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Abstract

With no or low virulence in poultry, avian influenza A(H7N9) virus has caused severe infections in humans. In the current fifth epidemic wave, a highly pathogenic avian influenza (HPAI) H7N9 virus emerged. The insertion of four amino acids (KRTA) at the haemagglutinin (HA) cleavage site enabled trypsin-independent infectivity of this virus. Although maintaining dual receptor-binding preference, its HA antigenicity was distinct from low-pathogenic avian influenza A(H7N9). The neuraminidase substitution R292K conferred a multidrug resistance phenotype.

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/content/10.2807/1560-7917.ES.2017.22.19.30533
2017-05-11
2024-11-22
http://instance.metastore.ingenta.com/content/10.2807/1560-7917.ES.2017.22.19.30533
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Biological characterisation of the emerged highly pathogenic avian influenza (HPAI) A(H7N9) viruses in humans, in mainland China, 2016 to 2017
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=Wenfei+Zhu&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Zhu Wenfei</a>, <a href="/search?value1=Jianfang+Zhou&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Zhou Jianfang</a>, <a href="/search?value1=Zi+Li&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Li Zi</a>, <a href="/search?value1=Lei+Yang&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Yang Lei</a>, <a href="/search?value1=Xiyan+Li&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Li Xiyan</a>, <a href="/search?value1=Weijuan+Huang&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Huang Weijuan</a>, <a href="/search?value1=Sumei+Zou&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Zou Sumei</a>, <a href="/search?value1=Wenbing+Chen&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Chen Wenbing</a>, <a href="/search?value1=Hejiang+Wei&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Wei Hejiang</a>, <a href="/search?value1=Jing+Tang&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Tang Jing</a>, <a href="/search?value1=Liqi+Liu&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Liu Liqi</a>, <a href="/search?value1=Jie+Dong&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Dong Jie</a>, <a href="/search?value1=Dayan+Wang&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Wang Dayan</a>, <a href="/search?value1=Yuelong+Shu&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Shu Yuelong</a></span>. Biological characterisation of the emerged highly pathogenic avian influenza (HPAI) A(H7N9) viruses in humans, in mainland China, 2016 to 2017. <a href="/content/ecdc">Euro Surveill.</a> 2017;22(19):pii=30533. <a href="https://doi.org/10.2807/1560-7917.ES.2017.22.19.30533" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2017.22.19.30533</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 14 Apr 2017;&nbsp;&nbsp; <span class="generated">Accepted</span>: 10 May 2017 </span> </p>
/content/10.2807/1560-7917.ES.2017.22.19.30533
/content/10.2807/1560-7917.ES.2017.22.19.30533
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