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Abstract

Real-world estimates of seasonal influenza vaccine effectiveness (VE) are important for early detection of vaccine failure. We developed a method for evaluating real-time in-season vaccine effectiveness (IVE) and overall seasonal VE. In a retrospective, register-based, cohort study including all two million individuals in Stockholm County, Sweden, during the influenza seasons from 2011/12 to 2014/15, vaccination status was obtained from Stockholm’s vaccine register. Main outcomes were hospitalisation or primary care visits for influenza (International Classification of Disease (ICD)-10 codes J09-J11). VE was assessed using Cox multivariate stratified and non-stratified analyses adjusting for age, sex, socioeconomic status, comorbidities and previous influenza vaccinations. Stratified analyses showed moderate VE in prevention of influenza hospitalisations among chronically ill adults ≥ 65 years in two of four seasons, and lower but still significant VE in one season; 53% (95% confidence interval (CI): 33–67) in 2012/13, 55% (95% CI: 25–73) in 2013/14 and 18% (95% CI: 3–31) in 2014/15. In conclusion, seasonal influenza vaccination was associated with substantial reductions in influenza-specific hospitalisation, particularly in adults ≥ 65 years with underlying chronic conditions. With the use of population-based patient register data on influenza-specific outcomes it will be possible to obtain real-time estimates of seasonal influenza VE.

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2016-10-27
2024-12-21
/content/10.2807/1560-7917.ES.2016.21.43.30381
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Real-time real-world analysis of seasonal influenza vaccine effectiveness: method development and assessment of a population-based cohort in Stockholm County, Sweden, seasons 2011/12 to 2014/15
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=Amy+Leval&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Leval Amy</a>, <a href="/search?value1=Maria+Pia+Hergens&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Hergens Maria Pia</a>, <a href="/search?value1=Karin+Persson&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Persson Karin</a>, <a href="/search?value1=%C3%85ke+%C3%96rtqvist&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Örtqvist Åke</a></span>. Real-time real-world analysis of seasonal influenza vaccine effectiveness: method development and assessment of a population-based cohort in Stockholm County, Sweden, seasons 2011/12 to 2014/15. <a href="/content/ecdc">Euro Surveill.</a> 2016;21(43):pii=30381. <a href="https://doi.org/10.2807/1560-7917.ES.2016.21.43.30381" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2016.21.43.30381</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 20 May 2016;&nbsp;&nbsp; <span class="generated">Accepted</span>: 12 Sept 2016 </span> </p>
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