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Abstract

In the Valencian Community (Spain), the programme of maternal pertussis vaccination during pregnancy started in January 2015. The objective of this study was to estimate in this region the vaccine effectiveness (VE) in protecting newborns against laboratory-confirmed pertussis infection. A matched case–control study was undertaken in the period between 1 March 2015 and 29 February 2016. Twenty-two cases and 66 controls (+/− 15 days of age difference) were included in the study. Cases were non-vaccinated infants < 3 months of age at disease onset testing positive for pertussis by real-time PCR. For every case three unvaccinated controls were selected. Odds ratios (OR) were calculated by multiple conditional logistic regression for association between maternal vaccination and infant pertussis. Other children in the household, as well as mother- and environmental covariates were taken into account. The VE was calculated as 1 − OR. Mothers of five cases (23%) and of 41 controls (62%) were vaccinated during pregnancy. The adjusted VE was 90.9% (95% confidence interval (CI): 56.6 to 98.1). The only covariate in the final model was breastfeeding (protective effect). Our study provides evidence in favour of pertussis vaccination programmes for pregnant women in order to prevent whooping cough in infants aged less than 3 months.

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/content/10.2807/1560-7917.ES.2017.22.22.30545
2017-06-01
2024-11-20
http://instance.metastore.ingenta.com/content/10.2807/1560-7917.ES.2017.22.22.30545
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References

  1. Cherry JD. Epidemic pertussis in 2012--the resurgence of a vaccine-preventable disease. N Engl J Med. 2012;367(9):785-7.  https://doi.org/10.1056/NEJMp1209051  PMID: 22894554 
  2. Centers for Disease Control and Prevention (CDC). Pertussis epidemic--Washington, 2012. MMWR Morb Mortal Wkly Rep. 2012;61(28):517-22. PMID: 22810264 
  3. Sizaire V, Garrido-Estepa M, Masa-Calles J, Martínez de Aragon MV. Increase of pertussis incidence in 2010 to 2012 after 12 years of low circulation in Spain. Euro Surveill. 2014;19(32):20875.  https://doi.org/10.2807/1560-7917.ES2014.19.32.20875  PMID: 25139074 
  4. Míguez Santiyán A, Ferrer Estrems R, Chover Lara JL, Alberola Enguídanos J, Nogueira Coito JM, Salazar Cifre A. Early intervention in pertussis outbreak with high attack rate in cohort of adolescents with complete acellular pertussis vaccination in Valencia, Spain, April to May 2015. Euro Surveill. 2015;20(27):21183.  https://doi.org/10.2807/1560-7917.ES2015.20.27.21183  PMID: 26212062 
  5. Centers for Disease Control and Prevention (CDC). Updated recommendations for use of tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis vaccine (Tdap) in pregnant women--Advisory Committee on Immunization Practices (ACIP), 2012. MMWR Morb Mortal Wkly Rep. 2013;62(7):131-5. PMID: 23425962 
  6. Centers for Disease Control Prevention (CDC). Pertussis (whooping cough), surveillance and reporting 2014. Atlanta: CDC. [Accessed 5 Jun 2016]. Available at: http://www.cdc.gov/pertussis/ surv-reporting.html
  7. Wiley KE, Zuo Y, Macartney KK, McIntyre PB. Sources of pertussis infection in young infants: a review of key evidence informing targeting of the cocoon strategy. Vaccine. 2013;31(4):618-25.  https://doi.org/10.1016/j.vaccine.2012.11.052  PMID: 23200883 
  8. Lévy-Bruhl D. Protecting the very young against pertussis--cough, costs and cocooning. Euro Surveill. 2014;19(5):20689.  https://doi.org/10.2807/1560-7917.ES2014.19.5.20689  PMID: 24524233 
  9. Dabrera G, Amirthalingam G, Andrews N, Campbell H, Ribeiro S, Kara E, et al. A case-control study to estimate the effectiveness of maternal pertussis vaccination in protecting newborn infants in England and Wales, 2012-2013. Clin Infect Dis. 2015;60(3):333-7.  https://doi.org/10.1093/cid/ciu821  PMID: 25332078 
  10. Amirthalingam G, Andrews N, Campbell H, Ribeiro S, Kara E, Donegan K, et al. Effectiveness of maternal pertussis vaccination in England: an observational study. Lancet. 2014;384(9953):1521-8.  https://doi.org/10.1016/S0140-6736(14)60686-3  PMID: 25037990 
  11. Abu Raya B, Srugo I, Kessel A, Peterman M, Bader D, Peri R, et al. The induction of breast milk pertussis specific antibodies following gestational tetanus-diphtheria-acellular pertussis vaccination. Vaccine. 2014;32(43):5632-7.  https://doi.org/10.1016/j.vaccine.2014.08.006  PMID: 25148774 
  12. Donaldson B, Jain P, Holder BS, Lindsay B, Regan L, Kampmann B. What determines uptake of pertussis vaccine in pregnancy? A cross sectional survey in an ethnically diverse population of pregnant women in London. Vaccine. 2015;33(43):5822-8.  https://doi.org/10.1016/j.vaccine.2015.08.093  PMID: 26409139 
  13. Quinn HE, Snelling TL, Habig A, Chiu C, Spokes PJ, McIntyre PB. Parental Tdap boosters and infant pertussis: a case-control study. Pediatrics. 2014;134(4):713-20.  https://doi.org/10.1542/peds.2014-1105  PMID: 25225136 
  14. Vilajeliu A, Goncé A, López M, Costa J, Rocamora L, Ríos J, et al. PERTU Working Group. Combined tetanus-diphtheria and pertussis vaccine during pregnancy: transfer of maternal pertussis antibodies to the newborn. Vaccine. 2015;33(8):1056-62.  https://doi.org/10.1016/j.vaccine.2014.12.062  PMID: 25573035 
  15. Han WG, Hodemaekers HM, Nagarajah B, Poelen MM, Helm K, Janssen R, et al. Association of vitamin D receptor polymorphism with susceptibility to symptomatic pertussis. PLoS One. 2016;11(2):e0149576.  https://doi.org/10.1371/journal.pone.0149576  PMID: 26894582 
  16. Ladhani SN, Andrews NJ, Southern J, Jones CE, Amirthalingam G, Waight PA, et al. Antibody responses after primary immunization in infants born to women receiving a pertussis-containing vaccine during pregnancy: single arm observational study with a historical comparator. Clin Infect Dis. 2015;61(11):1637-44.  https://doi.org/10.1093/cid/civ695  PMID: 26374816 
  17. Clark TA. Changing pertussis epidemiology: everything old is new again. J Infect Dis. 2014;209(7):978-81.  https://doi.org/10.1093/infdis/jiu001  PMID: 24626532 
  18. Winter K, Nickell S, Powell M, Harriman K. Effectiveness of Prenatal Versus Postpartum Tetanus, Diphtheria, and Acellular Pertussis Vaccination in Preventing Infant Pertussis. Clin Infect Dis. 2017;64(1):3-8.  https://doi.org/10.1093/cid/ciw634  PMID: 27624955 
  19. Winter K, Cherry JD, Harriman K. Effectiveness of Prenatal Tetanus, Diphtheria, and Acellular Pertussis Vaccination on Pertussis Severity in Infants. Clin Infect Dis. 2017;64(1):9-14.  https://doi.org/10.1093/cid/ciw633  PMID: 27624956 
  20. Baxter R, Bartlett J, Fireman B, Lewis E, Klein NP. Effectiveness of Vaccination During Pregnancy to Prevent Infant Pertussis. Pediatrics. 2017;139(5):e20164091.  https://doi.org/10.1542/peds.2016-4091 
A case–control study to assess the effectiveness of pertussis vaccination during pregnancy on newborns, Valencian community, Spain, 1 March 2015 to 29 February 2016
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=Juan+Bellido-Blasco&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Bellido-Blasco Juan</a>, <a href="/search?value1=Silvia+Guiral-Rodrigo&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Guiral-Rodrigo Silvia</a>, <a href="/search?value1=Ana++M%C3%ADguez-Santiy%C3%A1n&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Míguez-Santiyán Ana </a>, <a href="/search?value1=Antonio+Salazar-Cifre&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Salazar-Cifre Antonio</a>, <a href="/search?value1=Francisco+Gonz%C3%A1lez-Mor%C3%A1n&option1=author&noRedirect=true" class="nonDisambigAuthorLink">González-Morán Francisco</a></span>. A case–control study to assess the effectiveness of pertussis vaccination during pregnancy on newborns, Valencian community, Spain, 1 March 2015 to 29 February 2016. <a href="/content/ecdc">Euro Surveill.</a> 2017;22(22):pii=30545. <a href="https://doi.org/10.2807/1560-7917.ES.2017.22.22.30545" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2017.22.22.30545</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 10 Apr 2017;&nbsp;&nbsp; <span class="generated">Accepted</span>: 25 Apr 2017 </span> </p>
/content/10.2807/1560-7917.ES.2017.22.22.30545
/content/10.2807/1560-7917.ES.2017.22.22.30545
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