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Cluster of human parechovirus infections as the predominant cause of sepsis in neonates and infants, Leicester, United Kingdom, 8 May to 2 August 2016
- Julian W Tang1,2 , Christopher W Holmes1 , Fadwa A Elsanousi1 , Ayushi Patel1 , Fazila Adam1 , Rachel Speight3 , Savitha Shenoy3 , Daniel Bronnert3 , Gary Stiefel3 , Premkumar Sundaram3 , Suchandra Pande3 , Arani Sridhar3 , Venkatesh Kairamkonda3 , Srini Bandi3
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View Affiliations Hide AffiliationsAffiliations: 1 Clinical Microbiology and Virology, University Hospitals of Leicester NHS Trust, Leicester, United Kingdom 2 Infection, Immunity and Inflammation, University of Leicester, Leicester, United Kingdom 3 Leicester Childrens Hospital, University Hospitals of Leicester NHS Trust, Leicester, United KingdomJulian Tangjulian.tang uhl-tr.nhs.uk
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Citation style for this article: Tang Julian W, Holmes Christopher W, Elsanousi Fadwa A, Patel Ayushi, Adam Fazila, Speight Rachel, Shenoy Savitha, Bronnert Daniel, Stiefel Gary, Sundaram Premkumar, Pande Suchandra, Sridhar Arani, Kairamkonda Venkatesh, Bandi Srini. Cluster of human parechovirus infections as the predominant cause of sepsis in neonates and infants, Leicester, United Kingdom, 8 May to 2 August 2016. Euro Surveill. 2016;21(34):pii=30326. https://doi.org/10.2807/1560-7917.ES.2016.21.34.30326 Received: 11 Aug 2016; Accepted: 25 Aug 2016
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Abstract
We report an unusually high number of cases (n = 26) of parechovirus infections in the cerebrospinal fluid (CSF) of neonates and infants admitted with sepsis in the United Kingdom during 8 May to 2 August 2016. Although such infections in neonates and infants are well-documented, parechovirus has not been routinely included in many in-house and commercial PCR assays for CSF testing. Clinicians should consider routine parechovirus testing in young children presenting with sepsis.
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