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Abstract

Using a test-negative design, we assessed interim vaccine effectiveness (VE) for the 2017/18 epidemic of co-circulating influenza A(H3N2) and B(Yamagata) viruses. Adjusted VE for influenza A(H3N2), driven by a predominant subgroup of clade 3C.2a viruses with T131K + R142K + R261Q substitutions, was low at 17% (95% confidence interval (CI): −14 to 40). Adjusted VE for influenza B was higher at 55% (95% CI: 38 to 68) despite prominent use of trivalent vaccine containing lineage-mismatched influenza B(Victoria) antigen, suggesting cross-lineage protection.

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Addendum for Euro Surveill. 2018;23(5)
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/content/10.2807/1560-7917.ES.2018.23.5.18-00035
2018-02-01
2025-02-21
/content/10.2807/1560-7917.ES.2018.23.5.18-00035
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Early season co-circulation of influenza A(H3N2) and B(Yamagata): interim estimates of 2017/18 vaccine effectiveness, Canada, January 2018
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=Danuta+M+Skowronski&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Skowronski Danuta M</a>, <a href="/search?value1=Catharine+Chambers&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Chambers Catharine</a>, <a href="/search?value1=Gaston+De+Serres&option1=author&noRedirect=true" class="nonDisambigAuthorLink">De Serres Gaston</a>, <a href="/search?value1=James+A+Dickinson&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Dickinson James A</a>, <a href="/search?value1=Anne-Luise+Winter&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Winter Anne-Luise</a>, <a href="/search?value1=Rebecca+Hickman&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Hickman Rebecca</a>, <a href="/search?value1=Tracy+Chan&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Chan Tracy</a>, <a href="/search?value1=Agatha+N+Jassem&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Jassem Agatha N</a>, <a href="/search?value1=Steven+J+Drews&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Drews Steven J</a>, <a href="/search?value1=Hugues+Charest&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Charest Hugues</a>, <a href="/search?value1=Jonathan+B+Gubbay&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Gubbay Jonathan B</a>, <a href="/search?value1=Nathalie+Bastien&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Bastien Nathalie</a>, <a href="/search?value1=Yan+Li&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Li Yan</a>, <a href="/search?value1=Mel+Krajden&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Krajden Mel</a></span>. Early season co-circulation of influenza A(H3N2) and B(Yamagata): interim estimates of 2017/18 vaccine effectiveness, Canada, January 2018. <a href="/content/ecdc">Euro Surveill.</a> 2018;23(5):pii=18-00035. <a href="https://doi.org/10.2807/1560-7917.ES.2018.23.5.18-00035" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2018.23.5.18-00035</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 22 Jan 2018;&nbsp;&nbsp; <span class="generated">Accepted</span>: 31 Jan 2018 </span> </p>
/content/10.2807/1560-7917.ES.2018.23.5.18-00035
/content/10.2807/1560-7917.ES.2018.23.5.18-00035
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