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Low 2016/17 season vaccine effectiveness against hospitalised influenza A(H3N2) among elderly: awareness warranted for 2017/18 season
- Marc Rondy1 , Alin Gherasim2,3 , Itziar Casado3,4 , Odile Launay5,6 , Caterina Rizzo7 , Daniela Pitigoi8 , Aukse Mickiene9 , Sierk D Marbus10 , Ausenda Machado11 , Ritva K Syrjänen12 , Iva Pem-Novose13 , Judith Krisztina Horváth14 , Amparo Larrauri2,3 , Jesús Castilla3,4 , Philippe Vanhems5,15,16 , Valeria Alfonsi7 , Alina E Ivanciuc17 , Monika Kuliese9 , Rianne van Gageldonk-Lafeber10 , Veronica Gomez11 , Niina Ikonen18 , Zvjezdana Lovric13 , Annamária Ferenczi14 , I-MOVE+ hospital working group19 , Alain Moren1
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View Affiliations Hide AffiliationsAffiliations: 1 EpiConcept, Paris, France 2 National Centre of Epidemiology, Institute of Health Carlos III, Madrid, Spain 3 CIBER Epidemiología y Salud Pública, Institute of Health Carlos III, Madrid, Spain 4 Instituto de Salud Pública de Navarra, IdiSNA, Pamplona, Spain 5 Inserm, F-CRIN, Innovative clinical research network in vaccinology (I-REIVAC), CIC 1417, Paris, France 6 Université Paris Descartes, Sorbonne Paris Cité, APHP, CIC Cochin-Pasteur, Paris, France 7 Istituto Superiore di Sanità, Rome, Italy 8 University of Medicine and Pharmacy Carol Davila, National Institute for Research Cantacuzino, Bucharest, Romania 9 Department of Infectious diseases of Lithuanian University of Health Sciences, Kaunas, Lithuania 10 Centre for Epidemiology and surveillance of infectious diseases, Centre for Infectious disease control, National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands 11 Epidemiology Research Unit, Epidemiology Department, National Health Institute Doutor Ricardo Jorge, Lisbon, Portugal 12 Impact Assessment Unit, National Institute for Health and Welfare, Tampere, Finland 13 Epidemiology Service, Croatian Institute of Public Health, Zagreb, Croatia 14 Office of the Chief Medical Officer, Budapest, Hungary 15 Infection Control and Epidemiology Unit, Hôpital Edouard Herriot, Hospices Civils de Lyon, Lyon, France 16 Emerging Pathogens Laboratory - Fondation Mérieux, Centre International de Recherche en Infectiologie, INSERM U1111, Centre National de la Recherche Scientifique (CNRS), UMR5308, Ecole Nationale Supérieure (ENS) de Lyon, Université Claude Bernard Lyon 1, Lyon, France; 17 National Institute for Research Cantacuzino, Bucharest, Romania, Faculty of Biology, Bucharest University 18 Unit of Expert Microbiology, National Institute for Health and Welfare, Helsinki, Finland 19 The members of the I-Move+ hospital working group are listed at the end of the articleMarc Rondym.rondy epiconcept.fr
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Citation style for this article: Rondy Marc, Gherasim Alin, Casado Itziar, Launay Odile, Rizzo Caterina, Pitigoi Daniela, Mickiene Aukse, Marbus Sierk D, Machado Ausenda, Syrjänen Ritva K, Pem-Novose Iva, Horváth Judith Krisztina, Larrauri Amparo, Castilla Jesús, Vanhems Philippe, Alfonsi Valeria, Ivanciuc Alina E, Kuliese Monika, van Gageldonk-Lafeber Rianne, Gomez Veronica, Ikonen Niina, Lovric Zvjezdana, Ferenczi Annamária, I-MOVE+ hospital working group, Moren Alain. Low 2016/17 season vaccine effectiveness against hospitalised influenza A(H3N2) among elderly: awareness warranted for 2017/18 season. Euro Surveill. 2017;22(41):pii=17-00645. https://doi.org/10.2807/1560-7917.ES.2017.22.41.17-00645 Received: 18 Sept 2017; Accepted: 12 Oct 2017
Abstract
In a multicentre European hospital study we measured influenza vaccine effectiveness (IVE) against A(H3N2) in 2016/17. Adjusted IVE was 17% (95% confidence interval (CI): 1 to 31) overall; 25% (95% CI: 2 to 43) among 65–79-year-olds and 13% (95% CI: −15 to 30) among those ≥ 80 years. As the A(H3N2) vaccine component has not changed for 2017/18, physicians and public health experts should be aware that IVE could be low where A(H3N2) viruses predominate.
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