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Abstract

Although widely recommended, influenza vaccination of children is part of the national vaccination programme only in few countries. In addition to Canada and the United States (US), in Europe Finland and the United Kingdom have introduced live attenuated influenza vaccine (LAIV) for healthy children in their programmes. On 22 June 2016, the US Advisory Committee on Immunizations Practices, voted against further use of LAIV due to no observed vaccine effectiveness (VE) over three consecutive influenza seasons (2013/14 to 2015/16). We summarise the results of a nationwide, register-based cohort study (N=55,258 of whom 8,086 received LAIV and 4,297 TIV); all outcome (laboratory-confirmed influenza), exposure (vaccination) and confounding variable data were retrieved from four computerised national health registers, which were linked via a unique personal identity code assigned to all permanent Finnish residents regardless of nationality. Our study provides evidence of moderate effectiveness against any laboratory-confirmed influenza of the quadrivalent LAIV vaccine (VE: 51%; 95% confidence interval (CI): 28–66%) as well as the inactivated trivalent vaccine (VE: 61%; 95% CI: 31–78%) among two-year-olds during the influenza season 2015/16 in Finland. Based on these data, Finland will continue using LAIV for young children in its National Immunisation Programme this coming influenza season.

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/content/10.2807/1560-7917.ES.2016.21.38.30346
2016-09-22
2024-11-21
http://instance.metastore.ingenta.com/content/10.2807/1560-7917.ES.2016.21.38.30346
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References

  1. Mooring EQ, Bansal S. Increasing herd immunity with influenza revaccination. Epidemiol Infect. 2016;144(6):1267-77.  https://doi.org/10.1017/S0950268815002253  PMID: 26482721 
  2. Mereckiene J, Cotter S, Nicoll A, Lopalco P, Noori T, Weber J, et al. VENICE project gatekeepers group. Seasonal influenza immunisation in Europe. Overview of recommendations and vaccination coverage for three seasons: pre-pandemic (2008/09), pandemic (2009/10) and post-pandemic (2010/11). Euro Surveill. 2014;19(16):20780.  https://doi.org/10.2807/1560-7917.ES2014.19.16.20780  PMID: 24786262 
  3. Communicable disease act 25.7.1986/583. Available from: http://www.finlex.fi/fi/laki/ajantasa/1986/19860583
  4. Salo H, Kilpi T, Sintonen H, Linna M, Peltola V, Heikkinen T. Cost-effectiveness of influenza vaccination of healthy children. Vaccine. 2006;24(23):4934-41.  https://doi.org/10.1016/j.vaccine.2006.03.057  PMID: 16678945 
  5. Centers for Disease Control and Prevention (CDC). ACIP votes down use of LAIV for 2016-2017 flu season. Updated 22 Jun 2016. Atlanta: CDC; 2016. Available from: http://www.cdc.gov/media/releases/2016/s0622-laiv-flu.html
  6. Pebody R, Warburton F, Ellis J, Andrews N, Potts A, Cottrell S, et al. Effectiveness of seasonal influenza vaccine in preventing laboratory-confirmed influenza in primary care in the United Kingdom: 2015/16 mid-season results. Euro Surveill. 2016;21(13):30179.  https://doi.org/10.2807/1560-7917.ES.2016.21.13.30179  PMID: 27074651 
  7. Nohynek H, Baum U, Haveri A, Ikonen N, Jokinen J, Jääskeläinen S, et al. Seasonal childhood influenza vaccinations. Experiences from Finland. Nordic Vaccines Iceland, Apr 2016.
  8. National Institute for Health and Welfare. Finland. Vaccinations. 2016. [Accessed 26 May 2016]. Available from: https://www.thl.fi/fi/web/thlfi-en/statistics/information-on-statistics/quality-descriptions/vaccinations.
  9. Description of the Finnish National Medical Birth Register (NMBR). [Accessed on 19 Sep 2016]. Available from: https://www.thl.fi/fi/web/thlfi-en/statistics/information-on-statistics/register-descriptions/newborns
  10. Sund R. Quality of the Finnish Hospital Discharge Register: a systematic review. Scand J Public Health. 2012;40(6):505-15.  https://doi.org/10.1177/1403494812456637  PMID: 22899561 
  11. World Health Organization (WHO). International Statistical Classification of Diseases and Related Health Problems 10th Revision. 2016; Available from: http://apps.who.int/classifications/icd10/browse/2016/en
  12. Cox DR. Regression models life-tables. J R Stat Soc B. 1972;34(2):187-220.
  13. Rosenbaum PR, Rubin DB. The central role of the propensity score in observational studies for causal effect. Biometrika. 1983;70(1):41-55 . https://doi.org/10.1093/biomet/70.1.41 
  14. Andridge RR, Little RJ. A review of hot deck imputation for survey non-response. Int Stat Rev. 2010;78(1):40-64.  https://doi.org/10.1111/j.1751-5823.2010.00103.x  PMID: 21743766 
  15. Ikonen N, Murtopuro S, Haveri A, Virtanen MJ, Baum U, Nohynek H, et al. Influenssakausi Suomessa, viikot 40/2015–20/2016. THL publications 2016. URN:ISBN:978-952-302-682-7.
  16. Public Health England (PHE). Influenza vaccine effectiveness in adults and children in primary care in the UK: provisional end-of-season results 2015-16. [Accessed 27 Jun 2016]. Available from: https://www.gov.uk/government/uploads/system/uploads/attachment_data/file/530756/Influenza_vaccine_effectiveness_in_primary_care_in_children.pdf
  17. Pebody R, Warburton F, Ellis J, Andrews N, Potts A, Cottrell S, et al. Effectiveness of seasonal influenza vaccine for adults and children in preventing laboratory-confirmed influenza in primary care in the United Kingdom: 2015/16 end-of-season results. Euro Surveill. 2016;21(38):30348.  https://doi.org/10.2807/1560-7917.ES.2016.21.38.30348 
  18. Smith DJ, Forrest S, Ackley DH, Perelson AS. Variable efficacy of repeated annual influenza vaccination. Proc Natl Acad Sci USA. 1999;96(24):14001-6.  https://doi.org/10.1073/pnas.96.24.14001  PMID: 10570188 
  19. Block SL, Toback SL, Yi T, Ambrose CS. Efficacy of a single dose of live attenuated influenza vaccine in previously unvaccinated children: a post hoc analysis of three studies of children aged 2 to 6 years. Clin Ther. 2009;31(10):2140-7.  https://doi.org/10.1016/j.clinthera.2009.09.014  PMID: 19922885 
Effectiveness of the live attenuated and the inactivated influenza vaccine in two-year-olds – a nationwide cohort study Finland, influenza season 2015/16
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=Hanna+Nohynek&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Nohynek Hanna</a>, <a href="/search?value1=Ulrike+Baum&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Baum Ulrike</a>, <a href="/search?value1=Ritva+Syrj%C3%A4nen&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Syrjänen Ritva</a>, <a href="/search?value1=Niina+Ikonen&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Ikonen Niina</a>, <a href="/search?value1=Jonas+Sundman&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Sundman Jonas</a>, <a href="/search?value1=Jukka+Jokinen&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Jokinen Jukka</a></span>. Effectiveness of the live attenuated and the inactivated influenza vaccine in two-year-olds – a nationwide cohort study Finland, influenza season 2015/16. <a href="/content/ecdc">Euro Surveill.</a> 2016;21(38):pii=30346. <a href="https://doi.org/10.2807/1560-7917.ES.2016.21.38.30346" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2016.21.38.30346</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 19 Jul 2016;&nbsp;&nbsp; <span class="generated">Accepted</span>: 03 Sept 2016 </span> </p>
/content/10.2807/1560-7917.ES.2016.21.38.30346
/content/10.2807/1560-7917.ES.2016.21.38.30346
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