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Abstract

From January to April 2015, Réunion experienced a major outbreak of acute haemorrhagic conjunctivitis (AHC) caused by coxsackievirus A24, which heavily impacted the healthcare system. According to the general practitioners’ (GP) sentinel network, the number of medical consultations due to conjunctivitis during this period was estimated at ca 100,000. This report describes the characteristics of the outbreak, which were obtained through several different yet complementary surveillance systems on the island. These included the network of hospital emergency departments (OSCOUR network), the GPs’ sentinel network, an Internet-based population cohort (‘Koman i lé’) participating in a survey on distinct symptoms including ‘red eyes’ and the monitoring of eye drop sales. Overall the results of the different surveillance approaches were in good agreement regarding the outbreak dynamic. A peak of patients with conjunctivitis was detected in the first 15 days of March (week 10 and 11), coinciding with increased eye drop sales on the island. Strains recovered from outbreak cases belonged to genotype IV and were most closely related to strains identified in AHC outbreaks in China, Egypt and Japan since 2010. Continued surveillance of AHC in Réunion remains important not only locally, but also because frequent exchanges between the island and mainland France may lead to introduction of this virus in Europe.

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/content/10.2807/1560-7917.ES.2016.21.26.30271
2016-06-30
2024-11-07
http://instance.metastore.ingenta.com/content/10.2807/1560-7917.ES.2016.21.26.30271
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References

  1. Hierholzer JC, Hilliard KA, Esposito JJ. Serosurvey for "acute hemorrhagic conjunctivitis" virus (Enterovirus 70) antibodies in the Southeastern United States, with review of the literature and some epidemiologic implications. Am J Epidemiol. 1975;102(6):533-44. PMID: 1202955 
  2. Centers for Disease Control and Prevention (CDC). Notes from the field: acute hemorrhagic conjunctivitis outbreaks caused by coxsackievirus A24v --- Uganda and southern Sudan, 2010. MMWR Morb Mortal Wkly Rep. 2010;59(32):1024. PMID: 20724969 
  3. Lévêque N, Huguet P, Norder H, Chomel JJ. Les Enterovirus responsables de conjonctivite aiguë hémorragique. [Enteroviruses responsible for acute hemorrhagic conjunctivitis]. Med Mal Infect. 2010;40(4):212-8.  https://doi.org/10.1016/j.medmal.2009.09.006  PMID: 19836177 
  4. Mirkovic RR, Schmidt NJ, Yin-Murphy M, Melnick JL. Enterovirus etiology of the 1970 Singapore epidemic of acute conjunctivitis. Intervirology. 1974;4(2):119-27. PMID: 4217326 
  5. Heymann DL. Control of communicable diseases manual. 19th Edition. Washington, DC: American Public Health Association;2008. p.746.
  6. Lernout T, Maillard O, Boireaux S, Collet L, Filleul L. A large outbreak of conjunctivitis on Mayotte Island, France, February to May 2012. Euro Surveill. 2012;17(23):20192. PMID: 22720741 
  7. Josseran L, Fouillet A, Caillère N, Brun-Ney D, Ilef D, Brucker G, et al. Assessment of a syndromic surveillance system based on morbidity data: results from the Oscour network during a heat wave. PLoS One. 2010;5(8):e11984.  https://doi.org/10.1371/journal.pone.0011984  PMID: 20711252 
  8. Vilain P, Filleul L. La surveillance syndromique à la Réunion: un système de surveillance intégré. [Syndromic surveillance in Réunion: An integrated surveillance system]. Bulletin de veille sanitaire océan Indien. 2013;21:9-12. French. Available from: http://www.invs.sante.fr/fr/Publications-et-outils/Bulletin-de-veille-sanitaire/Tous-les-numeros/Ocean-indien-Reunion-Mayotte/Bulletin-de-veille-sanitaire-ocean-Indien.-N-21-Septembre-2013
  9. World Health Organization (WHO). International statistical classification of diseases and related health problems. 10th revision. Geneva, Switzerland: WHO. [Accessed 2 Jan 2015]. Available from: http://apps.who.int/classifications/icd10/browse/2016/en
  10. Brottet E, Jaffar-Bandjee MC, Rachou E, Polycarpe D, Ristor B, Larrieu S, et al. Sentinel physician’s network in Reunion Island: a tool for infectious diseases surveillance. Med Mal Infect. 2015;45(1-2):21-8.  https://doi.org/10.1016/j.medmal.2014.11.004  PMID: 25575412 
  11. Brottet E, Vandroux D, Gauzere BA, Antok E, Jaffar-Bandjee MC, Michault A, et al. Influenza season in Réunion dominated by influenza B virus circulation associated with numerous cases of severe disease, France, 2014. Euro Surveill. 2014;19(39):20916.  https://doi.org/10.2807/1560-7917.ES2014.19.39.20916  PMID: 25306979 
  12. Vilain P, Caillere N, Larrieu S, Ristor B, Filleul L. Utilisation des données de l’assurance maladie pour la surveillance syndromique à la Réunion. [Using data from health insurance for syndromic surveillance in Réunion]. Bulletin de veille sanitaire océan Indien. 2012;17:10-14.French.
  13. « Koman i lé »: une population sentinelle à la Réunion. Présentation du système de surveillance et premiers résultats, avril 2014, La Réunion. [« Koman i lé »: a sentinel population network in Réunion. Introduction to the surveillance system and first results]. Bulletin de veille sanitaire océan Indien. 2014;24:2-5. French. Available from: http://www.invs.sante.fr/fr/Publications-et-outils/Bulletin-de-veille-sanitaire/Tous-les-numeros/Ocean-indien-Reunion-Mayotte/Bulletin-de-veille-sanitaire-ocean-Indien.-N-24-Octobre-2014.
  14. Nix WA, Oberste MS, Pallansch MA. Sensitive, seminested PCR amplification of VP1 sequences for direct identification of all enterovirus serotypes from original clinical specimens. J Clin Microbiol. 2006;44(8):2698-704.  https://doi.org/10.1128/JCM.00542-06  PMID: 16891480 
  15. Altschul SF, Gish W, Miller W, Myers EW, Lipman DJ. Basic local alignment search tool. J Mol Biol. 1990;215(3):403-10.  https://doi.org/10.1016/S0022-2836(05)80360-2  PMID: 2231712 
  16. Hall RJ, Wang J, Todd AK, Bissielo AB, Yen S, Strydom H, et al. Evaluation of rapid and simple techniques for the enrichment of viruses prior to metagenomic virus discovery. J Virol Methods. 2014;195:194-204.  https://doi.org/10.1016/j.jviromet.2013.08.035  PMID: 24036074 
  17. de Vries M, Deijs M, Canuti M, van Schaik BD, Faria NR, van de Garde MD, et al. A sensitive assay for virus discovery in respiratory clinical samples. PLoS One. 2011;6(1):e16118.  https://doi.org/10.1371/journal.pone.0016118  PMID: 21283679 
  18. Chevreux B, Wetter T, Suhai S. Genome sequence assembly using trace signals and additional sequence information. In: Proceedings of the German Conference on Bioinformatics: Computer Science and Biology; 1999; Hannover, Germany: p.45-56.
  19. Charlebois P, Yang X, Newman R, Henn M, Zody M. V-FAT: a post-assembly pipeline for the finishing and annotation of viral genomes; 2012. Available from: http://www. broadinstitute.org/scientific-community/science/projects/viral-genomics/v-fat
  20. Lole KS, Bollinger RC, Paranjape RS, Gadkari D, Kulkarni SS, Novak NG, et al. Full-length human immunodeficiency virus type 1 genomes from subtype C-infected seroconverters in India, with evidence of intersubtype recombination. J Virol. 1999;73(1):152-60. PMID: 9847317 
  21. Ayoub EA, Shafik CF, Gaynor AM, Mohareb EW, Amin MA, Yassin AS, et al. A molecular investigative approach to an outbreak of acute hemorrhagic conjunctivitis in Egypt, October 2010. Virol J. 2013;10(1):96.  https://doi.org/10.1186/1743-422X-10-96  PMID: 23531270 
  22. Nidaira M, Kuba Y, Saitoh M, Taira K, Maeshiro N, Mahoe Y, et al. Molecular evolution of VP3, VP1, 3C(pro) and 3D(pol) coding regions in coxsackievirus group A type 24 variant isolates from acute hemorrhagic conjunctivitis in 2011 in Okinawa, Japan. Microbiol Immunol. 2014;58(4):227-38.  https://doi.org/10.1111/1348-0421.12141  PMID: 24517637 
  23. Yan D, Zhu S, Zhang Y, Zhang J, Zhou Y, Xu W. Outbreak of acute hemorrhagic conjunctivitis in Yunnan, People’s Republic of China, 2007. Virol J. 2010;7(1):138.  https://doi.org/10.1186/1743-422X-7-138  PMID: 20579343 
  24. Wu B, Qi X, Xu K, Ji H, Zhu Y, Tang F, et al. Genetic characteristics of the coxsackievirus A24 variant causing outbreaks of acute hemorrhagic conjunctivitis in Jiangsu, China, 2010. PLoS One. 2014;9(1):e86883.  https://doi.org/10.1371/journal.pone.0086883  PMID: 24475191 
  25. De W, Huanying Z, Hui L, Corina M, Xue G, Leng L, et al. Phylogenetic and molecular characterization of coxsackievirus A24 variant isolates from a 2010 acute hemorrhagic conjunctivitis outbreak in Guangdong, China. Virol J. 2012;9(1):41.  https://doi.org/10.1186/1743-422X-9-41  PMID: 22336176 
  26. Tavares FN, Campos RM, Burlandy FM, Fontella R, de Melo MM, da Costa EV, et al. Molecular characterization and phylogenetic study of coxsackievirus A24v causing outbreaks of acute hemorrhagic conjunctivitis (AHC) in Brazil. PLoS One. 2011;6(8):e23206.  https://doi.org/10.1371/journal.pone.0023206  PMID: 21858030 
  27. Ong AE, Dashraath P, Lee VJ. Management of enteroviral conjunctivitis outbreaks in the Singapore military in 2005. Southeast Asian J Trop Med Public Health. 2008;39(3):398-403. PMID: 18564678 
  28. Aubry C, Gautret P, Nougairede A, Dussouil AS, Botelho-Nevers E, Zandotti C, et al. 2012 outbreak of acute haemorrhagic conjunctivitis in Indian Ocean Islands: identification of Coxsackievirus A24 in a returned traveller. Euro Surveill. 2012;17(22):20185.
  29. Institut de Veille Sanitaire. Point épidémiologique. Epidémie saisonnière de conjonctivite à la Réunion. [Seasonal epidemic of conjunctivitis in Réunion]. Point épidémiologique n°18. Cire Océan Indien;12 Mar 2015. French. Available from: http://www.invs.sante.fr/fr/Publications-et-outils/Points-epidemiologiques/Tous-les-numeros/Ocean-Indien/2015/Surveillance-de-la-conjonctivite-a-La-Reunion.-Point-epidemiologique-au-5-mars-2015
A major outbreak of conjunctivitis caused by coxsackievirus A24, Réunion, January to April 2015
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=Nad%C3%A8ge+Marguerite&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Marguerite Nadège</a>, <a href="/search?value1=Elise+Brottet&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Brottet Elise</a>, <a href="/search?value1=Fr%C3%A9d%C3%A9ric+Pag%C3%A8s&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Pagès Frédéric</a>, <a href="/search?value1=Marie+Christine+Jaffar-Bandjee&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Jaffar-Bandjee Marie Christine</a>, <a href="/search?value1=Isabelle+Schuffenecker&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Schuffenecker Isabelle</a>, <a href="/search?value1=Laurence+Josset&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Josset Laurence</a>, <a href="/search?value1=Pascal+Vilain&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Vilain Pascal</a>, <a href="/search?value1=Laurent+Filleul&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Filleul Laurent</a></span>. A major outbreak of conjunctivitis caused by coxsackievirus A24, Réunion, January to April 2015. <a href="/content/ecdc">Euro Surveill.</a> 2016;21(26):pii=30271. <a href="https://doi.org/10.2807/1560-7917.ES.2016.21.26.30271" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2016.21.26.30271</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 10 Jul 2015;&nbsp;&nbsp; <span class="generated">Accepted</span>: 17 Apr 2016 </span> </p>
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