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Abstract

A novel colistin resistance gene was identified in a strain of , monophasic variant of serovar Typhimurium (4,5,12:i:- ), isolated from a pig at slaughter in Italy in 2013, and in strains collected during routine diagnostic of post-weaning diarrhoea in pigs from Spain and Belgium in 2015 and 2016. Immediate implementation of -screening including this novel gene variant is required for and from humans and food-producing animals in Europe.

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/content/10.2807/1560-7917.ES.2017.22.31.30589
2017-08-03
2024-11-22
http://instance.metastore.ingenta.com/content/10.2807/1560-7917.ES.2017.22.31.30589
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References

  1. Rhouma M, Beaudry F, Letellier A. Resistance to colistin: what is the fate for this antibiotic in pig production? Int J Antimicrob Agents. 2016;48(2):119-26.  https://doi.org/10.1016/j.ijantimicag.2016.04.008  PMID: 27234675 
  2. Pesciaroli M, Cucco L, De Luca S, Massacci FR, Maresca C, Medici L, et al. Association between pigs with high caecal Salmonella loads and carcass contamination. Int J Food Microbiol. 2017;242:82-6.  https://doi.org/10.1016/j.ijfoodmicro.2016.11.021  PMID: 27914322 
  3. European Committee on Antimicrobial Susceptibility Testing (EUCAST). Clinical Breakpoints. Växjö: EUCAST. Jun 2017. Available from: http://eucast.org/clinical_breakpoints
  4. Zankari E, Hasman H, Cosentino S, Vestergaard M, Rasmussen S, Lund O, et al. Identification of acquired antimicrobial resistance genes. J Antimicrob Chemother. 2012;67(11):2640-4.  https://doi.org/10.1093/jac/dks261  PMID: 22782487 
  5. Carattoli A, Zankari E, García-Fernández A, Voldby Larsen M, Lund O, Villa L, et al. In silico detection and typing of plasmids using PlasmidFinder and plasmid multilocus sequence typing. Antimicrob Agents Chemother. 2014;58(7):3895-903.  https://doi.org/10.1128/AAC.02412-14  PMID: 24777092 
  6. Liu YY, Wang Y, Walsh TR, Yi LX, Zhang R, Spencer J, et al. Emergence of plasmid-mediated colistin resistance mechanism MCR-1 in animals and human beings in China: a microbiological and molecular biological study. Lancet Infect Dis. 2016;16(2):161-8.  https://doi.org/10.1016/S1473-3099(15)00424-7  PMID: 26603172 
  7. Xavier BB, Lammens C, Ruhal R, Kumar-Singh S, Butaye P, Goossens H, et al. Identification of a novel plasmid-mediated colistin-resistance gene, mcr-2, in Escherichia coli, Belgium, June 2016. Euro Surveill. 2016;21(27):30280.  https://doi.org/10.2807/1560-7917.ES.2016.21.27.30280  PMID: 27416987 
  8. Poirel L, Jayol A, Nordmann P. Polymyxins: Antibacterial Activity, Susceptibility Testing, and Resistance Mechanisms Encoded by Plasmids or Chromosomes. Clin Microbiol Rev. 2017;30(2):557-96.  https://doi.org/10.1128/CMR.00064-16  PMID: 28275006 
  9. Yin W, Li H, Shen Y, Liu Z, Wang S, Shen Z, et al. Novel Plasmid-Mediated Colistin Resistance Gene mcr-3 in Escherichia coli. MBio. 2017;8(3):e00543-17.  https://doi.org/10.1128/mBio.00543-17  PMID: 28655818 
  10. Kearse M, Moir R, Wilson A, Stones-Havas S, Cheung M, Sturrock S, et al. Geneious Basic: an integrated and extendable desktop software platform for the organization and analysis of sequence data. Bioinformatics. 2012;28(12):1647-9.  https://doi.org/10.1093/bioinformatics/bts199  PMID: 22543367 
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