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Abstract

To enable an up-to-date molecular analysis of human immunodeficiency virus (HIV) genotypes circulating in Germany we have established a surveillance system based on recently acquired HIV infections. New HIV infections are reported to the Robert Koch Institute as a statutory duty for anonymous notification. In 2013 and 2014, a dried serum spot (DSS) sample was received from 6,371 newly diagnosed HIV-cases; their analysis suggested that 1,797 samples originated from a recent infection. Of these, 809 were successfully genotyped in the region to identify transmitted drug resistance (TDR) mutations and to determine the HIV-1 subtype. Total TDR was 10.8%, comprising 4.3% with mono-resistance to nucleoside reverse transcriptase inhibitors (NRTIs), 2.6% to non-NRTIs, 3.0% to protease inhibitors and 0.6% and 0.2%, respectively, with dual- and triple-class resistances. HIV-1 subtype B was most prevalent with 77.0%. Non-B infections were identified more often in men and women with heterosexual transmission compared with intravenous drug users or men who have sex with men (79% and 76%, 33%, 12%; all p < 0.05). Non-B subtypes were also more frequently found in patients originating from countries other than Germany (46% vs 14%; p < 0.05) and in patients infected outside of Germany (63% vs 14%; p < 0.05).

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/content/10.2807/1560-7917.ES.2017.22.2.30436
2017-01-12
2024-11-28
http://instance.metastore.ingenta.com/content/10.2807/1560-7917.ES.2017.22.2.30436
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National molecular surveillance of recently acquired HIV infections in Germany, 2013 to 2014
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=Andrea+Hauser&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Hauser Andrea</a>, <a href="/search?value1=Alexandra+Hofmann&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Hofmann Alexandra</a>, <a href="/search?value1=Kirsten+Hanke&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Hanke Kirsten</a>, <a href="/search?value1=Viviane+Bremer&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Bremer Viviane</a>, <a href="/search?value1=Barbara+Bartmeyer&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Bartmeyer Barbara</a>, <a href="/search?value1=Claudia+Kuecherer&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Kuecherer Claudia</a>, <a href="/search?value1=Norbert+Bannert&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Bannert Norbert</a></span>. National molecular surveillance of recently acquired HIV infections in Germany, 2013 to 2014. <a href="/content/ecdc">Euro Surveill.</a> 2017;22(2):pii=30436. <a href="https://doi.org/10.2807/1560-7917.ES.2017.22.2.30436" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2017.22.2.30436</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 01 Feb 2016;&nbsp;&nbsp; <span class="generated">Accepted</span>: 23 Aug 2016 </span> </p>
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