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Abstract

Using a test-negative design, the Canadian Sentinel Practitioner Surveillance Network (SPSN) assessed interim 2015/16 vaccine effectiveness (VE) against influenza A(H1N1)pdm09 viruses. Adjusted VE showed significant protection of 64% (95% confidence interval (CI): 44–77%) overall and 56% (95%CI: 26–73%) for adults between 20 and 64 years-old against medically attended, laboratory-confirmed A(H1N1)pdm09 illness. Among the 67 A(H1N1)pdm09-positive specimens that were successfully sequenced, 62 (> 90%) belonged to the emerging genetic 6B.1 subclade, defined by S162N (potential gain of glycosylation) and I216T mutations in the haemagglutinin protein. Findings from the Canadian SPSN indicate that the 2015/16 northern hemisphere vaccine provided significant protection against A(H1N1)pdm09 illness despite genetic evolution in circulating viruses.

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/content/10.2807/1560-7917.ES.2016.21.11.30168
2016-03-17
2024-11-13
http://instance.metastore.ingenta.com/content/10.2807/1560-7917.ES.2016.21.11.30168
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Interim estimates of 2015/16 vaccine effectiveness against influenza A(H1N1)pdm09, Canada, February 2016
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=Catharine+Chambers&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Chambers Catharine</a>, <a href="/search?value1=Danuta+M+Skowronski&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Skowronski Danuta M</a>, <a href="/search?value1=Suzana+Sabaiduc&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Sabaiduc Suzana</a>, <a href="/search?value1=Anne+Luise+Winter&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Winter Anne Luise</a>, <a href="/search?value1=James+A+Dickinson&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Dickinson James A</a>, <a href="/search?value1=Gaston+De+Serres&option1=author&noRedirect=true" class="nonDisambigAuthorLink">De Serres Gaston</a>, <a href="/search?value1=Jonathan+B+Gubbay&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Gubbay Jonathan B</a>, <a href="/search?value1=Steven+J+Drews&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Drews Steven J</a>, <a href="/search?value1=Christine+Martineau&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Martineau Christine</a>, <a href="/search?value1=Alireza+Eshaghi&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Eshaghi Alireza</a>, <a href="/search?value1=Mel+Krajden&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Krajden Mel</a>, <a href="/search?value1=Nathalie+Bastien&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Bastien Nathalie</a>, <a href="/search?value1=Yan+Li&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Li Yan</a></span>. Interim estimates of 2015/16 vaccine effectiveness against influenza A(H1N1)pdm09, Canada, February 2016. <a href="/content/ecdc">Euro Surveill.</a> 2016;21(11):pii=30168. <a href="https://doi.org/10.2807/1560-7917.ES.2016.21.11.30168" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2016.21.11.30168</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 25 Feb 2016;&nbsp;&nbsp; <span class="generated">Accepted</span>: 17 Mar 2016 </span> </p>
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