org/10.2807/1560-7917.ES.2016.21.46.30402  PMID: 27918268 
Co-circulation of multiple subtypes of enterovirus A71 (EV- A71) genotype C, including novel recombinants characterised by use of whole genome sequencing (WGS), Denmark 2016
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=Sofie+E+Midgley&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Midgley Sofie E</a>, <a href="/search?value1=Astrid+G+Nielsen&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Nielsen Astrid G</a>, <a href="/search?value1=Ramona+Trebbien&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Trebbien Ramona</a>, <a href="/search?value1=Mille+W.+Poulsen&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Poulsen Mille W.</a>, <a href="/search?value1=Peter+H+Andersen&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Andersen Peter H</a>, <a href="/search?value1=Thea+K+Fischer&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Fischer Thea K</a></span>. Co-circulation of multiple subtypes of enterovirus A71 (EV- A71) genotype C, including novel recombinants characterised by use of whole genome sequencing (WGS), Denmark 2016. <a href="/content/ecdc">Euro Surveill.</a> 2017;22(26):pii=30565. <a href="https://doi.org/10.2807/1560-7917.ES.2017.22.26.30565" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2017.22.26.30565</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 19 May 2017;&nbsp;&nbsp; <span class="generated">Accepted</span>: 29 Jun 2017 </span> </p>
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