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Abstract

We report the molecular investigations of a large influenza A(H3N2) outbreak, in a season characterised by sharp increase in influenza admissions since December 2016. Analysis of haemagglutinin (HA) sequences demonstrated co-circulation of multiple clades (3C.3a, 3C.2a and 3C.2a1). Most variants fell into a novel subclade (proposed as 3C.2a2); they possessed four unique amino acid substitutions in the HA protein and loss of a potential glycosylation site. These changes potentially modify the H3N2 strain antigenicity.

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/content/10.2807/1560-7917.ES.2017.22.8.30466
2017-02-23
2024-11-22
http://instance.metastore.ingenta.com/content/10.2807/1560-7917.ES.2017.22.8.30466
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Emergence of a novel subclade of influenza A(H3N2) virus in London, December 2016 to January 2017
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=Heli+Harvala&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Harvala Heli</a>, <a href="/search?value1=Dan+Frampton&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Frampton Dan</a>, <a href="/search?value1=Paul+Grant&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Grant Paul</a>, <a href="/search?value1=Jade+Raffle&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Raffle Jade</a>, <a href="/search?value1=Ruth+Bridget+Ferns&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Ferns Ruth Bridget</a>, <a href="/search?value1=Zisis+Kozlakidis&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Kozlakidis Zisis</a>, <a href="/search?value1=Paul+Kellam&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Kellam Paul</a>, <a href="/search?value1=Deenan+Pillay&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Pillay Deenan</a>, <a href="/search?value1=Andrew+Hayward&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Hayward Andrew</a>, <a href="/search?value1=Eleni+Nastouli&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Nastouli Eleni</a>, <a href="/search?value1=For+the+ICONIC+Consortium&option1=author&noRedirect=true" class="nonDisambigAuthorLink">For the ICONIC Consortium</a></span>. Emergence of a novel subclade of influenza A(H3N2) virus in London, December 2016 to January 2017. <a href="/content/ecdc">Euro Surveill.</a> 2017;22(8):pii=30466. <a href="https://doi.org/10.2807/1560-7917.ES.2017.22.8.30466" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2017.22.8.30466</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 13 Feb 2017;&nbsp;&nbsp; <span class="generated">Accepted</span>: 23 Feb 2017 </span> </p>
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