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Abstract

We conducted a multicentre test-negative case–control study in 27 hospitals of 11 European countries to measure 2015/16 influenza vaccine effectiveness (IVE) against hospitalised influenza A(H1N1)pdm09 and B among people aged ≥ 65 years. Patients swabbed within 7 days after onset of symptoms compatible with severe acute respiratory infection were included. Information on demographics, vaccination and underlying conditions was collected. Using logistic regression, we measured IVE adjusted for potential confounders. We included 355 influenza A(H1N1)pdm09 cases, 110 influenza B cases, and 1,274 controls. Adjusted IVE against influenza A(H1N1)pdm09 was 42% (95% confidence interval (CI): 22 to 57). It was 59% (95% CI: 23 to 78), 48% (95% CI: 5 to 71), 43% (95% CI: 8 to 65) and 39% (95% CI: 7 to 60) in patients with diabetes mellitus, cancer, lung and heart disease, respectively. Adjusted IVE against influenza B was 52% (95% CI: 24 to 70). It was 62% (95% CI: 5 to 85), 60% (95% CI: 18 to 80) and 36% (95% CI: -23 to 67) in patients with diabetes mellitus, lung and heart disease, respectively. 2015/16 IVE estimates against hospitalised influenza in elderly people was moderate against influenza A(H1N1)pdm09 and B, including among those with diabetes mellitus, cancer, lung or heart diseases.

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/content/10.2807/1560-7917.ES.2017.22.30.30580
2017-07-27
2024-11-24
http://instance.metastore.ingenta.com/content/10.2807/1560-7917.ES.2017.22.30.30580
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2015/16 seasonal vaccine effectiveness against hospitalisation with influenza A(H1N1)pdm09 and B among elderly people in Europe: results from the I-MOVE+ project
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=Marc+Rondy&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Rondy Marc</a>, <a href="/search?value1=Amparo+Larrauri&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Larrauri Amparo</a>, <a href="/search?value1=Itziar+Casado&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Casado Itziar</a>, <a href="/search?value1=Valeria+Alfonsi&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Alfonsi Valeria</a>, <a href="/search?value1=Daniela+Pitigoi&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Pitigoi Daniela</a>, <a href="/search?value1=Odile+Launay&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Launay Odile</a>, <a href="/search?value1=Ritva+K+Syrj%C3%A4nen&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Syrjänen Ritva K</a>, <a href="/search?value1=Giedre+Gefenaite&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Gefenaite Giedre</a>, <a href="/search?value1=Ausenda+Machado&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Machado Ausenda</a>, <a href="/search?value1=Vesna+Vi%C5%A1ekruna+Vu%C4%8Dina&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Vučina Vesna Višekruna</a>, <a href="/search?value1=Judith+Krisztina+Horv%C3%A1th&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Horváth Judith Krisztina</a>, <a href="/search?value1=Iwona+Paradowska-Stankiewicz&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Paradowska-Stankiewicz Iwona</a>, <a href="/search?value1=Sierk+D+Marbus&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Marbus Sierk D</a>, <a href="/search?value1=Alin+Gherasim&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Gherasim Alin</a>, <a href="/search?value1=Jorge+Alberto+D%C3%ADaz-Gonz%C3%A1lez&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Díaz-González Jorge Alberto</a>, <a href="/search?value1=Caterina+Rizzo&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Rizzo Caterina</a>, <a href="/search?value1=Alina+E+Ivanciuc&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Ivanciuc Alina E</a>, <a href="/search?value1=Florence+Galtier&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Galtier Florence</a>, <a href="/search?value1=Niina+Ikonen&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Ikonen Niina</a>, <a href="/search?value1=Aukse+Mickiene&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Mickiene Aukse</a>, <a href="/search?value1=Veronica+Gomez&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Gomez Veronica</a>, <a href="/search?value1=Sanja++Kure%C4%8Di%C4%87+Filipovi%C4%87&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Kurečić Filipović Sanja </a>, <a href="/search?value1=Annam%C3%A1ria+Ferenczi&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Ferenczi Annamária</a>, <a href="/search?value1=Monika+R+Korcinska&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Korcinska Monika R</a>, <a href="/search?value1=Rianne+van+Gageldonk-Lafeber&option1=author&noRedirect=true" class="nonDisambigAuthorLink">van Gageldonk-Lafeber Rianne</a>, <a href="/search?value1=I-MOVE%2B+hospital+working+group&option1=author&noRedirect=true" class="nonDisambigAuthorLink">I-MOVE+ hospital working group</a>, <a href="/search?value1=Marta+Valenciano&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Valenciano Marta</a></span>. 2015/16 seasonal vaccine effectiveness against hospitalisation with influenza A(H1N1)pdm09 and B among elderly people in Europe: results from the I-MOVE+ project. <a href="/content/ecdc">Euro Surveill.</a> 2017;22(30):pii=30580. <a href="https://doi.org/10.2807/1560-7917.ES.2017.22.30.30580" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2017.22.30.30580</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 13 Oct 2016;&nbsp;&nbsp; <span class="generated">Accepted</span>: 08 Feb 2017 </span> </p>
/content/10.2807/1560-7917.ES.2017.22.30.30580
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