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Abstract

Introduction

The United Kingdom is in the fourth season of introducing a universal childhood influenza vaccine programme. The 2016/17 season saw early influenza A(H3N2) virus circulation with care home outbreaks and increased excess mortality particularly in those 65 years or older. Virus characterisation data indicated emergence of genetic clusters within the A(H3N2) 3C.2a group which the 2016/17 vaccine strain belonged to. The test-negative case–control (TNCC) design was used to estimate vaccine effectiveness (VE) against laboratory confirmed influenza in primary care. Adjusted end-of-season vaccine effectiveness (aVE) estimates were 39.8% (95% confidence interval (CI): 23.1 to 52.8) against all influenza and 40.6% (95% CI: 19.0 to 56.3) in 18–64-year-olds, but no significant aVE in ≥ 65-year-olds. aVE was 65.8% (95% CI: 30.3 to 83.2) for 2–17-year-olds receiving quadrivalent live attenuated influenza vaccine. The findings continue to provide support for the ongoing roll-out of the paediatric vaccine programme, with a need for ongoing evaluation. The importance of effective interventions to protect the ≥ 65-year-olds remains.

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2017-11-02
2024-11-17
http://instance.metastore.ingenta.com/content/10.2807/1560-7917.ES.2017.22.44.17-00306
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End-of-season influenza vaccine effectiveness in adults and children, United Kingdom, 2016/17
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=Richard+Pebody&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Pebody Richard</a>, <a href="/search?value1=Fiona+Warburton&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Warburton Fiona</a>, <a href="/search?value1=Joanna+Ellis&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Ellis Joanna</a>, <a href="/search?value1=Nick+Andrews&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Andrews Nick</a>, <a href="/search?value1=Alison+Potts&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Potts Alison</a>, <a href="/search?value1=Simon+Cottrell&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Cottrell Simon</a>, <a href="/search?value1=Arlene+Reynolds&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Reynolds Arlene</a>, <a href="/search?value1=Rory+Gunson&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Gunson Rory</a>, <a href="/search?value1=Catherine+Thompson&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Thompson Catherine</a>, <a href="/search?value1=Monica+Galiano&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Galiano Monica</a>, <a href="/search?value1=Chris+Robertson&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Robertson Chris</a>, <a href="/search?value1=Naomh+Gallagher&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Gallagher Naomh</a>, <a href="/search?value1=Mary+Sinnathamby&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Sinnathamby Mary</a>, <a href="/search?value1=Ivelina+Yonova&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Yonova Ivelina</a>, <a href="/search?value1=Ana+Correa&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Correa Ana</a>, <a href="/search?value1=Catherine+Moore&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Moore Catherine</a>, <a href="/search?value1=Muhammad+Sartaj&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Sartaj Muhammad</a>, <a href="/search?value1=Simon+de+Lusignan&option1=author&noRedirect=true" class="nonDisambigAuthorLink">de Lusignan Simon</a>, <a href="/search?value1=Jim+McMenamin&option1=author&noRedirect=true" class="nonDisambigAuthorLink">McMenamin Jim</a>, <a href="/search?value1=Maria+Zambon&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Zambon Maria</a></span>. End-of-season influenza vaccine effectiveness in adults and children, United Kingdom, 2016/17. <a href="/content/ecdc">Euro Surveill.</a> 2017;22(44):pii=17-00306. <a href="https://doi.org/10.2807/1560-7917.ES.2017.22.44.17-00306" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2017.22.44.17-00306</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 04 May 2017;&nbsp;&nbsp; <span class="generated">Accepted</span>: 15 Aug 2017 </span> </p>
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