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Abstract

As elsewhere, few (< 15%) sentinel influenza A(H3N2) clade 3C.2a viruses that dominated in Canada during the 2014/15 season could be antigenically characterised by haemagglutination inhibition (HI) assay. Clade 3C.2a viruses that could be HI-characterised had acquired genetic mutations during in vitro cell culture isolation that modified the potential glycosylation motif found in original patient specimens and the consensus sequence of circulating viruses at amino acid positions 158–160 of the haemagglutinin protein. Caution is warranted in extrapolating antigenic relatedness based on limited HI findings for clade 3C.2a viruses that continue to circulate globally.

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/content/10.2807/1560-7917.ES.2016.21.3.30112
2016-01-21
2024-11-23
http://instance.metastore.ingenta.com/content/10.2807/1560-7917.ES.2016.21.3.30112
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Mutations acquired during cell culture isolation may affect antigenic characterisation of influenza A(H3N2) clade 3C.2a viruses
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=Danuta+M+Skowronski&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Skowronski Danuta M</a>, <a href="/search?value1=Suzana+Sabaiduc&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Sabaiduc Suzana</a>, <a href="/search?value1=Catharine+Chambers&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Chambers Catharine</a>, <a href="/search?value1=Alireza+Eshaghi&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Eshaghi Alireza</a>, <a href="/search?value1=Jonathan+B+Gubbay&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Gubbay Jonathan B</a>, <a href="/search?value1=Mel+Krajden&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Krajden Mel</a>, <a href="/search?value1=Steven+J+Drews&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Drews Steven J</a>, <a href="/search?value1=Christine+Martineau&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Martineau Christine</a>, <a href="/search?value1=Gaston+De+Serres&option1=author&noRedirect=true" class="nonDisambigAuthorLink">De Serres Gaston</a>, <a href="/search?value1=James+A+Dickinson&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Dickinson James A</a>, <a href="/search?value1=Anne-Luise+Winter&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Winter Anne-Luise</a>, <a href="/search?value1=Nathalie+Bastien&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Bastien Nathalie</a>, <a href="/search?value1=Yan+Li&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Li Yan</a></span>. Mutations acquired during cell culture isolation may affect antigenic characterisation of influenza A(H3N2) clade 3C.2a viruses. <a href="/content/ecdc">Euro Surveill.</a> 2016;21(3):pii=30112. <a href="https://doi.org/10.2807/1560-7917.ES.2016.21.3.30112" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2016.21.3.30112</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 10 Dec 2015;&nbsp;&nbsp; <span class="generated">Accepted</span>: 21 Jan 2016 </span> </p>
/content/10.2807/1560-7917.ES.2016.21.3.30112
/content/10.2807/1560-7917.ES.2016.21.3.30112
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