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Abstract

Given recent profound improvements in the effectiveness of antiviral treatment for chronic Hepatitis C virus (HCV) infection, we aimed to describe the characteristics of patients referred to hepatology expert centres in France from 2000 to 2007 and from 2010 to 2014, and to identify factors associated with severe liver disease at their first visit for evaluation. We analysed data from two sources covering all of France: the former hepatitis C surveillance network, which included patients between 2000 and 2007, and the ANRS CO22 HEPATHER multi-centre cohort, which included patients between 2012 and 2014. Severe liver disease (SLD) was defined as the presence of either cirrhosis (histological, biochemical or clinical) or hepatocellular carcinoma. Multivariable Poisson regression models were used to identify the factors associated with SLD in complete-case analysis and after multiple imputation. Overall, 16,851 patients were included in the analysis and SLD was diagnosed in 11.6%. SLD at first visit was significantly associated with known risk factors (male sex, history of excessive alcohol intake, HCV genotype 3), late referral to hepatologists after diagnosis and HCV diagnosis at an older age. Providing earlier specialised care and treatment may be an important target for public health action.

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/content/10.2807/1560-7917.ES.2017.22.30.30582
2017-07-27
2024-12-26
/content/10.2807/1560-7917.ES.2017.22.30.30582
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References

  1. Pillonel J, Laperche S. Trends in risk of transfusion-transmitted viral infections (HIV, HCV, HBV) in France between 1992 and 2003 and impact of nucleic acid testing (NAT). Euro Surveill. 2005;10(2):5-8. PMID: 15735313 
  2. Delarocque-Astagneau E, Meffre C, Dubois F, Pioche C, Le Strat Y, Roudot-Thoraval F, et al. The impact of the prevention programme of hepatitis C over more than a decade: the French experience. J Viral Hepat. 2010;17(6):435-43.  https://doi.org/10.1111/j.1365-2893.2009.01196.x  PMID: 19780936 
  3. Meffre C, Le Strat Y, Delarocque-Astagneau E, Dubois F, Antona D, Lemasson J-M, et al. Prevalence of hepatitis B and hepatitis C virus infections in France in 2004: social factors are important predictors after adjusting for known risk factors. J Med Virol. 2010;82(4):546-55.  https://doi.org/10.1002/jmv.21734  PMID: 20166185 
  4. Pioche C, Pelat C, Larsen C, Desenclos J-C, Jauffret-Roustide M. Estimation de la prévalence de l’hépatite C en population générale, France métropolitaine, 2011. [Estimation of hepatitis C prevalence in the general population, metropolitan France, 2011]. Bull Epidemiol Hebd (Paris). 2016; (13-14):224-9. French. Available from: http://invs.santepubliquefrance.fr/beh/2016/13-14/2016_13-14_1.html
  5. Brouard C, Le Strat Y, Larsen C, Jauffret-Roustide M, Lot F, Pillonel J. The undiagnosed chronically-infected HCV population in France. Implications for expanded testing recommendations in 2014. PLoS One. 2015;10(5):e0126920.  https://doi.org/10.1371/journal.pone.0126920  PMID: 25961575 
  6. Westbrook RH, Dusheiko G. Natural history of hepatitis C. J Hepatol. 2014;61(1) Suppl;S58-68.  https://doi.org/10.1016/j.jhep.2014.07.012  PMID: 25443346 
  7. Morgan TR, Ghany MG, Kim H-Y, Snow KK, Shiffman ML, De Santo JL, et al. HALT-C Trial Group. Outcome of sustained virological responders with histologically advanced chronic hepatitis C. Hepatology. 2010;52(3):833-44.  https://doi.org/10.1002/hep.23744  PMID: 20564351 
  8. George SL, Bacon BR, Brunt EM, Mihindukulasuriya KL, Hoffmann J, Di Bisceglie AM. Clinical, virologic, histologic, and biochemical outcomes after successful HCV therapy: a 5-year follow-up of 150 patients. Hepatology. 2009;49(3):729-38.  https://doi.org/10.1002/hep.22694  PMID: 19072828 
  9. Zopf S, Kremer AE, Neurath MF, Siebler J. Advances in hepatitis C therapy: What is the current state - what come’s next? World J Hepatol. 2016;8(3):139-47.  https://doi.org/10.4254/wjh.v8.i3.139  PMID: 26839638 
  10. European Association for the Study of the Liver. EASL Recommendations on Treatment of Hepatitis C 2016. J Hepatol. 2017;66(1):153-94.  https://doi.org/10.1016/j.jhep.2016.09.001  PMID: 27667367 
  11. Delarocque-Astagneau E, Roudot-Thoraval F, Campèse C, Desenclos J-C. Past excessive alcohol consumption: a major determinant of severe liver disease among newly referred hepatitis C virus infected patients in hepatology reference centers, France, 2001. Ann Epidemiol. 2005;15(8):551-7.  https://doi.org/10.1016/j.annepidem.2004.12.006  PMID: 16117999 
  12. Pol S, Bourliere M, Lucier S, Hezode C, Dorival C, Larrey D, et al. Safety and efficacy of daclatasvir-sofosbuvir in HCV genotype 1-mono-infected patients. J Hepatol. 2017;66(1):39-47.  https://doi.org/10.1016/j.jhep.2016.08.021  PMID: 27622858 
  13. European Association for Study of Liver, Asociacion Latinoamericana para el Estudio del Higado. EASL-ALEH Clinical Practice Guidelines: Non-invasive tests for evaluation of liver disease severity and prognosis. J Hepatol. 2015;63(1):237-64.  https://doi.org/10.1016/j.jhep.2015.04.006  PMID: 25911335 
  14. Gower E, Estes C, Blach S, Razavi-Shearer K, Razavi H. Global epidemiology and genotype distribution of the hepatitis C virus infection. J Hepatol. 2014;61(1) Suppl;S45-57.  https://doi.org/10.1016/j.jhep.2014.07.027  PMID: 25086286 
  15. Lavanchy D. Evolving epidemiology of hepatitis C virus. Clin Microbiol Infect. 2011;17(2):107-15.  https://doi.org/10.1111/j.1469-0691.2010.03432.x  PMID: 21091831 
  16. Royston P, Ambler G, Sauerbrei W. The use of fractional polynomials to model continuous risk variables in epidemiology. Int J Epidemiol. 1999;28(5):964-74.  https://doi.org/10.1093/ije/28.5.964  PMID: 10597998 
  17. Sterne JAC, White IR, Carlin JB, Spratt M, Royston P, Kenward MG, et al. Multiple imputation for missing data in epidemiological and clinical research: potential and pitfalls. BMJ. 2009;338(jun29 1):b2393. PMID: 19564179 
  18. Nevalainen J, Kenward MG, Virtanen SM. Missing values in longitudinal dietary data: a multiple imputation approach based on a fully conditional specification. Stat Med. 2009;28(29):3657-69.  https://doi.org/10.1002/sim.3731  PMID: 19757484 
  19. Barros AJD, Hirakata VN. Alternatives for logistic regression in cross-sectional studies: an empirical comparison of models that directly estimate the prevalence ratio. BMC Med Res Methodol. 2003;3(1):21.  https://doi.org/10.1186/1471-2288-3-21  PMID: 14567763 
  20. Morris TP, White IR, Carpenter JR, Stanworth SJ, Royston P. Combining fractional polynomial model building with multiple imputation. Stat Med. 2015;34(25):3298-317.  https://doi.org/10.1002/sim.6553  PMID: 26095614 
  21. Larsen C, Bousquet V, Delarocque-Astagneau E, Pioche C, Roudot-Thoraval F, Desenclos JC. Hepatitis C virus genotype 3 and the risk of severe liver disease in a large population of drug users in France. J Med Virol. 2010;82(10):1647-54.  https://doi.org/10.1002/jmv.21850  PMID: 20827760 
  22. Septfons A, Gautier A, Brouard C, Bernillon P, Nicolau J, Larsen C. Prévalence, morbidité et mortalité associées aux hépatites B et C chroniques dans la population hospitalisée en France, 2004-2011. [Prevalence, morbidity and mortality associated with chronic hepatitis B and C in the French hospitalized population (2004-2011)]. Bull Epidemiol Hebd (Paris). 2014;(12):202-9. French. Available from: http://invs.santepubliquefrance.fr//beh/2014/12/2014_12_1.html
  23. Leandro G, Mangia A, Hui J, Fabris P, Rubbia-Brandt L, Colloredo G, et al. Relationship between steatosis, inflammation, and fibrosis in chronic hepatitis C: a meta-analysis of individual patient data. Gastroenterology. 2006;130(6):1636-42.  https://doi.org/10.1053/j.gastro.2006.03.014  PMID: 16697727 
  24. Marabita F, Aghemo A, De Nicola S, Rumi MG, Cheroni C, Scavelli R, et al. Genetic variation in the interleukin-28B gene is not associated with fibrosis progression in patients with chronic hepatitis C and known date of infection. Hepatology. 2011;54(4):1127-34.  https://doi.org/10.1002/hep.24503  PMID: 21721028 
  25. Bochud P-Y, Cai T, Overbeck K, Bochud M, Dufour J-F, Müllhaupt B, et al. Genotype 3 is associated with accelerated fibrosis progression in chronic hepatitis C. J Hepatol. 2009;51(4):655-66.  https://doi.org/10.1016/j.jhep.2009.05.016  PMID: 19665246 
  26. Chen W, Tomlinson G, Krahn M, Heathcote J. Immigrant patients with chronic hepatitis C and advanced fibrosis have a higher risk of hepatocellular carcinoma. J Viral Hepat. 2012;19(8):574-80.  https://doi.org/10.1111/j.1365-2893.2012.01583.x  PMID: 22762142 
  27. Chen W, Krahn M. Disease burden of chronic hepatitis C among immigrants in Canada. J Viral Hepat. 2015;22(12):1043-54.  https://doi.org/10.1111/jvh.12432  PMID: 26110922 
  28. Sharma S, Carballo M, Feld JJ, Janssen HL. Immigration and viral hepatitis. J Hepatol. 2015;63(2):515-22.  https://doi.org/10.1016/j.jhep.2015.04.026  PMID: 25962882 
  29. Hatzakis A, Wait S, Bruix J, Buti M, Carballo M, Cavaleri M, et al. The state of hepatitis B and C in Europe: report from the hepatitis B and C summit conference. J Viral Hepat. 2011;18(Suppl 1):1-16.  https://doi.org/10.1111/j.1365-2893.2011.01499.x  PMID: 21824223 
  30. Poynard T, Bedossa P, Opolon P. Natural history of liver fibrosis progression in patients with chronic hepatitis C. Lancet. 1997;349(9055):825-32.  https://doi.org/10.1016/S0140-6736(96)07642-8  PMID: 9121257 
  31. Bottero J, Brouard C, Roudot-Thoraval F, Deuffic-Burban S, Hofliger P, Abergel A, et al. 2014 French guidelines for hepatitis B and C screening: a combined targeted and mass testing strategy of chronic viruses namely HBV, HCV and HIV. Liver Int. 2016;36(10):1442-9. PMID: 27043826 
  32. Haute Autorité de Santé. Prise en charge de l’hépatite C par les médicaments antiviraux d’action directe (AAD): Élargissement du périmètre de remboursement. [Treatment of HCV infection by direct-acting antivirals (DAAs): broadening of the eligibility criteria for of the public financing of costs]. 7 Dec 2016. French. Available from: http://www.has-sante.fr/portail/upload/docs/application/pdf/2016-12/recommandation_college_hepatite_c.pdf
  33. Haute Autorité de Santé. Avis de la Commission de Transparence: Antiviraux d’action directe. [Recommendations from the Transparency Committee: the direct-acting antivirals]. 8 Jun 2016. French. Available from: http://www.has-sante.fr/portail/upload/docs/application/pdf/2016-05/aad_avis_25052016_ct_25052016.pdf
  34. Poynard T, Imbert-Bismut F, Munteanu M, Messous D, Myers RP, Thabut D, et al. Overview of the diagnostic value of biochemical markers of liver fibrosis (FibroTest, HCV FibroSure) and necrosis (ActiTest) in patients with chronic hepatitis C. Comp Hepatol. 2004;3(1):8.  https://doi.org/10.1186/1476-5926-3-8  PMID: 15387887 
  35. Castéra L, Vergniol J, Foucher J, Le Bail B, Chanteloup E, Haaser M, et al. Prospective comparison of transient elastography, Fibrotest, APRI, and liver biopsy for the assessment of fibrosis in chronic hepatitis C. Gastroenterology. 2005;128(2):343-50.  https://doi.org/10.1053/j.gastro.2004.11.018  PMID: 15685546 
  36. Schuppan D, Afdhal NH. Liver cirrhosis. Lancet. 2008;371(9615):838-51.  https://doi.org/10.1016/S0140-6736(08)60383-9  PMID: 18328931 
Severe liver disease related to chronic hepatitis C virus infection in treatment-naive patients: epidemiological characteristics and associated factors at first expert centre visit, France, 2000 to 2007 and 2010 to 2014
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=Alice+Sanna&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Sanna Alice</a>, <a href="/search?value1=Yann+Le+Strat&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Le Strat Yann</a>, <a href="/search?value1=Fran%C3%A7oise+Roudot-Thoraval&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Roudot-Thoraval Françoise</a>, <a href="/search?value1=Sylvie++Deuffic+Burban&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Deuffic Burban Sylvie </a>, <a href="/search?value1=Patrizia+Carrieri&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Carrieri Patrizia</a>, <a href="/search?value1=Elisabeth+Delarocque-Astagneau&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Delarocque-Astagneau Elisabeth</a>, <a href="/search?value1=Christine+Larsen&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Larsen Christine</a></span>. Severe liver disease related to chronic hepatitis C virus infection in treatment-naive patients: epidemiological characteristics and associated factors at first expert centre visit, France, 2000 to 2007 and 2010 to 2014. <a href="/content/ecdc">Euro Surveill.</a> 2017;22(30):pii=30582. <a href="https://doi.org/10.2807/1560-7917.ES.2017.22.30.30582" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2017.22.30.30582</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 06 Dec 2016;&nbsp;&nbsp; <span class="generated">Accepted</span>: 14 May 2017 </span> </p>
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