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Abstract

Recently, the plasmid-mediated colistin resistance gene was found in from humans, pigs and retail meat in China. Several reports have documented global presence of the gene in from humans, food animals and food since. We screened several well-characterised strain collections of , obtained from retail chicken meat and hospitalised patients in the Netherlands between 2009 and 2015, for presence of colistin resistance and the gene. A total of 2,471 isolates, from surveys in retail chicken meat (196 isolates), prevalence surveys in hospitalised patients (1,247 isolates), clinical cultures (813 isolates) and outbreaks in healthcare settings (215 isolates), were analysed. The gene was identified in three (1.5%) of 196 extended-spectrum beta-lactamase (ESBL)-producing isolates from retail chicken meat samples in 2009 and 2014. Two isolates were obtained from the same batch of meat samples, most likely representing contamination from a common source. No -positive isolates were identified among 2,275 human isolates tested. All -1-positive isolates were colistin-resistant (minimum inhibitory concentration (MIC) > 2 mg/L). Our findings indicate that -1-based colistin-resistance currently poses no threat to healthcare in the Netherlands. They indicate however that continued monitoring of colistin resistance and its underlying mechanisms in humans, livestock and food is needed.

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/content/10.2807/1560-7917.ES.2016.21.9.30149
2016-03-03
2024-11-15
http://instance.metastore.ingenta.com/content/10.2807/1560-7917.ES.2016.21.9.30149
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Presence of mcr-1-positive Enterobacteriaceae in retail chicken meat but not in humans in the Netherlands since 2009
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=Marjolein+F+Kluytmans%E2%80%93van+den+Bergh&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Kluytmans–van den Bergh Marjolein F</a>, <a href="/search?value1=Pepijn+Huizinga&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Huizinga Pepijn</a>, <a href="/search?value1=Marc+J+Bonten&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Bonten Marc J</a>, <a href="/search?value1=Martine+Bos&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Bos Martine</a>, <a href="/search?value1=Katrien+De+Bruyne&option1=author&noRedirect=true" class="nonDisambigAuthorLink">De Bruyne Katrien</a>, <a href="/search?value1=Alexander+W+Friedrich&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Friedrich Alexander W</a>, <a href="/search?value1=John+W+Rossen&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Rossen John W</a>, <a href="/search?value1=Paul+H+Savelkoul&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Savelkoul Paul H</a>, <a href="/search?value1=Jan+A+Kluytmans&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Kluytmans Jan A</a></span>. Presence of mcr-1-positive Enterobacteriaceae in retail chicken meat but not in humans in the Netherlands since 2009. <a href="/content/ecdc">Euro Surveill.</a> 2016;21(9):pii=30149. <a href="https://doi.org/10.2807/1560-7917.ES.2016.21.9.30149" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2016.21.9.30149</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 23 Dec 2015;&nbsp;&nbsp; <span class="generated">Accepted</span>: 01 Feb 2016 </span> </p>
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