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Abstract

A case of food-borne botulism occurred in Slovakia in 2015. type A was isolated from three nearly empty commercial hummus tubes. The product, which was sold in Slovakia and the Czech Republic, was withdrawn from the market and a warning was issued immediately through the European Commission’s Rapid Alert System for Food and Feed (RASFF). Further investigation revealed the presence of botulinum neurotoxin (BoNT) subtype BoNT/A3, a very rare subtype implicated in only one previous outbreak (Loch Maree in Scotland, 1922). It is the most divergent subtype of BoNT/A with 15.4% difference at the amino acid level compared with the prototype BoNT/A1. This makes it more prone to evading immunological and PCR-based detection. It is recommended that testing laboratories are advised that this subtype has been associated with food-borne botulism for the second time since the first outbreak almost 100 years ago, and to validate their immunological or PCR-based methods against this divergent subtype.

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2017-08-10
2024-11-21
http://instance.metastore.ingenta.com/content/10.2807/1560-7917.ES.2017.22.32.30591
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Reoccurrence of botulinum neurotoxin subtype A3 inducing food-borne botulism, Slovakia, 2015
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=Lucia+Mad%E2%80%99arov%C3%A1&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Mad’arová Lucia</a>, <a href="/search?value1=Brigitte+G+Dorner&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Dorner Brigitte G</a>, <a href="/search?value1=Lars+Schaade&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Schaade Lars</a>, <a href="/search?value1=Vladim%C3%ADr+Don%C3%A1th&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Donáth Vladimír</a>, <a href="/search?value1=M%C3%A1ria+Avdi%C4%8Dov%C3%A1&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Avdičová Mária</a>, <a href="/search?value1=Milota+Fatkulinov%C3%A1&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Fatkulinová Milota</a>, <a href="/search?value1=Jozef+Strh%C3%A1rsky&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Strhársky Jozef</a>, <a href="/search?value1=Ivana+Sedlia%C4%8Dikov%C3%A1&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Sedliačiková Ivana</a>, <a href="/search?value1=Cyril+Klement&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Klement Cyril</a>, <a href="/search?value1=Martin+B+Dorner&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Dorner Martin B</a></span>. Reoccurrence of botulinum neurotoxin subtype A3 inducing food-borne botulism, Slovakia, 2015. <a href="/content/ecdc">Euro Surveill.</a> 2017;22(32):pii=30591. <a href="https://doi.org/10.2807/1560-7917.ES.2017.22.32.30591" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2017.22.32.30591</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 10 Jun 2016;&nbsp;&nbsp; <span class="generated">Accepted</span>: 25 Nov 2016 </span> </p>
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